notch pathway
The Notch pathway in the developing hematopoietic system
... conditionally-targeted Notch alleles showed that Notch activity is only required for T and B lymphoid differen- tiation in vivo (Radtke et ...of Notch signalling, develop a myelopro- liferative ...
15
NOTCH pathway inactivation promotes bladder cancer progression
... the NOTCH pathway could be oncogenic in bladder cancer (37, 38), there is substantial evidence indicating a tumor-suppressive ...the NOTCH pathway ...of NOTCH muta- tions from bladder ...
8
Notch pathway: a bistable inducer of biological noise?
... that Notch signalling amplifies genetic noise by two parallel ...Simultaneously, Notch signalling increases translation efficiency by stimulat- ing progression of cycling cells into G1 phase [47, 88] char- ...
13
Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells
... of Notch- 1 was significantly higher in PCSCs isolated from LNCaP and PC-3 cell lines, and inhibition of Notch-1 with shRNA could improve chemosensitivity in PCSCs ...of Notch-1 mRNA was ...
8
Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization
... indirect pathway. The NF-κB signalling pathway, which is a classic pathway that promotes the M1 polarization of macrophages, is closely related to the inflammatory response [13, ...of Notch ...
15
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
... the Notch pathway by agents that are foreign to our bodies such as TLR ...of Notch signaling by endogenous factors that are highly involved in immune ...of Notch pathway activation ...
16
A Genetic Screen for Novel Components of the Notch Signaling Pathway During Drosophila Bristle Development
... Figure 1.—The Ax 16 bris- tle phenotype is dominantly suppressed by mutations in the Notch pathway. Scan- ning electron microscopy (SEM) images of bristle phenotypes. (A) Wild-type control, yw. (B) The ...
10
miR-449a regulates insulin signalling by targeting the Notch ligand, Jag1 in skeletal muscle cells
... 1a. Pathway analyses of these common predicted targets using the KEGG database within Enrichr identified Notch signalling pathway as one of the most significantly over-represented pathway ...
10
Mathematical models for the Notch and Wnt signaling pathways and the crosstalk between them during somitogenesis
... the Notch and Wnt pathways in somitogenesis is very compli- ...of Notch pathway and is also a downstream target gene of the Wnt ...Wnt pathway, activate transcription of Dll1 cooperating with ...
20
New Capabilities of the Notch Signaling Pathway
... of Notch signaling requires manipulation of both ligand-expressing sender cells and receiver cells, and the contacts between ...measuring Notch signaling levels and dynamics is the instability of the ...
116
Lateral inhibition of Notch signaling in neoplastic cells
... of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral ...of Notch ligands in glioblastoma neurospheres and pancreatic carcinoma cells cultured in ...
12
Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?
... Herein we identify increased signaling of the Wnt and Notch pathways as potential causes for the renal disease in SIOD. Most SIOD kidneys exhibited increased levels of unphosphorylated β-catenin and NICD ...
12
<p>LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma</p>
... The Notch pathway is involved in various cellular processes such as cell growth and ...the Notch family consists of four Notch recep- tors (Notch1 – 4) and fi ve ligands (Delta-like 1, 3 and 4; ...
11
Ldb1 and Rnf12 dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina
... the Notch signaling ...multiple Notch pathway genes in both the retina (de Melo et ...2013). Notch signaling regulates the maintenance of multipotent RPCs through the downstream activation of ...
10
NOTCH induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells
... intracellular NOTCH domain is cleaved and translo- cates to the nucleus, where it regulates downstream target gene transcription ...The NOTCH link to cancer was first reported in human T cell leukemia, in ...
14
Notch signaling in the development of the inner ear
... the Notch cell-cell signaling pathway, first characterized in Drosophila and crucial for bristle development, also has a key role in controlling the pattern of sensory hair cells and supporting cells in the ...
199
RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer
... canonical Notch signalling does not influence the formation of Hh- dependent medulloblastoma (Figures 3H,L, 4, and 5D,H,L, ...of Notch pathway com- ponents in both human and murine medulloblastoma, ...
13
HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways
... the Notch pathway, inhibited ac- tivation of the Notch pathway and reversed resistance to PTX, anti-apoptosis and high expression of cancer stem cell markers induced by HIF-2α ...the ...
14
Notch signaling deregulation in multiple myeloma: A rational molecular target
... reported, Notch signaling alterations described in MM result in an increased expression of Notch pathway members including receptors and ligands ...of Notch signaling in comparison to ...
15
Association between Notch signaling pathway and cancer
... This pathway also regulates the development and differentiation of multiple hematopoietic cell types, including T and B cells, monocytes, macrophages, dendritic cells, osteoclasts and natural killer cells ...of ...
11