Nuclear factor-2-erythroid 2-related factor 2
Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... counterstaining was performed with 4′,6- diamidino-2′-phenylindole dihydrochloride (DAPI). Finally, the stained sections were examined under fluorescence microscope by a researcher who was blinded to the ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... Caspase-3/7 reagent coupled the activated caspase-3/7 recognition motif (DEVD) to NucView™488, a DNA inter- calating dye. When added to tissue culture medium, this inert, non-fluorescent substrate crosses the cell ...
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Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... system; 2) the permeability of the blood–brain barrier; and 3) the central nervous ...the nuclear factor (erythroid- derived 2)-related factor 2 pathway of cell ...
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The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... When finished, remove the supernatant until the remaining pellets. Add 2 ml medium into the pellet and do pipetting to homogenize. Insert the media that has been made into 2 new flasks of 5 ml each and put ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... This clustering analysis suggests that different skin care needs depend on the naturally occurring single genetic vari- ants present in each one of the genetic clusters. For example, cluster 8 shows the worst combination ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... transcription factor also found as HB in the NCPI, ubiquitously expressed in organs ...processes related to nickel-induced toxicity [102], and other biological pro- cesses such as the cell cycle, apoptosis, ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2– related factor 2 (Nrf2), a member of the “cap’n’collar” family of basic region–leucine zipper transcription factors, which has previously ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and synthesis of heme oxygenase (HO-1), as well as to mitigate lipopolysaccharide (LPS)-induced nitric oxide ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Antigen retrieval was carried out by steaming (20 minutes at 80˚C) in citrate buffer at pH 6.0. The following primary antibodies were used: a polyclonal an- ti-Nrf-2 antibody (Santa Cruz Biotechnology, CA, USA), ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... of 2 –△△ Ct (△Ct represents the difference of threshold cycle value between the target gene and the inner control; △△Ct rep- resents the difference of △Ct between different groups) was used to analyze the ...
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Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... Most mammal testes suspend in a scrotum outside the body cavity and are more susceptible to heat than other organs [2,16]. Scrotal temperature above the normal range can disrupt spermatogenesis and increase rates of sub ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... Abstract: Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...of nuclear factor ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... There are no histopathological studies on fibrosis of the kidney in pristane-induced LN. In the present study, the upregulation of TGF-β1 expression in the kidney of pristane-injected mice was detected at the ...
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Changes in Monocyte Chemoattractive Protein, Nuclear Respiratory Factor 2, B-Cell Leukemia/Lymphoma 2 and Cholinesterase in Serum of Autistic Children
... the nuclear factor erythroid 2-related factor 2 ...transcription factor Nrf2 regulates cellular resistance to oxidants via controlling the expression of antioxidant ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...subsequent nuclear ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... Abstract: Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by the demyelination of neuronal axons. Four different patterns of demyelination have been described, showing the ...
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
... growth factor (TGF)-β (Fig- ure 3B, p < ...necrosis factor (TNF)-α, IL-1β, monocyte chemoattractant protein (MCP)-1 and C-X-C motif chemokine 10 (CXCL10) ex- pression (Figure 3C, p < ...
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