Noncoding RNAs
The functions of long noncoding RNAs in development and stem cells
... Hox genes encode TFs that orchestrate the embryo body plan and contribute to several adult cell fate specification processes (Barber and Rastegar, 2010). In addition to containing protein-coding and miRNA genes, these ...
13
Noncoding RNAs of the Ultrabithorax Domain of the Drosophila Bithorax Complex
... Several noncoding RNAs have been identified within the Drosophila bithorax ...these noncoding RNAs have a role in establishing active domains, perhaps by setting the state of Polycomb Response ...
12
Long noncoding RNAs and neuroblastoma
... long noncoding RNAs (lncRNAs) have become the cutting edge of cancer research with inroads made in understanding their roles in multiple cancer types, including prostate and breast ...
11
Expression profiles and initial confirmation of long noncoding RNAs in Chinese patients with pulmonary adenocarcinoma
... long noncoding RNAs (lncRNAs) in pulmonary adenocarcinoma tissue and adjacent noncancerous tissue from Chinese patients using lncRNA expression microarray and preliminary ...
10
Noncoding RNAs in prostate cancer: the long and the short of it
... namely noncoding RNAs (ncRNA), is emerging as a key player in cancer initiation and progression and boasts many attractive features for both biomarker and therapeu- tic ...
10
Identifying cancer-causing noncoding RNAs
... In 2006, 5 research groups discovered another class of noncoding RNAs (Aravin et al., 2006; Girard et al., 2006; Grivna et al., 2006; Lau et al., 2006; Watanabe et al., 2006). These Piwi-in- teracting ...
136
Insights into long noncoding RNAs of naked mole rat ( Heterocephalus glaber ) and their potential association with cancer resistance
... In order to comprehensively identify NMR lncRNAs, 12 transcriptomes of three tissues (kidney, liver, and brain) from newborn, 4-year-old, 4-year-old with low-oxygen- treated and 20-year-old NMRs were collected [3] (Addi- ...
10
Functions and mechanisms of long noncoding RNAs in lung cancer
... Long noncoding RNAs (lncRNAs) are emerging as an important set of molecules because of their roles in various key pathophysiological pathways, including cell growth, apoptosis, and ...
14
Long noncoding RNAs coordinate functions between mitochondria and the nucleus
... In animal cells, mitochondria are the primary powerhouses and metabolic factories. They also contain genomes and can produce mitochondrial‑specific nucleic acids and proteins. To maintain homeostasis of the entire cell, ...
11
IDENTIFICATIN OF HUMAN LARGE INTERGENIC NONCODING RNAS
... Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse cellular processes.Determining the function of individual lincRNAs remains a challenge. Recent advances in RNA sequencing ...
10
Gammaherpesvirus Small Noncoding RNAs Are Bifunctional Elements That Regulate Infection and Contribute to Virulence In Vivo
... express noncoding RNAs ...these RNAs to infection and pathogenesis remains largely ...these RNAs to ␥HV infection, we have used ␥ HV68, a small-animal model of ␥ HV ...these RNAs as a ...
15
Extracellular vesicles-mediated noncoding RNAs transfer in cancer
... Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including ...
11
Role of Noncoding RNAs in Chronic Pancreatitis
... newer noncoding RNAs, mostly long noncoding RNAs, are being discovered with the help of advanced technologies, it has become imperative to determine their exact functional role, elucidation of ...
11
Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer
... “noncoding RNAs” (ncRNAs) are a group of RNAs that do not code for proteins, and they are categorized as structural RNAs and regulatory ...regulatory RNAs to affect the progression of ...
9
Regulation of PTEN expression by noncoding RNAs
... endogenous RNAs; CK2: Formerly casein kinase II; CSCs: Cancer stem cells; DNMTs: DNA methyltransferases; ECM: Extracellular matrix; EMT: Mesenchymal transition; eNOS: Endothelial nitric oxide synthase (eNOS); ...
12
Investigating long noncoding RNAs using animal models
... (or noncoding RNA) is mostly obscure, despite a larger number of noncoding genes than protein-coding ...for noncoding RNAs also span diverse cellular process- es, resulting in an array of ...
10
A Novel Class of Developmentally Regulated Noncoding RNAs in Leishmania
... the RNAs (reviewed in reference ...these RNAs are likely to be trans spliced to generate the smaller RNA species seen in Northern blot hybridizations ...for noncoding RNAs, all cDNA clones ...
14
Landscape of tumor suppressor long noncoding RNAs in breast cancer
... In our previous study, the oncogenic lncRNA land- scape was identified and validated in breast cancer [10]. Moreover, we also identified an lncRNA, linc00152, which functions as a tumor propellant in breast cancer and ...
18
T-ALL and thymocytes: a message of noncoding RNAs
... long noncoding RNAs (lncRNAs) such as XIST (implicated in X-chromosome inactivation) has been known for some time [32, 33], the full recognition for lncRNAs as functionally relevant RNA molecules has only ...
17
Comprehensive Identification of Meningococcal Genes and Small Noncoding RNAs Required for Host Cell Colonization
... ABSTRACT Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia, affecting infants and adults world- wide. N. meningitidis is also a common inhabitant of the human nasopharynx and, as such, is ...
13