NON-SELECTIVE COX INHIBITORS:
Should selective Cox-2 inhibitors be used more?
... that COX-2 enzyme induced only at inflammatory site, but it is now known that like COX-1, COX-2 can also be constitutively expressed in a variety of non-inflammatory tissues, including kidney, ...
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2D QSAR STUDY OF INDOLE DERIVATIVES AS SELECTIVE COX 2 INHIBITORS
... of COX-2, while the adverse effects of these agents, particularly in the upper GI tract, arise from inhibition of COX-1 activity 2 ...produce selective inhibitors of cyclooxygenase-2 ...
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QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors
... of COX enzyme as a highly suitable target in anti-inflammatory ...Although COX-2 is concerned to be the main isoenzyme related to inflammation, most NSAIDs in the market today block both forms of COX ...
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Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors
... Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used therapeutics. Through their anti- inflammatory, anti-pyretic and analgesic activities, they represent a choice treatment in various ...
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Effects of non-selective (piroxicam) and selective (meloxicam) cyclo-oxygenase inhibitors on the intestinal contractility of rabbits
... SC-560, selective COX-1 inhibitor, was devoid of significant effects on ileal ...motility. Selective COX-2 inhibitors reduced both tonic contraction and spontaneous phasic contractions ...
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Synthesis and preliminary evaluation of potential highly selective COX 2 inhibitors of some nonsteroidal anti inflammatory derivatives
... involve selective COX-2 inhibitors and TNSAIDS in treatment of inflammatory condition, in which COX-2 inhibitors such as Rofecoxib and Celecoxib showed promised equivalent efficacy ...
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COX SELECTIVE ANTIINFLAMMATORY DRUGS AND ITS DEVELOPMENT
... of non- selective NSAIDs, the COX-2 inhibitors have two major structural motifs: the acidic methanesulfonamide (Me- SO 2 NH) containing diphenylethers exemplified by nime- sulide 32, 33 and ...
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Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids
... against COX enzymes for anti- inflammatory discovery using molecular docking ...both COX binding ...(cSI). Selective COX-2 inhibitors, respectively, are (1) ...
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Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis
... in non-small-cell lung cancer (NSCLC) have been found to exhibit increased COX-2 ...4 COX-2 expression in tumors appears to be instrumental in tumor resistance to apoptosis, angiogen- esis, invasion, ...
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Health Related Quality of Life among Osteoarthritis Patients: A Comparison of Traditional Non Steroidal Anti Inflammatory Drugs and Selective COX 2 Inhibitors in the United Arab Emirates Using the SF 36
... the selective COX-2 inhibitors, celecoxib and etoricoxib are the only two medications in this class available in the UAE ...on selective COX-2 inhibitors which may explain the ...
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Exploring Structural Parameters for Designing Cox 1 and Cox 2 Inhibitors: Pharmacophoric Modeling, Virtual Screening and Docking Study
... as COX-1 inhibitors and 01 bioactive as COX-2 ...deciding COX- 1/COX-2 selectivity based on binding energy increase the chances of reducing potential side effects of ...
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Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
... of COX-2 is a common character- istic of many human carcinomas. COX-2 plays an im- portant role in tumorigenesis as mediating the progression and metastasis of tumors, such as nasopha- ryngeal carcinoma ...
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Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
... P-gp inhibitors resulted in increased phenytoin concentration in brain extracellular fluid (ECF) in rats ...with selective P-gp in- hibitor, tariquidar, improved seizure control in chronic epileptic rats ...
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Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
... Keywords: inflammation, breast cancer, colon cancer, prostate cancer, lung cancer, chemo prevention Introduction Vane discovered that the anti-inflammatory effects of aspirin-like drugs are primarily due to their ...
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Synthesis, Cyclooxygenase Inhibition, Anti inflammatory Evaluation and Gastric Liability of Some Novel Indole Derivatives as Selective COX 2 Inhibitors
... of COX-2, exhibited the most anti-inflammatory and selectivity actives so, they were more evaluated by calculating their ED 50 % doses and ulcerogenic indices to ensure their gastric safety margin relative to ...
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Microbial Metabolism of Rofecoxib, A Selective COX-2 Inhibitor
... 13 C NMR showed seventeen resonances distributed as one methyl, one methylene, eight aromatic methines, and one oxygenated aromatic quaternary carbon. Other quaternary carbons were almost identical to those of the parent ...
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Review of Selective Serotonin Reuptake Inhibitors
... Selective serotonin reuptake inhibitors (SSRIs) are amongst the most widely prescribed class of antidepressants worldwide. Their extensive use is due to their better safety and effectiveness profile when ...
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Synthesis and biological evaluation of 4 (substituted phenylsulfamoyl) 2 hydroxyphenyl acetate derivatives as potent anti inflammatory and selective COX 2 inhibitors
... whereas COX-2 is inducible and plays a major role in PG biosynthesis in inflammatory ...of COX-1 causes unfavorable GIside effects ...on selective COX-2 inhibitors which are believed to ...
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Prescriptions for selective cyclooxygenase 2 inhibitors, non selective non steroidal anti inflammatory drugs, and risk of breast cancer in a population based case control study
... number of days from the date of a first prescription to the date of a last prescription plus the duration of the last prescription. We divided duration of NSAID use into long-term (10 to less than or equal to15 years, ...
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Prescriptions for Selective Cyclooxygenase-2 Inhibitors, Non-Selective Non-Steroidal Anti-Inflammatory Drugs, and Risk of Breast Cancer in a Population-Based Case-Control Study
... sCox-2 inhibitors on breast cancer risk reported a risk reduction of at least 20% ...sCox-2 inhibitors when they became available to avoid any adverse side-effects, a reduced risk of breast cancer in such ...
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