NPM1 Mutation
Seibl, Marlene (2011): Quantifizierung von minimaler Resterkrankung bei akuter myeloischer Leukämie mit NPM1 Mutation mittels Real-Time-PCR. Dissertation, LMU München: Medizinische Fakultät
... von NPM1 A, das heißt ähnlich hohe NPM1 A zu ABL1 Ratios, wie eine 1:10 Verdünnung der OCI/AML3 cDNA in ...die NPM1 A Expression in Patienten-cDNA zur Erstdiagnose höher als nach Therapiebeginn, ...
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Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation
... In addition to these mutations, recent reports under- lined the importance of histone genes themselves in can- cer onset. For example, the major histone cluster 1 (HIST1), encoding the vast majority of the redundant core ...
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The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b
... MicroRNAs (miRNAs) are a class of small noncoding RNAs that negatively regulate gene expression at posttranscriptional levels [15]. Aberrant miRNA expression correlates with specific cytogenetic and clinical prognosis ...
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NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome
... particular NPM1 transcripts were highly correlated with each other indicates com- mon transcriptional ...of NPM1 tran- ...particular NPM1 splice variants between the studied ...of NPM1 may ...
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Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations
... FLT3-ITD/TKD mutation rate, and higher IDH2 mutation rate when combined with NPM1 mutation, but little difference in prognoses compared with NPM1 wild ...DNMT3A mutation and was ...
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A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13)
... We described the first case of acute monoblastic leukemia with gain of i(5)(p10), tetrasomy 8, an unbalanced trans- location der(19)t(17;19)(q23;p13.3) and NPM1 mutation.. During the fol[r] ...
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INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia
... gene NPM1, and the most common mutation is referred to as the type A mutation (NPM1-mA) with a 4-base-pair TCTG inser- tion at nucleotide position 960 [7, ...characteristics, NPM1- ...
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MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
... the NPM1 mutation type A ...in NPM1+ CN-AML (Figure 1C) also in the absence of normalization with a reference ...in NPM1+ cases was not influenced by FLT3-ITD status ...
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<p>Strategies for minimal residual disease detection: current perspectives</p>
... Postinduction minimal residual disease predicts outcome and benefit from allogeneic stem cell transplantation in acute myeloid leukemia with NPM1 mutation: a study by the acute leukem[r] ...
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Evaluation of Minimal Residual Disease in Acute Myeloid Leukemia with NPM1 Marker
... NPM1 mutation is more specific, sensitive and stable molecular marker in comparison with the above mentioned ...with NPM1 mutant was higher than that in AML-NK patients without NPM1 ...1 ...
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NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
... frameshift mutation occurs in NPM1 at its nucleolar localization motif, a redundant which will lead to nuclearcytoplasm shuttling to result in development of a special type of AML [7, ...that NPM1 ...
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Molecules that target nucleophosmin for cancer treatment: an update
... with NPM1 in vivo ...the NPM1-avrainvillamide complex was disrupted by iodoacetamide ...binds NPM1 primarily by alkylating Cys275, which is located in helix H2 of the C-terminal three-helix bundle ...
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Original Article Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation
... Point mutation at exon 12 of the NPM1 gene represents one of the most frequent mutations in adult AML, in approximately 30% of unse- lected AML cases ...[20]. NPM1 mutation is usu- ally ...
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<p>Acute myeloid leukemia patient with <em>FLT3-ITD</em> and <em>NPM1</em> double mutation should undergo allogeneic hematopoietic stem cell transplantation in CR1 for better prognosis </p>
... FLT3 mutation, internal tandem duplication of FLT3 (FLT3-ITD) and tyrosine kinase domain of FLT3 ...FLT3-ITD mutation with normal cytogenetics has a poor risk prognosis. NPM1 is a gene for expression ...
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A Case Report of Concurrent IDH1 and NPM1 Mutations in a Novel t(X;2)(q28;p22) Translocation in Acute Myeloid Leukaemia without Maturation (AML-M1)
... the NPM1 mutation during clonal evolution ...with NPM1 and IDH1 ...the NPM1 with IDH1 mutations in AML, the patient passed away on day 9 ...
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Genomic Classification and Prognosis in Acute Myeloid Leukemia.
... TP53 mutation and complex karyotype (TP53 mutation, 17 patients; complex karyotype, 89; and TP53 mutation with complex karyotype, ...(ASXL1 mutation, 55 patients; SRSF2 mutation, 74; ...
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Acute Myeloid Leukemia—Genetic Alterations and Their Clinical Prognosis
... ARF. NPM1 actually functions as histone chaperone that is capable of histone assembly, nucleosome assembly and increasing acetylation-dependent transcription 38,39 ...
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
... and NPM1, which localizes to the ...for NPM1 and NCL closely adjacent to the circum- ference of the BiFC signal ...of NPM1 and NCL, from being diffuse throughout the nucleolus in untreated cells to ...
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Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer
... to NPM1 potently affecting in vitro and in vivo tumor cell growth of various tumor types as well as ...Furthermore, NPM1 binds to androgen receptor (AR) and modulate its ...the NPM1 and its Thr199 ...
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Mitogen-activated protein kinase binding protein 1 ( MAPKBP1 is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia
... Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) between 1990 and 2008 (available at http:// www.hovon.nl). The details of therapeutic protocol were shown in supplementary Figure 4[48]. One hundred thirty patients ...
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