Nonsense mediated mRNA decay
UPF2, a nonsense mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome
... Nonsense-mediated mRNA decay (NMD) represents a highly conserved RNA surveillance mechanism through which mRNA transcripts bearing premature termination codons (PTCs) are selectively ...
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Regulation of Natural mRNAs by the Nonsense-Mediated mRNA Decay Pathway
... The nonsense-mediated mRNA decay (NMD) pathway is a specialized mRNA degradation pathway that degrades select ...the mRNA, NMD is now also recognized as a pathway that degrades ...
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Nonsense mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin
... (CFTR) nonsense transcripts is markedly reduced, while in others it is significantly ...the nonsense-mediated mRNA decay (NMD) might vary among cells and hence governs the level of ...
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Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease
... that mRNA transcripts with PTCs are tar- gets for nonsense-mediated mRNA decay ...all mRNA molecules and is displaced by the ribosome during the pioneer round of translation ...
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A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans
... mediating nonsense-mediated mRNA decay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which are at the apex of DNA damage signaling ...
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Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution
... Nonsense-mediated mRNA decay (NMD) is an essential eukaryotic process regulating transcript quality and abundance, and is involved in diverse processes including brain development and plant ...
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Gene Set Coregulated by the Saccharomyces cerevisiae Nonsense-Mediated mRNA Decay Pathway
... The nonsense-mediated mRNA decay (NMD) pathway has historically been thought of as an RNA surveil- lance system that degrades mRNAs with premature translation termination codons, but the NMD ...
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Assessing the activity of nonsense-mediated mRNA decay in lung cancer
... of nonsense-mediated mRNA decay (NMD) in tumor cells can suppress tumor growth through expressing new antigens whose mRNAs otherwise are degraded by ...
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Premature termination codons in PRPF31 cause retinitis pigmentosa via haploinsufficiency due to nonsense mediated mRNA decay
... Blocking nonsense-mediated mRNA decay significantly restored the amount of mutant PRPF31 mRNA but did not restore the synthesis of mutant proteins, even in conjunction with inhibitors ...
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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay
... as nonsense-mediated mRNA decay (NMD), 2–4 which reduces the expression of the corres- ponding gene to a low ...the mRNA level, PTCs can arise from errors in transcription, ...
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Nuclear Import of Upf3p Is Mediated by Importin-α/-β and Export to the Cytoplasm Is Required for a Functional Nonsense-Mediated mRNA Decay Pathway in Yeast
... 3p Nonsense mRNA degradation occurs through a pathway are required for NMD (Leeds et ...called nonsense-mediated mRNA decay (NMD), which ...stabilize nonsense ...
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A role for nonsense mediated mRNA decay in plants : pathogen responses are induced in Arabidopsis thaliana NMD mutants
... As sessile organisms, plants are arguably more dependent on rapid changes in gene expression in response to biotic and abiotic stressors. This is reflected in the aggressive nature of the hypersensitive response, in ...
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Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
... These results suggest that NMD targets different genes in the two species, but ones largely in the same functional categories (Table 9 and Additional file 4). While superfi- cially this looks like evidence for regulated ...
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The Human T-Lymphotropic Virus Type 1 Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1
... HBZ mRNA promotes T-cell proliferation (55), while the HBZ protein suppresses Tax-mediated viral transcrip- tion ...UPF1- mediated degradation. This suggests that viral mRNA expression ...
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Nonsense-Mediated mRNA Decay Mutation in Aspergillus nidulans
... ⬘ nonsense mutations trigger higher rates of mRNA decapping than 3 ⬘ nonsense mutations in ...⬘ nonsense mutations can fail to provoke NMD, since 5 ⬘ -to-3 ⬘ exonucleolytic decay is the ...
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Killing the messenger: new insights into nonsense mediated mRNA decay
... precursor mRNA molecules and mRNA molecules as lonely travelers in a complex nucleus, this image could hardly be farther from the ...nascent mRNA is modified (“capped”), and a protein complex ...
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smg-7 Is Required for mRNA Surveillance in Caenorhabditis elegans
... “nonsense-mediated mRNA decay” (NMD) or “mRNA ...Whereas nonsense mutant mRNAs are unstable in smg(1 ) genetic backgrounds, such mRNAs have normal stability in smg(2 ) ...
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Accumulation of mRNA Coding for the Ctf13p Kinetochore Subunit of Saccharomyces cerevisiae Depends on the Same Factors That Promote Rapid Decay of Nonsense mRNAs
... with nonsense-medi- ated mRNA ...pre- mRNA was used as a diagnostic indicator of a functional nonsense-mediated mRNA decay ...non-sense- mediated decay ...
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Identification and quantitative mRNA analysis of a novel splice variant of GPIHBP1 in dairy cattle
... Commonly, alternative splicing may change the struc- ture of transcripts of a gene and the protein encoded by the gene, leading to profound functional alternation. It has been demonstrated that alternative splicing could ...
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Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations
... Upf2 mRNA by 80–90% caused mild to severe toxicity, demonstrated by less body weight gain and ele- vated plasma ALT and AST levels compared to control- ASO treated mice (Additional file 2: Table ...Upf2 ...
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