Normal and osteoarthritic joint
Light on osteoarthritic joint: from bench to bed
... between normal rat knee joints and OA joints [77, ...with normal joints, the sponge layer expresses considerably stronger PA signals in the OA joints, while the US reflections are almost identical in two ...
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An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint
... 44 Wakitani et al., were among the first to demonstrate the possible use of BM-MSCs for treating full thickness cartilage defects in an animal model 296 . Numerous human studies have assessed the use of MSCs as either ...
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Identification of new reference genes for the normalisation of canine osteoarthritic joint tissue transcripts from microarray data
... 18. Gorzelniak K, Janke J, Engeli S, Sharma AM: Validation of endog- enous controls for gene expression studies in human adi- pocytes and preadipocytes. Horm Metab Res 2001, 33:625-627. 19. Matyas JR, Huang D, Adams ME: ...
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The role of aggrecan in normal and osteoarthritic cartilage
... Keywords: Aggrecan; Link protein; Hyaluronan; Matrix metalloproteinase; Aggrecanase; Age changes; Articular cartilage; Osteoarthritis Background This review describes the role of aggrecan in the function of articular ...
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Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage
... In advanced osteoarthritis, all of the cartilaginous components are lost from the joint surface. Although mechanisms exist for proteoglycan degradation, there is not known to be any system for removal of the ...
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Non-invasive mechanical joint loading as an alternative model for osteoarthritic pain
... Statistical analysis Data were analysed using GraphPad Prism (7.04). Results are presented as mean ± SEM. Mice were assigned conditions in a pseudo-random order, ensuring comparable behavioural baseline values and ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... The increased expression of BGN, CSPG2, CTSB, DCN, LUM, MMP13, and TNC is consistent with previous studies of expression of these genes in both naturally occurring human [35-39] and experimental canine OA [30-32]. The ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... The increased expression of BGN, CSPG2, CTSB, DCN, LUM, MMP13, and TNC is consistent with previous studies of expression of these genes in both naturally occurring human [35-39] and experimental canine OA [30-32]. The ...
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Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage
... excluded. Normal cartilage was obtained from the femoral condyles and tibial pla- teaus of healthy organ donors or at autopsy from donors with no known history of joint ...
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Expression of novel extracellular sulfatases Sulf 1 and Sulf 2 in normal and osteoarthritic articular cartilage
... decreased with joint maturation, suggesting a role in this proc- ess. By 12 months of age, Sulf expression increased again with the simultaneous development of OA-like changes. Taken together, these findings from ...
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Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid
... the joint surface articular ...if normal and arthritic joints demonstrate unique MMPs expression profiles, and if so, can the MMP expression profile be used to identify patients with early ...
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Aggrecan degradation in human cartilage Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints
... undergoing joint replacement surgery for OA or ...thickness joint cartilage samples were immersed in OCT embedding medium and snap frozen on liquid ...the joint through the loaded area towards the ...
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The assessment of instability in the osteoarthritic knee
... normal proprioception in the subjectively unstable knee 2,19 may lead to patient recognition of feelings of buckling and instability that may or may not lead to falls, leading to the voluntary reduction of ...
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Do MRI features at baseline predict radiographic joint space narrowing in the medial compartment of the osteoarthritic knee 2 years later?
... Radiographic progression Baseline and 2-year knee radiographs were scored for medial JSW on a scale of 0 (normal)–3 (total JSN) with help of the Osteoarthritis Research Society International (OARSI) atlas [ 19 , ...
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The young osteoarthritic knee: dilemmas in management
... the normal knee, loads that are over twice body weight are imposed on the tibio-femoral joint during ...knee joint ’ s load passes through the medial tibial pla- teau ...
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Collagen synthesis in normal and osteoarthritic human cartilage
... in osteoarthritic human articular cartilage was compared to that in normal cartilage and was also correlated with the degree of severity of the osteoarthritic lesion as determined by a ...
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Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
... Conclusions Our potential miRNAtarget predictions and the signal- ling cascades (previously published in the literature to be involved in development, maintenance degradation of cartilage) altered by the differentially ...
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Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes
... for normal skeletal development; since they generated cartilage-specific Dicer-null mice that showed a greatly decreased chondrocyte proliferation and accelerated hypertrophy leading to severe growth defects and ...
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Osteoarthritic Joint Pain: Advances in Diagnosis & Treatment. Michael Bottros, MD
... Explain the role of radiofrequency ablation in the treatment of facet and peripheral joint pain, as well as persistent post-surgical pain syndromes.... Facet Joints.[r] ...
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VTNJ variably truncated normal joint
... of normal distribution, the conventional truncated normal estimator worked well only if the sample size is greater than ...truncated normal joint probability distribution function, composing ...
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