nuclear factor erythroid 2-like 1
An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... radicals like hydroxyl, superoxide, alkoxyl, peroxyl, glutathiyl, tocopheroxyl, hydroperoxyl and ...diseases. Nuclear factor erythroid-2-related factor 2 is a master ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of ...
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Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... Conventional therapies such as non-steroidal anti-in- flammatory drugs (NSAIDs) and disease modifying anti- rheumatic drugs (DMARDs) along with biologics and other experimental treatments have been used to slow the ...
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Anti TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
... colony-stimulating factor; HO-1: heme oxygenase 1; HRP: horse radish peroxidase; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; IL: interleukin; LPS: lipopolysaccharide; mRNA: messenger RNA; NADPH: ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... Paraquat, (PQ) widely used as an herbicide, is controver- sial because of the high mortality of PQ exposure, with a typical case fatality of 50 – 90 % [1]. The major cause of death by PQ poisoning is respiratory ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... cluster 1 several class I HDAC (HDAC1, HDAC2, HDAC3) were identified, together with proteins with histone deacetylase activity like NCoR-1 and ...Ni 2+ inhibits HAT activity via ROS production ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... protein 1; LN, lupus nephritis; LPS, lipopolysaccharide; LUNAR, Lupus Nephritis Assessment with Rituximab; mAb, monoclonal antibody; MCP-1, monocyte chemoattractant protein-1; MMF, monomethyl ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective ...(Kelch- like ECH-associated protein 1), and together ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...Kelch- like ...
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Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis
... Reduction–oxidation (redox) balance is particularly im- portant in the airways because they represent the first contact with environmental oxidants. Generation of ROS has been implicated in the pathogenesis of many acute ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... in 1 mL of solution A (250 mM sucrose; 1.5 mM MgCl 2 ; 20 mM HEPES; 10 mM KCl; 1 mM ethylenediaminetetraacetic acid (EDTA), pH ...8.0; 1 mM ethylene glycol tetraacetic acid; and 1 × ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... for 2 h was chosen according to previous reports ...Figure 1, individual scrotal surface temperature was defined as the average value of whole testis surface temperature and individual body surface ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... Studies so far have indicated anti-inflammatory and anti-oxidative effects of 4-HHE and 4-HNE added exogen- ously to microglial cells. Since these two alkenals are derived from two different PUFA with opposing functions, ...
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Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways
... and nuclear factor kappa B (NF-κB) pathways play an important role [14, ...caspase 1 protein complex, resulting in the release of IL-1β [17, ...
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NRF2 and p53: Januses in cancer?
... The tumor suppressor activity of p53 is well documented [82, 129-132]. This activity is achieved by the employment of different pathways, spanning from gene and microRNA regulation to protein-protein interaction [130, ...
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Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche
... Fig. 5. Analysis of the pEKLF/GFP mouse. (A) Schematic of the modified expression system (based on Kyba et al., 2002) after its unidirectional, single-copy integration into the single endogenous modified HPRT locus. The ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... Nuclear factor erythroid 2-related factor 2 (Nrf2), also known as NFE2L2, is ubiquitously expressed at high concentrations in various human organs including the ...transcription ...
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Nuclear Klf4 accumulation is associated with cetuximab drug resistance and predicts poor prognosis of nasopharyngeal carcinoma
... After deparaffinization and rehydration, the paraffin- embedded sections were subjected to antigen retrieval for 2 min. Then, the slides were incubated overnight at 4 °C with the following primary antibodies: ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... The majority of IGF-1 is synthesized in the liver under the influence of growth hormone, which is a major pro- moter of postnatal growth [18]. However, deletion of liver specific IGF-1 gene in mice showed ...
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