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non-stem cancer cell

Non-stem cancer cell kinetics modulate solid tumor progression

Non-stem cancer cell kinetics modulate solid tumor progression

... for non-zero migration rates, resulting in a non-monotonic dependence of the growth kinetics on the depth of the CC ...with non-stem proliferative capacities either lower or higher than the ...

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A High Performance Cellular Automaton Model of Tumor Growth with Dynamically Growing Domains

A High Performance Cellular Automaton Model of Tumor Growth with Dynamically Growing Domains

... 0.1. Non-stem daughter cells are initialized with trait vector [cct = 24 hours, ρ = 10, μ = 100 μm/day, α = ...[22-24]. Cell cycle time and migration rate can be measured experimentally [17], while ...

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Cancer stem cell metabolism

Cancer stem cell metabolism

... inhibit tumour formation [29, 42–44]. Treatment with metformin, an inhibitor of the OXPHOS complex I, in- duces the partial suppression of stemness traits, such as mammosphere formation, and in-vivo tumour growth delay, ...

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Original Article Prognostic value of Thy1 in non-small cell lung cancer: a RNA-Seq transcriptome analysis

Original Article Prognostic value of Thy1 in non-small cell lung cancer: a RNA-Seq transcriptome analysis

... regulate cell-matrix and cell-cell ...of cancer stem ...in non small cell lung cancer (NSCLC), we cultured the stem cell-like sphere 95D cell ...

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Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

... unscheduled cell division in progenitor cells ...ovary cancer cells, stem-like CD24- cells or spher- oids highly expressed cyclin D1, Bmi-1, and vimentin with reduced expression of E-cadherin, while ...

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Cancer stem cell metabolism

Cancer stem cell metabolism

... which non-glycolytic stem-like cells may be fed by more differentiated glycolytic cells in normoxic conditions has also been observed in breast cancer ...EMT-induced cancer cells with CSC ...

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Differentiation and transdifferentiation potentials of cancer stem cells

Differentiation and transdifferentiation potentials of cancer stem cells

... partial stem cell-like properties. In breast cancer, EMT provides a nonmalignant ...GFP-labeled cancer cells [66]. Although EMT- transformed cancer cells can serve as CAFs, there is no ...

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Brca1 breast tumors contain distinct CD44+/CD24  and CD133+cells with cancer stem cell characteristics

Brca1 breast tumors contain distinct CD44+/CD24 and CD133+cells with cancer stem cell characteristics

... normal stem cells through differentiation with generation of progenitor and termi- nally differentiated cells, multistep carcinogenesis is likely to generate heterogeneity in cancer-initiating population, ...

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Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells

Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells

... asymmetric cell division is based on the assumption that CSCs and non-CSCs are epigeneti- cally stable and can thus propagate in a mutually inde- pendent ...established cancer cell lines or in ...

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Ovarian cancer stem-like cells with induced translineage- differentiation capacity and are suppressed by alkaline phosphatase inhibitor

Ovarian cancer stem-like cells with induced translineage- differentiation capacity and are suppressed by alkaline phosphatase inhibitor

... glioma stem cells (GSCs), in which the mesenchymal type GSCs are more aggressive and tumorigenic than the proneural type ...different cancer stem cell ...of cancer stem-like ...

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Cancer stem cells in solid tumors: elusive or illusive?

Cancer stem cells in solid tumors: elusive or illusive?

... the cell mem- brane ...hematopoietic stem cells are particularly effective at pumping out Hoechst [51] since they express high levels of ABC transporters resulting in a small side population of weakly ...

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Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits

Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits

... Prostate Tumor Overexpressed 1 (PTOV1) was ini- tially identified during screening for genes overexpressed in prostate cancer [14]. PTOV1, a 46 KDa protein with two repeated PTOV homology blocks of 151 and 147 ...

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The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo

... for cancer stem cell inhibition, it is also possible that AS602801 has a unique off-target effect(s) that also contributes to the inhibition of cancer stem ...control cancer ...

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Lung cancer stem cells and low-intensity laser irradiation: a potential future therapy?

Lung cancer stem cells and low-intensity laser irradiation: a potential future therapy?

... The two types of lung cancer associated with smoking are small cell lung cancer (SCLC) and non-small cell lung can- cer (NSCLC). SCLC is characterized by very rapid tumor growth and is ...

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Review Article Clinicopathological and prognostic significance of cd133 in esophageal cancer: a meta-analysis

Review Article Clinicopathological and prognostic significance of cd133 in esophageal cancer: a meta-analysis

... for cancer therapy, as our recently available therapies are more suc- cessful at eradicating non-cancer stem cells rather than cancer stem cells [4, ...for cancer [6]. ...

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NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells

NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells

... was observed between the presence of NOTCH1 in tumor tissue and other clinicopathologic features, such as tumor size, regional lymph nodes, recurrence, ER, PR, or HER2, nor was there any statistical association between ...

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Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

Cyclin D1 affects epithelial–mesenchymal transition in epithelial ovarian cancer stem cell-like cells

... Ovarian adenocarcinoma cell line 3AO was obtained from the Women’s Hospital, School of Medicine, Zhejiang University. Cells were maintained in RPMI 1640 medium, supplemented with 10% fetal bovine serum. The ...

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Epigenetic regulation in adult stem cells and cancers

Epigenetic regulation in adult stem cells and cancers

... been shown to maintain the cyclical nature of hair follicle regeneration. Using chromatin immunoprecipitation, fol- lowed by ChIP-seq, a high-throughput sequencing tech- nique, chromatin changes upon transition from ...

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Hematopoietic stem cells and retroviral infection

Hematopoietic stem cells and retroviral infection

... The development of ATLL correlates with neonatal or perinatal transmission of HTLV-1. HTLV-1 carries no cellular proto-oncogenes, and the oncogenic potential of the virus is linked to Tax1, a 40 kDa protein that func- ...

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Effect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells

<p>Effect of overexpression of Oct4 and Sox2 genes on the biological and oncological characteristics of gastric cancer cells</p>

... germ cell tumors and metastatic ...breast cancer, high Oct4 expression led to increased tumorigenic ability compared to low Oct4 ...liver cancer cells decreased their tumori- genic and invasive ...

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