nuclear factor erythroid-2
Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... Background: Nickel and nickel-containing compounds (NCC) are known human carcinogens. However, the precise molecular mechanisms of nickel-induced malignant transformation remain unknown. Proposed mechanisms suggest that ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor 2; nRNP, nuclear ribonucleoprotein; PAS, ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... Abstract: Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by the demyelination of neuronal axons. Four different patterns of demyelination have been described, showing the ...
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Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the most important endogenous protective factors against oxidative ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... Nuclear factor erythroid 2-related factor 2 (Nrf2), also known as NFE2L2, is ubiquitously expressed at high concentrations in various human organs including the ...transcription ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Glioblastoma is the most common primary malignant brain tumor, comprising 16% of all primary brain and central nervous system neoplasms [5]. Although glioblastomas occur almost exclusively in the brain, they can also ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... In most mammals, the testes normally complete descent into a scrotum before birth to provide a lower temperature for spermatogenesis [1]. If descent does not occur and testis remains in abdomen, it’s de- scribed as the ...
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The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... From these statements it can be concluded that administration of nimodipine can decrease Nrf2 expression in SH-SY5Y neuron cell culture due to activation. the transcription factor Nrf2 itself is directly ...
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Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... Green tea, which is a rich source of the immunomodula- tory polyphenol (−)-Epigallocatechin-3-gallate (EGCG), is one of the most commonly consumed beverages in the world. EGCG has been shown to have antioxidant and ...
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
... Adoptive transfer of Ad-HO-1 BMMs induced Akt activation and enhanced antiapoptotic gene expression in Nrf2- deficient livers, accompanied by de- creased frequency of apoptotic cells. In marked contrast, Nrf2 deficiency ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and synthesis of heme oxygenase (HO-1), as well as to mitigate lipopolysaccharide (LPS)-induced nitric oxide (NO), ...
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Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase 1), ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...subsequent nuclear ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...of nuclear factor ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... This clustering analysis suggests that different skin care needs depend on the naturally occurring single genetic vari- ants present in each one of the genetic clusters. For example, cluster 8 shows the worst combination ...
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NRF2 and p53: Januses in cancer?
... transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... Abstract: Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, ...
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Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... system; 2) the permeability of the blood–brain barrier; and 3) the central nervous ...the nuclear factor (erythroid- derived 2)-related factor 2 pathway of cell defense as ...
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