Nrf2 signaling
Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood–brain barrier following hypoxia-reoxygenation stress
... of signaling pathways involved in Mrp regulation in the setting of H/R will enable development of pharmacological approaches to target Mrp-mediated efflux ...is signaling mediated by Nrf2, a sensor ...
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Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide
... activates Nrf2 signaling in neuronal cells The effect of 4-octyl itaconate (OI) on Nrf2 signaling was ...known Nrf2-dependent genes, including HO1, NQO1 and GCLC ...Although Nrf2 ...
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Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing
... of Nrf2 signaling pathway which controls cellular ...for NRF2, HMOX1 and NQO1 were performed with total RNAs isolated from the wound ...of Nrf2, HO-1 and Nqo1 was determined using Western blot ...
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The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
... The Nrf2 cell signaling pathway has been demonstrated to contribute to the regulation of a wide variety of antioxi- dant, detoxification, and cell survival ...conditions, Nrf2 activation plays a ...
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Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
... [19]. Nrf2 pathway is regarded as the most important pathway in the cell to protect cells against oxidative stress ...of Nrf2 activity represents a critical step in initiating a cellular antioxidant ...
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Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner
... activate Nrf2 signaling pathway in mice midbrain SN, the expression of Nrf2, Keap1, HO-1, and NQO1 were detected by RT-PCR and western blot ...2a, Nrf2 mRNA ex- pression was upregulated in ...
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<p>Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling</p>
... Moreover, Nrf2/ARE pathway was found to inhibit ROS-induced NLRP3 in fl ammasome activation in BV2 ...affects Nrf2 signaling in AP remains ...via Nrf2 signaling. To further con fi rm this ...
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Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
... NRF2 signaling and sensitized A549 and H460 cells to platinum-based ...of NRF2 downstream genes at the mRNA and pro- tein levels and resulted in increased cell survival after exposure to ...
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Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
... Indeed, Nrf2 plays an either tumor-suppressive or promoting function in PC, which depends on the developmental stages of the disease and the cellular ...natural-product Nrf2 activators have been developed ...
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Original Article Fibroblast growth factor 21 attenuates inflammation and oxidative stress in atherosclerotic rat via enhancing the Nrf1-ARE signaling pathway
... the Nrf2-signaling pathway was involved in FGF21- mediated ...and Nrf2-signaling related protein were measured in the serum or/and arterial tissues of ...and Nrf2-ARE signaling ...
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Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
... in Nrf2 signaling pathway by using 2 types of cells; mouse embryonic fibroblasts (MEFs) derived from wild-type (WT) and Nrf2 knockout (N0) ...
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Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification
... activate Nrf2 signaling pathway to induce PDAC cellular ...increased Nrf2 nuclear activity and induced transcription of genes involved in ROS detoxification and pentose phosphate ...that Nrf2 ...
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<p>Identification of Pannexin 2 as a Novel Marker Correlating with Ferroptosis and Malignant Phenotypes of Prostate Cancer Cells</p>
... by Nrf2 activator, oltipraz. The Nrf2 signaling pathway was consequently applied to determine underlying mechanism of PANX2 in PCa ...of Nrf2 signaling pathway (Nrf2, HO-1, and ...
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Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
... of Nrf2 is the kelch-like ECH-associated protein (Keap1), which serves as a substrate adapter protein within the RBX1 E3 ubiquitin ligase complex (CRL Keap1 ) ...to Nrf2 thereby preventing Nrf2 from ...
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Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment
... Notably, recent investigations indicate the importance of transcriptional factors for regulating constitutive acti- vation of autophagy [53, 54]. Pancreatic adenocarcinoma cells exhibit constitutive nuclear expression of ...
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Upregulation of CKIP-1 inhibits high-glucose induced inflammation and oxidative stress in HRECs and attenuates diabetic retinopathy by modulating Nrf2/ARE signaling pathway: an in vitro study
... and Nrf2/ARE signaling pathway in DR ...down Nrf2 in HRECs (Fig. 5c). In addition to cell viability, CKIP-1 and Nrf2 also have similar effects on oxidative stress, inflam- mation and cell ...
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CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs
... whether Nrf2 binding to the Prdx2 promoter sites has functional consequences, an 869-bp region from the Prdx2 promoter that includes the cARE, eARE, and eARE-like sites (P6; Figure 4B), as well as truncated ...
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Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression
... an Nrf2-expressing vector for 24 h prior to assaying for luciferase ...expressing Nrf2, KAP1, and LANA-1 ...between Nrf2 and KAP1 at various times of ...the Nrf2, LANA-1, and KAP1 complex on ...
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Original Article Phenethyl isothiocyanate potentiates anti-tumor effects of cisplatin through Nrf2/keap1 signaling pathways
... 35]. Nrf2, nuclear factor erythroid-2 related factor 2, is the key signaling protein within the ...regulates Nrf2 activity by binding and consequently mediating its polyu- biquitination and ...
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Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets
... state, Nrf2 is sequestered by Keap1 and targeted for rapid ubiquitin-mediated degradation [21-24, 36, ...stress, Nrf2 is released from Keap1 and phosphorylated, allowing Nrf2 to translocate to the ...
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