nuclear factor-erythroid 2 (NF-E2)-related factor 2
Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... Abstract: Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by the demyelination of neuronal axons. Four different patterns of demyelination have been described, showing the ...
8
Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... fumarate; NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor 2; nRNP, nuclear ...
12
Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... Background: Nickel and nickel-containing compounds (NCC) are known human carcinogens. However, the precise molecular mechanisms of nickel-induced malignant transformation remain unknown. Proposed mechanisms suggest that ...
13
Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... Nuclear factor erythroid 2-related factor 2 (Nrf2), also known as NFE2L2, is ubiquitously expressed at high concentrations in various human organs including the ...
10
Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the most important endogenous protective factors against oxidative ...
6
Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Antigen retrieval was carried out by steaming (20 minutes at 80˚C) in citrate buffer at pH 6.0. The following primary antibodies were used: a polyclonal an- ti-Nrf-2 antibody (Santa Cruz Biotechnology, CA, USA), ...
6
The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... When finished, remove the supernatant until the remaining pellets. Add 2 ml medium into the pellet and do pipetting to homogenize. Insert the media that has been made into 2 new flasks of 5 ml each and put ...
7
Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... decreased nuclear Nrf2 accu- mulation might be attributed to other involved pathways and impaired nuclear export caused by heat ...transcription factor (Figure ...
10
Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of ...
5
An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...of nuclear factor ...
9
Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
10
Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...subsequent nuclear ...
8
Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase ...
9
Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... fumarate, nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), laquinimod, and teriflunomide linked to MS, experimental autoimmune encephalomyelitis (EAE), immune ...
14
Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... Abstract: Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, ...
12
Polygonum viviparum L induces vasorelaxation in the rat thoracic aorta via activation of nitric oxide synthase in endothelial cells
... The nuclear factor E2-related factor 2 (Nrf2) play a critical role by interacting with cognate DNA-binding domains in the HO-1 pro- moter to up-regulate ho-1 gene transcription ...
9
NRF2 and p53: Januses in cancer?
... It is becoming more evident that, at the functional level, p53 and NRF2 play similar roles and are both providing cells with enhanced capacity to mitigate oxidative stress. Interestingly, recent findings from the Zhang ...
12
12/15 lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function
... 12/15-LO–derived phospholipid oxidation products attenuate DC maturation. 12/15-LO catalyses oxidation of free fatty acids or of fatty acids esterified to phospholipids (11). To identify the 12/15-LO enzymatic products ...
12
Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats
... To investigate the changes in the antioxidant system in rats treated with NTG, we analyzed Nrf2 expression in the nuclear and total cell fractions of TNC from rat models (Fig. 1). The subcutaneous administration ...
9
Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways
... and nuclear factor kappa B (NF-κB) pathways play an important role [14, ...15]. NF-κB can be a sensor to start the inflammatory response under some stimuli, such as ROS, FFA, and ...
15