Node Positive Breast Cancer
Targeting and limiting surgery for patients with node-positive breast cancer
... clipped node with documented metas- tases before NCT in addition to SLND lowers the FNR over SLND ...clipped node could not be identified as a sentinel node using dual mapping agents or ...the ...
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Cyclophosphamide metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node positive breast cancer: a retrospective cohort study
... ever, this study of 124 subjects had only three individuals who carried a CYP3A4*1B variant and was thus under- powered to examine this association. Ambrosone and colleagues evaluated the role of GSTM1- and GSTT1- null ...
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Validation of the Memorial Sloan Kettering Cancer Center nomogram for predicting non-sentinel lymph node metastasis in sentinel lymph node-positive breast-cancer patients
... MSKCC nomograms can be widely used in SLN-positive patients for the prediction of non-SLN metastasis, and exhibit high reference values for clinical decision making. However, they cannot be used as a clinical ...
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Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy : results from the BIG 02-98 phase III trial
... early breast cancer have reported a predictive role for TP53 muta- ...triple-negative breast cancers patients treated with neoadjuvant cisplatin, nonsense and frameshift TP53 mutations were ...
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Usefulness of Breast MRI for Safe Omission of Axillary Lymph Nodes Dissection in Sentinel Node Positive Breast Cancer Patients
... lymph node metastasis (LNM) is important for safe omission of axillary lymph node dis- section (ALND) in sentinel node (SN)-positive (SN+) breast cancer ...758 breast ...
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Prognostic and predictive value of TP53mutations in node positive breast cancer patients treated with anthracycline or anthracycline/taxane based adjuvant therapy: results from the BIG 02 98 phase III trial
... early breast cancer have reported a predictive role for TP53 muta- ...triple-negative breast cancers patients treated with neoadjuvant cisplatin, nonsense and frameshift TP53 mutations were ...
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Protein expression, survival and docetaxel benefit in node positive breast cancer treated with adjuvant chemotherapy in the FNCLCC PACS 01 randomized trial
... interaction) in Ki67-positive ER-positive patients enrolled in the PACS01 trial has been reported [30]. Our present analysis, applied to all available PACS01 samples regardless of the ER status, showed a ...
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Retained Intrauterine Foetal Bones: A Review of Literature
... tumour positive sentinel lymph node biopsy without axillary treatment ; a review of the literature ...lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for ...
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Original Article Lymphangiogenesis in breast cancer is associated with non-sentinel lymph node metastases in sentinel node positive patients
... lymph node (SLN) surgery has become the standard of care for axillary staging of women with clinically node-negative (cN0) breast ...is positive, axillary lymph node dissection (ALND) ...
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c-Met overexpression in breast cancer with positive axillary lymph node
... In addition, c-Met tyrosine kinase plays a role in invasive tumor growth, through a series of complex physiological programs that regulate cell proliferation activity, survival, invasion, and angiogenesis. According to ...
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Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour
... We add here some important details to the previously reported investigation on the recurrence risk pattern of this same series [12]. Indeed, we found that even though pre- menopausal and post-menopausal patients display ...
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Better survival after breast conserving therapy compared to mastectomy when axillary node status is positive in early stage breast cancer: a registry based follow up study of 6387 Norwegian women participating in screening, primarily operated between 1998 and 2009
... that cancer detected on first screening could have different clinophatological features compared to later screening-detected cancer and interval ...interval cancer and may be a confounding factor. A ...
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Elaboration of a nomogram to predict non sentinel node status in breast cancer patients with positive sentinel node, intra-operatively assessed with one step nucleic acid amplification method
... Recently, ASCO guidelines for SLNB and ALND have been published, indicating the patients with micro and macrometastases (only those that meet Giuliano criteria) may avoid ALND, but many controversies still remain [18]. ...
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Original Article USP7 promotes tumorigenesis in breast cancer and enhances MRI detection
... in breast carcinoma is still ...that breast carcinoma express high levels of ...lymph node metastasis, tumor stage and tumor size were positive associated with high USP7 ...the breast ...
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Adjuvant Taxanes in Breast Cancer: A Critical Re appraisal
... a positive im- pact for taxanes in adjuvant breast cancer treatment in terms of reduced recurrence rates and ...axillary node involvement and hormone receptor ...
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Early Results of Omitting Completion Axillary Lymph Node Dissection in Sentinel Lymph Node Metastasis Positive Breast Cancer Patients
... was positive for metastasis following the sur- gery, the patient was allowed to choose one of two treatment options: 1) performance of completion ALND, followed by performance of adjuvant therapy, or 2) per- ...
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Correlation of Breast Cancer Subtypes Based on ER, PR and HER2 Expression with Axillary Lymph Node Status
... of breast cancer subtypes and different clinicopathological parameters is important, because it provides valuable prognostic and predictive ...triple positive breast carcinomas are more likely ...
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SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF C in mouse models of breast cancer
... human breast cancer cell line, MCF7, primarily induced lymphatic metastasis, with some distant metastasis, when cells were orthotopically injected into nude or NOD/SCID mice ...with positive lymph ...
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A robust prognostic signature for hormone-positive node-negative breast cancer
... 2,175 breast cancer samples were ...ER+, node-negative, and had not received systemic chemotherapy, 1,403 samples ...be positive for in- clusion in further ...
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COMPARATIVE ANALYSIS OF LYMPH NODES POSITIVE AND LYMPH NODE NEGATIVE BREAST CANCER
... Gross examination was done according to standard College of American Pathologists (CAP) protocol with special emphasis on tumor size, skin, nipple and lymph node involvement and confirmed later with ...
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