Notation for the Kv4.3/KChIP2 potassium channel
A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit
... The Kv4 channel and the KChIP subunit diversified during vertebrate evolution Since the mammalian genome contains three Kv4 paralogues and four KChIP paralogues, while the genome of Ciona ...
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Potassium Channel and Glioma
... study, potassium channels are the best characterized with established role in cell cycle ...regulation. Potassium channels are transmembrane proteins that are defined by their ability to selectively ...
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An overview of the potassium channel family
... + channel automatically implies a negative-going change in electrical voltage across the cell ...+ channel, probably for volume regulation and maintenance of cell ...
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Potassium channel-based optogenetic silencing
... nucleotide-gated potassium channel ...sustained potassium-mediated hyperpolarization, conferring high operational light sensitivity to the cells of ...
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A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels
... + channel interacting proteins (KChIPs) are EF hand-containing proteins required for the traffic of channel-forming Kv4 K + subunits to the plasma ...by Kv4/KChIP1 traffic, we examined their ...
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Potassium channel blockers as potential antisickling agents
... calcium channel blocker, was also shown to block IKca in red blood cells with A23187 stimulated K+ efflux at 100 pM, and in addition, inhibits Ca^+- dependent binding of calmodulin to the erythrocyte ...
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In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... ABSTRACT Kappa actitoxin Bg1a or Potassium channel Bgk toxin is voltage-gated potassium (Kv) channel blocker toxin extracted from sea anemone Bunodosoma granulifera. The present study ...
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Permeation Mechanism of Potassium Ions through the Large Conductance Ca2+-Activated Potassium Channel
... Motivation is an important factor for water molecule to pass through SF. Water molecules are independent of K + s inside SF because K + s are dehydrated inside SF. Under 𝑅𝑅𝐾𝐾 �����⃑ of the Slo1 channel, neutral ...
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The response of the tandem pore potassium channel TASK 3 (K2P9 1) to voltage : gating at the cytoplasmic mouth
... the channel upon excision of the patch, perhaps owing to depletion of PIP 2 (Chemin et ...in 3 patches) and (ii) consistent values were obtained for P open over several minutes of ...
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Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
... Conclusion The KCNQ K + channel blocking drugs, linopirdine and XE991, are potent and powerful constrictors of pulmo- nary arteries. This is a potentially serious side effect of the drugs and should be considered ...
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Investigation of the pharmacophore of BK[ca] potassium channel openers
... Xu et al (2001) define the requirements of an ideal HTS assay that include, sensitivity, specificity, through-put, robustness, information content, flexibility, cost and physiological relevance. Therefore to meet these ...
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Kinetic modeling of ion conduction in KcsA potassium channel
... a potassium channel of known structure that shows both high conduction rates and selectivity among monovalent ...this channel that assumes rapid ion transport within the filter has recently been ...
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Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells
... Fig. 3. Mitochondria-targeted Kv1.3 inhibitors induce cell death of glioma cell lines. (A) GL261, LN308 and A172 cells were treated for 24 hrs with different concentrations of Kv1.3 inhibitors PAP-1 and Psora-4 ...
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Positive Trafficking Pathways of a Voltage Gated Potassium Channel
... 29 2.1. Abstract The Shaker family potassium channel, Kv1.2, is a key determinant of membrane excitability in neurons and cardiovascular tissue. Kv1.2 is subject to multiple forms of regulation and ...
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Calculation of the Gating Charge for the Kv1.2 Voltage-Activated Potassium Channel
... Kv1.2 potassium channel in the active and resting state, originally presented elsewhere, are here refined using molecular dynamics simulations in an explicit membrane-solvent ...the channel determined ...
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The Eag potassium channel as a new prognostic marker in ovarian cancer
... and having a larger cohort may also change the differ- ence between the two markers. Conclusion In summary, we have demonstrated for the first time that Eag and HERG K + channels are overexpressed in ovarian cancer and ...
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Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator
... of potassium, verapamil, calcium-free medium, and antagonists of the KCa channel (charybdotoxin, iberiotoxin) also blocked flow-mediated ...specific potassium channel to induce the release of ...
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The synthesis of ligands for the large conductance calcium activated potassium channel
... the channel causing it to close whereas Mg ADP opens the ...the channel. The channel is opened by drugs such chromakalim, 1 evchromakalim and diazoxide It was observed that the strength o f blocking ...
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Molecular identification of ATP sensitive Mitochondrial Potassium Channel (mitoKATP)
... functional channel is in vitro reconstitution ...a channel i) selective for monovalent cations, ii) blocked by tetraethylammonium chloride (TEA), iii) sensitive to ATP ...
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Glycosylation, Assembly and Trafficking of Cardiac Potassium Channel Complexes: A Dissertation
... Having confirmed the presence of O-glycans on E1 peptides in both CHO cells and native cardiac tissues, we next determined which amino acid residues acquired O- glycans on the E1 N-terminus. The N-terminal sequence of E1 ...
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