NOD-like receptor 3
Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways
... pathways, NOD-like receptor protein 3 (NLRP3) inflam- masome and nuclear factor kappa B (NF-κB) pathways play an important role [14, ...
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Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance
... FIG 3 Effects of Nlrc5 deletion in the lungs of IAV-infected mice. Mice were infected with 900 PFU of PR8 virus, and lungs were harvested on day 2 or 7 after infection. (A and B) Lung cytokine levels were ...
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Nod-Like Receptor X-1 Is Required for Rhinovirus-Induced Barrier Dysfunction in Airway Epithelial Cells
... drial ROS generation and that this requires the participation of NLRX-1. Interestingly, we found that, in both polarized 16HBE14o ⫺ cells and primary airway epithelial cells differenti- ated into a mucociliary phenotype, ...
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NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
... Total RNA extraction was conducted by RNeasy mini kit (Qiagen, Hilden, Germany), and cDNA was synthe- sized via Quantitect Reverse Transcription Kit (Qiagen) according to the manufacturer’s instructions. Target genes ...
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... in nod-like receptor (NLR) family are related to inflammasomes ...protein 3 (NLRP3) inflammasome is the most extensively studied inflammasome, consisting of NLRP3, adaptor protein apoptosis ...
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Molecular cloning of Peking duck Toll like receptor 3 (duTLR3) gene and its responses to reovirus infection
... The innate immune system is a major contributor to acute inflammation induced by microbial infection or tissue damage. The initial sensing of infection is mediated by in- nate pattern recognition receptors (PRRs), which ...
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Nod Like Receptor Pyrin Containing Protein 6 (NLRP6) Is Up regulated in Ileal Crohn’s Disease and Differentially Expressed in Goblet Cells
... cells. 3 By using immuno fl uorescence confocal microscopy we sort to ascer- tain the spatial relationship of NLRP6 to the major mucin protein MUC2 and the epithelial cell marker ...
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The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis
... chemokine receptor 5; CFA: complete Freud ’ s adjuvant; CFSE: carboxyfluorescein diacetate succinimidyl ester; CNS: central nervous system; COX2: cyclooxygenase 2; DCs: Dendritic cells; EAE: experimental ...
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NOD like receptors and inflammation
... proteinase 3, primes human monocytic cells, via protease-activated receptor-2, to produce cytokines ...proteinase 3 is downregulated in rheumatoid arthritis patients after treatment with the anti-TNF ...
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The emerging role of metabolic regulation in the functioning of Toll like receptors and the NOD like receptor Nlrp3
... to glycolysis, similar to that occurring in tumours [3]. The NLRP3 inflammasome on the other hand has been shown to cause insulin insensitivity and may be important for the pathogenesis of type 2 diabetes (T2D) ...
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MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease
... Toll- like receptors and NOD-like receptors (NLRs) ...the nod- like receptor protein (NLRP) family, adaptor protein ASC and proinflammatory precursor pro-caspase-1 ...P2X7 ...
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NOD2 and inflammation: current insights
... 16 like 1; ER, endoplasmic reticulum; ERK, extracellular signal-regulated kinase; IFNs, interferons; IKB, NF-κB inhibitor; IKK, IκB kinase; IRF3, interferon response factor 3; JNK, c-Jun N-terminal kinase; ...
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A sub-compatible rhizobium strain reveals infection duality in Lotus
... SYMbiotic Receptor-like Kinase SYMRK in trans- genic roots (as described in Ried et ...upon Nod factor production and supports a perception mechanism at the interface of nodule cell ...
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Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... RNA isolation, cDNA synthesis, and quantitative RT-PCR.Total cel- lular RNA was extracted from infected cells using the RNeasy kit (Qiagen). The concentration and purity of isolated RNA were determined spectro- ...
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Toll Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
... IMPORTANCE Toll-like receptors are a family of sensor proteins that enable the immune system to differentiate between “self” and “non-self.” Agonists and antagonists of TLRs have been proposed to have utility as ...
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Expression and activation of toll-like receptor 3 and toll-like receptor 4 on human corneal epithelial and conjunctival fibroblasts
... Interestingly, activation of HCE TLR3 and TLR4 by poly I:C and LPS, while stimulating secretion of pro- inflammatory cytokines and the up-regulation of their respective genes, was found to decrease TLRs surface ex- ...
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Review of autoantigens in Sjögren’s syndrome: an update
... muscarinic receptor-3; PGE2, prostaglandin E2; PSP, parotid secretory protein; pSS, primary Sjögren’s syndrome; qRT-PCR, qualitative reverse transcription- polymerase chain reaction; RF, rheumatoid factor; ...
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Red pitaya juice supplementation ameliorates energy balance homeostasis by modulating obesity related genes in high carbohydrate, high fat diet induced metabolic syndrome rats
... [31, 32]. Therefore, the absence of this protective factor against high-carbohydrate, high-fat diet resulted in weight gain and obesity. Gcgr is a receptor for glucagon which mediated the process of ...
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Immunoprivileged status of the liver is controlled by Toll like receptor 3 signaling
... 12 hours (F; n = 2–3 per group) later. (A) Splenocytes were analyzed by FACS for early activation marker CD25 and CD69. Histogram plots show cells gated on CD8 and Thy1.1 (marker for 318 T cells). Gray shading ...
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Toll-like receptor 3 modulates the behavioral effects of cocaine in mice
... immune receptor responsible for detecting endotoxins [50], and TLR4 directly binds to the ionotro- pic glutamate receptor N-methyl- D -aspartate (NMDA) subunit 1 (GluN1) in response to lipopolysaccharide ...
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