NOD mice
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP
... transgenic NOD mice tolerant to proinsulin, we determined that immune responses against proinsulin are necessary for IGRP-specific T cells to ...protect NOD mice from insulitis or T1D, ...
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Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
... the NOD inbred background from an original chimeric stock (17) sharing a mixed 129 and C57BL/6 ...129 mice were backcrossed to NOD mice for four ...generation. Mice from the second to ...
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Alteration of intra pancreatic target organ specificity by abrogation of Aire in NOD mice
... Aire-deficient NOD mice showed reduced expres- sion of several tissue-specific genes, including insulin, as observed in non–autoimmune-prone mouse backgrounds (13, 14, ...in NOD mice (19), the ...
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Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
... Thy1 mice were obtained through breeding of NOD/Thy1 mice with ...transgenic mice. Cat L–deficient NOD mice were generated through backcrossing the Cat L deficiency (17) onto the ...
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OdDHL Inhibits T Cell Subset Differentiation and Delays Diabetes Onset in NOD Mice
... naïve NOD T cells ...in NOD mice (4), this provides an additional mech- anism by which infections can inhibit diabetes onset in NOD mice (5, 16, ...
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Limited Effect of CpG ODN in Preventing Type 1 Diabetes in NOD Mice
... Type 1 diabetes is considered as Th1 cell mediated auto- immune disease and the suppression of Th1 cells or the activa- tion of Th2 cells has been regarded as a plausible immunologic intervention for the prevention of ...
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Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice
... female NOD mice (age 12 ...representative mice confirmed that they had extensive lymphocytic infiltration of their islets at 12 wk of age ...In mice treated with vehicle alone, diabetes onset ...
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A new model for dermatitis herpetiformis that uses HLA DQ8 transgenic NOD mice
... the NOD background and the HLA-DQ8 ...the NOD background contributes to autoimmunity and pathogenesis. Fifteen NOD DQ8+ mice of 90 that were sensitized to gluten developed blistering pathology ...
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High and low diabetes incidence nonobese diabetic (NOD) mice: Origins and characterization
... Table 4 lncidence of diabetes in FI crosses between NOD/LI and NOD/Wehi lines compared with data from a second cohort of NOD/Wehi mice which were followed longitudinally at the same time[r] ...
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Accelerated diabetes in NOD mice differing in incidence of spontaneous disease
... Splenocytes harvested from 150-day-old non-diabetic female NOD/Wehi mice were equally capable of inducing accelerated diabetes in this model, as there was no significant difference betwe[r] ...
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GAD reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice
... 3-wk-old NOD mice received two injections of purified rat brain GAD; one mouse rapidly developed dia- betes 3 wk ...against NOD-derived hybridoma cells (expressing I-A g7 ) that were transfected with ...
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Characterization and modulation of autoreactive CD4+ T cells in type 1 diabetes
... in NOD mice (French, Allison et ...young NOD mice display high reactivity to insulin, with more than 90% recognizing the insulin B chain derived peptide 9 to 23 (InsB9−23) (Wegmann, ...
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B cell depletion in autoimmune diabetes:insights from murine models
... in NOD mice than in non-autoimmune prone strains ...that NOD mice bearing an Idd11 locus derived from C57/Bl6 [76] or NOR [77] mice were resistant to diabetes, despite maintaining an ...
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Prevention of murine autoimmune diabetes by CCL22 mediated Treg recruitment to the pancreatic islets
... Type 1 diabetes is characterized by destruction of insulin-producing β cells in the pancreatic islets by effector T cells. Tregs, defined by the markers CD4 and FoxP3, regulate immune responses by suppressing effector T ...
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Reversal of established autoimmune diabetes by restoration of endogenous β cell function
... In NOD (nonobese diabetic) mice, a model of autoimmune diabetes, various immunomodulatory interventions prevent progression to ...of NOD mice impairs the presentation of self antigens and ...
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Novel therapeutic vaccine for Diabetes mellitus: Literature Review
... Now a day’s many researches are underway to develop therapeutic vaccines against diabetes mellitus. Oral delivery of auto-antigens can suppress immune activity by switching on suppressor cells of the immune system, ...
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Treatment with CD20 specific antibody prevents and reverses autoimmune diabetes in mice
... cell–depleted NOD mice, we identified what we believe is a novel mechanism by which B cell depletion may lead to long-term remission through expansion of Tregs and regulatory B ...
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Smad4 in T cells plays a protective role in the development of autoimmune Sjögren’s syndrome in the nonobese diabetic mouse
... tKO NOD mice suggests that Smad4-mediated TGF-β signaling is crucial for the development of SS but not for Th17 ...tKO NOD mice (Supplementary Figure ...tKO NOD mice were in a ...
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Recovery of a human natural antibody against the noncollagenous 1 domain of type IV collagen using humanized models
... Hu-HSC mice, although absence of nephri- tis in vivo is not a reliable indicator of anti-alpha3(IV) NC1 Ab pathogenicity in this ...in mice and strain ...[12]. NOD mice in particular, the ...
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Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice
... 12-week-old NOD mice left untreated or infected 21 days previously with CVB3 or ...12-week-old NOD mice left untreated or infected 21 ...
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