noninferiority trial
Evaluating the therapeutic efficacy of the Chinese herbal medicine Yishen Tongbi decoction in patients with active rheumatoid arthritis: protocol for a randomized, controlled, noninferiority trial
... This study is a double-blind, randomized controlled, noninferiority trial. One hundred eligible patients with RA will be randomized into two groups of 50 patients. One group will receive Yishen Tongbi ...
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When an Asthma Drug Has an Inferiority Complex: A Noninferiority Trial
... randomized trial to compare the efficacy of oral mon- telukast and inhaled fluticasone in children 6 to 14 years old with mild persistent ...a noninferiority trial, a relatively recent study design ...
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Comparison of the efficacy of once and twice daily colchicine dosage in pediatric patients with familial Mediterranean fever – a randomized controlled noninferiority trial
... controlled noninferiority trial, pediatric patients newly diagnosed with FMF carrying a homozygous or compound heterozygous mutation and not receiving any treatment were ...
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Prophylaxis After First Febrile Urinary Tract Infection in Children? A Multicenter, Randomized, Controlled, Noninferiority Trial
... 2-armed, noninferiority trial comparing no prophylaxis with prophylaxis (co-trimoxazole 15 mg/kg per day or co-amoxiclav 15 mg/kg per day) for 12 ...
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Comparison of a group-delivered and individually delivered lifestyle-integrated functional exercise (LiFE) program in older persons: a randomized noninferiority trial
... assessed by the Late-Life Function and Disability Instru- ment (LLFDI) [57]; balance self-efficacy is assessed using the Activities-specific Balance Confidence Scale [ABC-S- cale] [58]. Health-related resource use will ...
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Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial
... Results: 189 (67.3%) formula-fed infants were included in the primary analysis. Mean differences in weight gain between the control and IF-BMOS and IF-BMOS + Pro groups were <1 g/day, with 97.5% confidence intervals ...
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Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial
... sumed an RSV hospitalization rate of 3% in palivizumab recipients 5,6,15 with a 45% reduction of RSV hospitalization by motavizumab compared with palivi- zumab.. 4–6 Assuming a 5% dropou[r] ...
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Concomitant food intake does not affect the efficacy of entecavir in chronic hepatitis B patients with virological response: a randomized, multicenter, noninferiority trial
... The present study evaluated whether entecavir administration in the fed state had comparable efficacy to the fasted condition for maintenance of viral suppression in HBV-infected patie[r] ...
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Asthma control in adolescents: role of leukotriene inhibitors
... The Montelukast Study of Asthma in Children (MOSAIC) was a 12-month, multicenter, double-blind, noninferiority trial to determine the effect of once-daily, orally adminis- tered m[r] ...
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PubMedCentral-PMC5787861.pdf
... on noninferiority trials. The goal of noninferiority trial is not only to show that the new drug is noninferior to the active control, but also to show more importantly that the new drug is better ...
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Equivalence and noninferiority trials – are they viable alternatives for registration of new drugs? (III)
... A trial that is intended to demonstrate noninferiority may actually allow a claim of superiority for the test ...a noninferiority trial is, in fact, superiority to "no treatment," ...
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Use of transdermal and intravenous granisetron and the ability of the Hesketh score to assess nausea and vomiting induced by multiday chemotherapy
... III noninferiority trial of GTDS versus oral granisetron in patients receiving 3 days of multi- agent moderately or highly emetogenic chemotherapy, regardless of granisetron ...
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The role of insulin glulisine to improve glycemic control in children with diabetes mellitus
... group, noninferiority trial of 572 children and adolescents, aged 4 to 17 years with type 1 diabetes using glargine once daily in the evening or NPH twice daily as basal insulin and glulisine or lispro as ...
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Bayesian Noninferiority Testing and Nonparametric Survival Regression using Bernstein Polynomials.
... Bayesian type I error is a weighted average of classical type I error, so it still can not serve the purpose of controlling the maximum error that is required by most regulatory agencies. Alternatively, in this paper we ...
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Impact of different restorative treatments for deep caries lesion in primary teeth (CEPECO 1) – study protocol for a noninferiority randomized clinical trial
... This clinical trial was approved by the local ethical board committee from the Faculty of Dentistry of the Ibira- puera University (registration no. 1.670.059). Participants will be included after their legal ...
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Interpreters: Telephonic, In-Person Interpretation and Bilingual Providers
... METHODS: This was a prospective, randomized trial. The setting was an urban pediatric emergency department at which ⬃ 20% of visits are by families with limited English proficiency. The participants were families ...
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65Plus: open-label study of bevacizumab in combination with pemetrexed or pemetrexed/carboplatin as first-line treatment of patients with advanced or recurrent nonsquamous non-small-cell lung cancer
... Based on the data available for combination therapy with Bev, a median PFS of 5.5 months for BevCPem was expected. Tak- ing into account the available data on PFS in the literature, a difference of 1.5 months seemed ...
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Efficacy and safety of tigecycline monotherapy vs imipenem/cilastatin in Chinese patients with complicated intra abdominal infections: a randomized controlled trial
... open-label trial of hospitalized Chinese patients at least 18 years of age who were candidates for or had undergone a laparot- omy, laparoscopy, or percutaneous drainage of an intra- abdominal abscess and had a ...
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Role of lipegfilgrastim in the management of chemotherapy-induced neutropenia
... No significant difference in the duration of severe neu- tropenia for the first chemotherapy cycle among the three lipegfilgrastim doses and pegfilgrastim was observed. The percentage of patients who did not experience ...
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Pharmacokinetics of Micafungin in Adult Patients with Invasive Candidiasis and Candidemia
... C. Barrios, D. Raghunadharao, J. S. Sekhon, A. Freire, V. Ramasubramanian, I. Demeyer, M. Nucci, A. Leelarasa- mee, F. Jacobs, J. Decruyenaere, D. Pittet, A. J. Ullmann, L. Ostrosky-Zeichner, O. Lortholary, S. Koblinger, ...
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