nuclear factor, erythroid 2-like 2
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... Of note, activation of Nrf2 in T cells by tert - butylhydroquinone (tBHQ), inhibits production of the Th1 cytokine, IFN-γ [56]. Maicas et al. reported that deficiency of Nrf2 resulted in increased migration of ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective ...(Kelch- like ECH-associated protein 1), and together they are ...
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Anti TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
... CZP. Nuclear translocation of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) was evaluated by wide-field microscopy and cell ...H 2 DCFDA fluorescent ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor 2; nRNP, nuclear ribonucleoprotein; PAS, ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of postmortem ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...Kelch- like ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... For RNA isolation, lung tissues were frozen in liquid nitro- gen and stored in a −80 °C freezer until use. Total RNA was extracted from frozen lung tissue (left lung) with TRI- zol reagent and amplified with a PCR ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... tially clustered in association with proteins involved with the negative regulation of transcription and gene expres- sion. Several studies have also demonstrated that nickel species are also capable of negatively ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... radicals like hydroxyl, superoxide, alkoxyl, peroxyl, glutathiyl, tocopheroxyl, hydroperoxyl and ...diseases. Nuclear factor erythroid-2-related factor 2 is a master ...
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NRF2 and p53: Januses in cancer?
... transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... cluster 2, mainly because of the differential con- tribution of SNPs rs6721961 (46% versus 100%), rs1050450 (35% versus 76%), rs1001179 (18% versus 76%), rs1800795 ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... The C57BL/6J mice were obtained from the Experimental Animal Center at the Fourth Military Medical University, Xi’an, China. The animals were housed at 21 ± 2°C, 12 h light/ dark cycle, and 60-70% humidity with ...
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Inhibitory effect of phytol on cellular senescence
... The transcription factor NRF2 coordinates cellular defenses against oxidative stress by inducing antioxidant genes. Under non-stressed conditions, NRF2 exists in an inactive cytoplasmic form bound to KEAP1, an ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... Similar to results of our studies, Lu et al. demonstrated ability for DHA to suppress IFNγ-induced inflammatory re- sponses (TNFα, IL-6, NO, and COX-2), as well as increases in HO-1 levels in BV-2 ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... In most mammals, the testes normally complete descent into a scrotum before birth to provide a lower temperature for spermatogenesis [1]. If descent does not occur and testis remains in abdomen, it’s de- scribed as the ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... MgCl 2 ; 20 mM HEPES; 10 mM KCl; 1 mM ethylenediaminetetraacetic acid (EDTA), pH ...MgCl 2 ; ...the nuclear fraction and was isolated and kept at - 80 ° C until ...
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Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways
... Thus, what are the relevant inflammatory pathways as- sociated with Nrf2? Among the various inflammatory pathways, NOD-like receptor protein 3 (NLRP3) inflam- masome and nuclear factor kappa B ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... lines, 2 hour incubation with IMC-A12 completely blocked downstream signalling of IGF-1R as shown by the suppression of phosphorylated AKT and phosphorylated S6 kinase ...
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Nuclear Klf4 accumulation is associated with cetuximab drug resistance and predicts poor prognosis of nasopharyngeal carcinoma
... the nuclear and cytoplasmic proteins were extracted, respectively, for detection by Western ...of nuclear and cytoplas- mic proteins of 5–8F and HONE1 cells in nasopharyn- geal ...
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