NLS, nuclear localization signal
Functional exchangeability of the nuclear localization signal (NLS) of capsid protein between PCV1 and PCV2 in vitro: Implications for the role of NLS in viral replication
... the nuclear accumu- lation of PCV1 and PCV2 capsid protein are properly mediated by their distinct NLS motifs ...the NLS of PCV ORF2 would play an accessory role in viral replication due to its con- ...
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Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
... minor NLS-binding pocket of importin ...function, NLS score. NLS score is the sum of the normalized number of inter-atomic bonds, net hydrophobic/hydrophilic residues, and atomic contact energies ...
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Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF)
... the localization of the ...bipartite NLS was identified in every PH domain analyzed using cNLS mapper and many identified obtained a score about ...nucleus localization has not been identified ...
127
Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl
... The mutant protein (p.F157Lfs*5) results in a partial loss of kinase domain and a complete loss of the C-terminal domain compared to the wild type.. NLS, Nuclear localization signal, NRD[r] ...
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Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
... the nuclear envelope to associate with the genomic viral ...cells. Nuclear local- ization of the protein presupposes the presence of a nuclear localization signal (NLS) within ...
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The role of nuclear localization signal in parvovirus life cycle
... a signal plasmid, which may be because BR2, BR3, and BR4 are encoded by overlapping sequences of VP1 and VP2 ...VP localization to the ...for localization of VP2 into the nucleus and for virion ...a ...
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Possible Role for Cellular Karyopherins in Regulating Polyomavirus and Papillomavirus Capsid Assembly
... of nuclear import factors as possible “chaperones” in preventing the cytoplasmic assembly of papovavirus ...a nuclear localization signal (NLS)-dependent ...the NLS of VP1 and L1 ...
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Interactions and Nuclear Import of the N and P Proteins of Sonchus Yellow Net Virus, a Plant Nucleorhabdovirus
... The N and P proteins interact physically. Our previous studies (54) have revealed that N, P, and L interact with the genomic RNA to form a rapidly sedimenting nucleocapsid polymerase core complex. More slowly sedimenting ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... subcellular localization of viral proteins, especially in the nucleus, may contribute to cell apoptosis, viral replication or host cell proliferation [9, ...the nuclear localization signal ...
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Bräuer, Katharina Elisabeth Marianne (2018): Activity and substrate specificity of bacterial and human ribosomal oxygenases. Dissertation, LMU München: Fakultät für Biologie
... Wild type OGFOD1 exhibits the catalytically active N-terminal DSBH domain containing the iron coordinating HxD...H motif and a C-terminal DSBH lacking the iron-binding motif. N- terminal and C-terminal DSBH domains are ...
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A nuclear targeting system in Plasmodium falciparum
... bipartite signal sequence to facilitate apicoplast targeting and membrane translocation ...a nuclear targeting technique in ...a nuclear carrier ...A nuclear localiza- tion signal ...
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Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization
... facilitate localization studies and displays activity comparable to that of ...Tag), NLS, leucine zipper region (LZL), NES, activation domain (ACT), and GFP fusion ...
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Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis
... 2. Localization of different Apoptin ...GFP signal (a– c) or nuclear staining with DAPI (d–f) is ...GFP signal (a–f) and nuclear staining with DAPI (g–l) are ...or nuclear ...
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The ORF012 Gene of Marek's Disease Virus Type 1 Produces a Spliced Transcript and Encodes a Novel Nuclear Phosphoprotein Essential for Virus Growth
... an NLS that mapped to a 23-amino-acid stretch in the C-terminal region of ...control nuclear import was provided by our infection experiments using a set of mutant viruses carrying mutations in the ...
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Burstin, von, Vivian Annaluise (2011): PKC isozymes in the control of fate of prostate cancer cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Two experiments were performed, using the Affymetrix GeneChip ® Human Genome U133A 2.0 Array (Affymetrix Inc., Santa Clara CA, USA), which represents the expression level of 18,400 transcripts and variants, including ...
147
H IPSE is a pathogen secreted host nucleus infiltrating protein (infiltrin) expressed exclusively by the Schistosoma haematobium egg stage
... the NLS in H-IPSE is fully functional, and bearing in mind that the sequence cannot be functional within schistosome eggs themselves, as the N-terminal CSS will target the protein for secretion well before the ...
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Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx
... the same sequence [61]. A valid explanation for this selec- tive transactivation pattern, which apparently does not affect integrated sequences, would be its predominance in inactive chromatin compartments that have no ...
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Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)
... the nuclear translocation ability but has no effect on its nucleolar localization (Figure 2B and ...of nuclear/nu- cleolar translocation of different MSP58 family members are diverse and may vary in ...
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Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus
... of nuclear Int6 with ...no signal was obtained because of the absence of the other protein in the ...of nuclear Int6 to the cytoplasm by interaction with P56 using immunofluorescence as the detection ...
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Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
... IN NLS-mediated import is Ran-GTP-independent and, as is the case for the transit of some large proteins, ATP is required for transit through the nuclear pore complex ...the nuclear import of fusion ...
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