Notch ligands
NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma
... of NOTCH ligand JAG2 in MYC-driven Group 3 tumors To date, the distribution and potential role of NOTCH ligands within the defined MB molecular sub-groups is ...examined NOTCH ligands ...
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Blockade of individual Notch ligands and receptors controls graft versus host disease
... identified Notch signaling in T cells as a new therapeutic target for preventing ...GVHD. Notch-deprived T cells showed markedly decreased production of inflammatory cytokines, but normal in vivo ...
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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
... a Notch ligand (either Dll1 +/– , Dll1 +/hyp or Jag2 +/– ) demonstrated no significant increases in hair cell numbers when compared with wild-type embryos, although occasional extra inner and outer hair cells were ...
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DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock
... missing, Notch ligands not only fail to activate Notch, but also accumulate on the cell surface instead of undergoing rapid ...that Notch activation somehow requires that the Notch ...
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Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
... cells. Notch signalling is thought to govern this pattern of differentiation through lateral ...that Notch signalling also has a prior function – inductive rather than inhibitory – in defining the prosensory ...
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The intracellular region of Notch ligands: does the tail make the difference?
... of Notch ligands couples the Notch signal transduction machinery to PDZ containing, membrane associated proteins that play a role in the organization of cell-cell ...
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Fibroblastic niches prime T cell alloimmunity through Delta like Notch ligands
... Our in vivo results contrast with those of past work identifying a role for stromal cells as negative regulators of immune responses (66–68), as the dominant role of these cells after allo-BMT was to promote rather than ...
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Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
... canonical Notch ligands (Dll1, Dll3, Dll4, Jag1 and Jag2) in mammals (Lai, ...Serrate-related ligands by E3 ubiquitin ligases has not been investigated, although it has been shown that Serrate, like ...
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Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development
... What then is the function of the ATEV motif? In this paper we show that it mediates binding to MAGI proteins (MAGUK proteins with inverted domain arrangement) – a subset of the MAGUK (membrane-associated guanylate kinase ...
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Lateral inhibition of Notch signaling in neoplastic cells
... of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral ...of Notch ligands in glioblastoma neurospheres and pancreatic carcinoma cells ...
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Targeting γ-secretase in breast cancer
... that Notch receptors are γ -secretase substrates. Notch receptors are a family of evolutionarily conserved transmembrane proteins and humans have four Notch homologs, ...classical Notch ...
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Literature review of Notch melanoma receptors
... All Notch receptors are synthesized as full-length pro- teins that undergo successive proteolytic cleavages, cul- minating in the release of NICD, which will act on the ...nucleus. Notch ligands ...
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Differential regulation of osteoclastogenesis by Notch2/Delta like 1 and Notch1/Jagged1 axes
... Osteoclasts are known to play a pivotal role in the patho- genesis of bone erosion in RA, and our data indicated that osteoclastogenesis was dominantly supported by Dll1 among Notch ligands. In order to ...
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Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity
... different Notch ligands play in modulating T-cell ...Jagged ligands in the regulation of T-cell-mediated immunity in mouse models of lung and pancreatic tumors and cardiac allograft ...of ...
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Notch signaling represses p63 expression in the developing surface ectoderm
... non-canonical Notch signaling may be involved by interacting with alternative signaling pathways such as FGF, Shh and Wnt signaling (Sanalkumar et ...canonical Notch signaling in the skin occurs given the ...
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The correlation between common 2D femoral notch parameters and 3D notch volume: a retrospective MRI study
... femoral notch parameters were related to ACL injuries in our ...femoral notch inlet, outlet, and ACL attachment were not effective parameters for predicting ACL injuries in the multivariate ...femoral ...
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Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy
... with NOTCH mutations in ...direct Notch target genes described in MCL ...of Notch-target genes ...known Notch-target genes that have been described as a marker of the effect of OMP- 52M51 in ...
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Stress Analysis of Notches Using Numerical Method
... different notch geometries on plate specimen by keeping depth and area ...different notch geometries keeping same depth and area are separately discussed in the following ...
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The expression of Delta ligands in the sponge Amphimedon queenslandica suggests an ancient role for Notch signaling in metazoan development
... multiple ligands may also be to facilitate the activation of reciprocal events in the signaling cell as a result of receptor/ligand ...DSL ligands are divergent and do not contain any globular domains, ...
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Redundancy and cooperation in Notch intercellular signaling
... development, Notch signaling drives spatially coordinated differentiation by establishing communication between adjacent ...equivalent. Notch signaling is commonly activated by several distinct ...
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