Nuclear factor erythroid 2-like
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... Of note, activation of Nrf2 in T cells by tert - butylhydroquinone (tBHQ), inhibits production of the Th1 cytokine, IFN-γ [56]. Maicas et al. reported that deficiency of Nrf2 resulted in increased migration of ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective ...(Kelch- like ECH-associated protein 1), and together they are ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... growth factor- β 1 (TGF- β 1), connective tissue growth factor (CTGF), collagen-1 and collagen III were measured by real-time ...(HO-1), nuclear factor erythroid 2p45-related ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor 2; nRNP, nuclear ribonucleoprotein; PAS, ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...Kelch- like ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... tially clustered in association with proteins involved with the negative regulation of transcription and gene expres- sion. Several studies have also demonstrated that nickel species are also capable of negatively ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... radicals like hydroxyl, superoxide, alkoxyl, peroxyl, glutathiyl, tocopheroxyl, hydroperoxyl and ...diseases. Nuclear factor erythroid-2-related factor 2 is a master ...
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NRF2 and p53: Januses in cancer?
... transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of postmortem ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... The C57BL/6J mice were obtained from the Experimental Animal Center at the Fourth Military Medical University, Xi’an, China. The animals were housed at 21 ± 2°C, 12 h light/ dark cycle, and 60-70% humidity with ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... We examined the protein expression and subcellular location of Nrf2 in colonic tissue during the exposure of mice to DSS. The Western blot analysis results in Figure 6A show a sig- nificant increase of Nrf2 protein ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... cluster 2, mainly because of the differential con- tribution of SNPs rs6721961 (46% versus 100%), rs1050450 (35% versus 76%), rs1001179 (18% versus 76%), rs1800795 ...
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Inhibitory effect of phytol on cellular senescence
... The transcription factor NRF2 coordinates cellular defenses against oxidative stress by inducing antioxidant genes. Under non-stressed conditions, NRF2 exists in an inactive cytoplasmic form bound to KEAP1, an ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... 4-HHE is more potent than 4-HNE in stimulation of HO-1 (Fig. 5d). This latter observation is in line with a re- port showing higher electrophilic activity for 4-HHE as compared to 4-HNE [6]. Taken together, results from ...
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Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways
... Thus, what are the relevant inflammatory pathways as- sociated with Nrf2? Among the various inflammatory pathways, NOD-like receptor protein 3 (NLRP3) inflam- masome and nuclear factor kappa B ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... that 2-day consecutive heat stress induced Nrf2 accumulation in the nuclei of Leydig cells and germ ...strong nuclear Nrf2 ac- cumulation exists in mouse ...creased nuclear Nrf2 accumulation on day ...
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Human colony forming units erythroid do not require accessory cells, but do require direct interaction with insulin like growth factor I and/or insulin for erythroid development
... heterogeneous erythroid progenitor cells, contaminant cells, or serum may alter erythroid colony development in ...units- erythroid (CFU-E), we cultured partially purified human blood burst-forming ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... Total RNA from cultured cells was prepared as de- scribed above according to the manufacturer’ s instruc- tions. Total RNA was reverse transcribed into cDNA using TransScript First-Strand cDNA Synthesis Super- Mix ...
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Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
... AMLs with CEBPA mutations show many characteris- tics also found in the EKLF-positive AML group, such as a high percentage of erythroblasts and favorable out- come. Although the study population was small, we found that ...
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