nuclear erythroid-related factor 2
Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... Total RNA from cultured cells was prepared as de- scribed above according to the manufacturer’ s instruc- tions. Total RNA was reverse transcribed into cDNA using TransScript First-Strand cDNA Synthesis Super- Mix ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... all cell types and tissues, and is most abundant in tissues where detoxification reactions occur routinely, including the lungs. However, Nrf2 is also inducible and triggered by oxidative stress, injury, and ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... Here, we investigated the effects of clinically used Nrf2 activators on renal functions both in vitro and in vivo. To assess the in-vitro functions, human renal mesangial cells (HRMCs) were used. Mesangial cells ...
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Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... system; 2) the permeability of the blood–brain barrier; and 3) the central nervous ...the nuclear factor (erythroid- derived 2)-related factor 2 pathway of cell ...
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
... Adoptive transfer of Ad-HO-1 BMMs induced Akt activation and enhanced antiapoptotic gene expression in Nrf2- deficient livers, accompanied by de- creased frequency of apoptotic cells. In marked contrast, Nrf2 deficiency ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... Abstract: Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2– related factor 2 (Nrf2), a member of the “cap’n’collar” family of basic region–leucine zipper transcription factors, which has previously ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and synthesis of heme oxygenase (HO-1), as well as to mitigate lipopolysaccharide (LPS)-induced nitric oxide ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of postmortem ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... transcription factor also found as HB in the NCPI, ubiquitously expressed in organs ...processes related to nickel-induced toxicity [102], and other biological pro- cesses such as the cell cycle, apoptosis, ...
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Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...subsequent nuclear ...
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Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... counterstaining was performed with 4′,6- diamidino-2′-phenylindole dihydrochloride (DAPI). Finally, the stained sections were examined under fluorescence microscope by a researcher who was blinded to the ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... decreased nuclear Nrf2 accu- mulation might be attributed to other involved pathways and impaired nuclear export caused by heat ...transcription factor (Figure ...
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The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... From these statements it can be concluded that administration of nimodipine can decrease Nrf2 expression in SH-SY5Y neuron cell culture due to activation. the transcription factor Nrf2 itself is directly ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... relapsing-remitting MS who manifest current disease activity by either clinical symptoms or recent lesions on magnetic resonance imaging (MRI) should be offered treatment with disease-modifying therapy. Certain ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... This clustering analysis suggests that different skin care needs depend on the naturally occurring single genetic vari- ants present in each one of the genetic clusters. For example, cluster 8 shows the worst combination ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... PQ produces lung oxidative stress in animals [2] and humans [3]. Excessive levels of ROS damage cellular mac- romolecules, such as DNA, lipids and proteins, leading to oxidative stress-induced tissue injury [45]. ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...of nuclear factor ...
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