Nrf2–Keap1 signaling pathway
Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
... stimulated Nrf2-knockdown RAECs (Figure ...an Nrf2-dependent mecha- ...activates Nrf2 signaling and the binding target of SchB. In general, Nrf2 exists in the cytoplasm by binding with ...
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Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
... the Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many cytoprotective and detoxifying enzymes, thus playing a pivotal role in ...
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<p>Desflurane Preconditioning Protects Against Renal Ischemia–Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway</p>
... Methods: Renal I/R injury rats model was constructed, and the expressions of serum renal function parameters (blood urea nitrogen (BUN) and serum creatinine (SCr)) and lipid peroxida- tion-related factors were detected ...
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Original Article Study of the regulation and mechanism of SOX9 on podocytes in diabetic nephropathy by regulation of Nrf2-Keap1-ARE signaling pathway
... Mouse podocyte MCP-1 cells were preserved by the laboratory and stored in liquid nitrogen. DMEM-F12 medium and penicillin-streptomy- cin were purchased from Hyclone, USA. Dime- thyl sulfoxide (DMSO), fetal bovine serum ...
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Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
... the Keap1-Nrf2 pathway is an emerging target for PC prevention and ...Indeed, Nrf2 plays an either tumor-suppressive or promoting function in PC, which depends on the developmental stages of ...
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Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
... several Nrf2 target genes involved in the anti- oxidant defense system (SOD1, GPX1, TXNR1, HO-1) and phase II metabolism (NQO1, MGST1, ...conditions, Nrf2 is located in the cytosol of cells where it is ...
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Original Article IL-17 enhances oxidative stress in hepatocytes through Nrf2/keap1 signal pathway activation
... diverse human liver diseases, including alco- holic liver disease, acute liver injury and chronic hepatitis B and C, primary biliary cirrhosis, hep- ato-cellular carcinoma and acute liver trans- plant rejection [12]. But ...
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Acrolein exposure suppresses antigen-induced pulmonary inflammation
... the Nrf2 pathway through direct interaction with redox-sensing cysteine residues within its inhibitor Keap1 ...of Keap1, accumulation of Nrf2 protein, and in- duction of the ...
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Original Article MiR-7 involves the activation of Nrf2 pathway by targeting Keap1 in epileptic seizure
... Molecular signaling pathways that involves in epilepsy pathogenesis identify new therapeutic targets or biomarkers of intractable ...Moreover, Nrf2 and its two prominent transcriptional targets (HO-1 and ...
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Original Article Phenethyl isothiocyanate potentiates anti-tumor effects of cisplatin through Nrf2/keap1 signaling pathways
... 35]. Nrf2, nuclear factor erythroid-2 related factor 2, is the key signaling protein within the ...genes. Keap1, Kelch ECH associating protein 1, is a very cysteine- rich protein [36] that regulates ...
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Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1
... NFκB-p65 pathway in ...B pathway or interferes with its transcriptional activ- ity [48, ...B signaling pathway, we might suppose that the transcrip- tion of genes controlled by these ...
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GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
... and signaling aberra- tions, cancer cells generally have elevated levels of reactive oxygen species (ROS), which are balanced by an increased antioxidant capacity ...response. NRF2 induces tumori- genesis, ...
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A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
... Cell Signaling Technology (Danvers, MA, USA); mouse monoclonal antibody against anti-β actin from Abcam (Cambridge, UK); rabbit anti-Nrf2 (H-300) polyclonal antibody, rhodamine-conjugated goat anti-mouse ...
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Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary
... phate buffered saline (PBS) at room temperature for 1 h, the membranes were blotted overnight at 4 °C with primary antibodies, including anti-Nrf2 (1:100; 16,396–1-AP, Pro- teintech Group, Illinois, USA), ...
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Original Article Expression patterns and prognostic values of Nrf2 and Keap1 in nasopharyngeal carcinoma
... (Keap1) signaling pathway is abnormally activated in response to cellular stress in various types of human ...nuclear Nrf2 and cytoplasmic Keap1 in 108 nasopharyn- geal carcinoma (NPC) ...
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Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... The Nrf2-Keap1-ARE signaling system is central to the induction of phase 2 genes by electrophiles and antioxi- dants ...vate Nrf2 and translocated into the nucleus, with increased expression ...
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Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1 Nrf2 oxidative defence pathway
... The roles of and spatiotemporal relationships between the receptors that regulate selective autophagy is still unclear. Here we show 26S proteasome dysfunction in cortical neurons is associated with increased ...
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Coal tar induces AHR dependent skin barrier repair in atopic dermatitis
... Coal tar normalizes histopathological and molecular hallmarks of AD in skin equivalents. Th2 cytokines like IL-4 and IL-13 induce spongiosis and apoptosis in skin equivalents, probably via STAT6 signaling (18). ...
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The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes
... treatment with derivatives S2 and S5. The same effect was observed for GSTP in the case of compound S2. Resveratrol and its derivatives reduced the NQO2 protein level in HaCaT cells. Thus, it is possible that increased ...
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Original Article Lycopene attenuates LPS-induced liver injury by inactivation of NF-κB/COX-2 signaling
... vated Nrf2 translocates into the nucleus, and modulates expression of antioxidant-related genes at transcriptional level ...[65]. Nrf2 plays a vital role in antioxidant defense systems by reducing ...
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