nuclear factor (erythroid-derived 2) - like 2
Anti TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
... colony-stimulating factor; HO-1: heme oxygenase 1; HRP: horse radish peroxidase; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; IL: interleukin; LPS: lipopolysaccharide; mRNA: messenger RNA; NADPH: nicotinamide ...
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NRF2 and p53: Januses in cancer?
... transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and ...
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Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... (CFA), shares a number of relevant features with human RA. By evaluating the molecular and cellular effects of green tea polyphenols or EGCG in different autoimmune models, these studies have brought to the forefront the ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed ...increased nuclear staining of Nr-f2 in surviving neurons of ...
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Radix puerariae extracts ameliorate paraquat induced pulmonary fibrosis by attenuating follistatin like 1 and nuclear factor erythroid 2p45 related factor 2 signalling pathways through downregulation of miRNA 21 expression
... growth factor- β 1 (TGF- β 1), connective tissue growth factor (CTGF), collagen-1 and collagen III were measured by real-time ...(HO-1), nuclear factor erythroid 2p45-related ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...Kelch- like ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... NF, nuclear factor; NQO1, NAD(P)H:- quinone oxidoreductase 1; Nrf2, nuclear factor erythroid 2-related factor 2; nRNP, nuclear ribonucleoprotein; PAS, ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... radicals like hydroxyl, superoxide, alkoxyl, peroxyl, glutathiyl, tocopheroxyl, hydroperoxyl and ...diseases. Nuclear factor erythroid-2-related factor 2 is a master ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... tially clustered in association with proteins involved with the negative regulation of transcription and gene expres- sion. Several studies have also demonstrated that nickel species are also capable of negatively ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective ...(Kelch- like ECH-associated protein 1), and together they are ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... colonic tissue was extracted using a QIA shredder and RNeasy Kit (Qiagen NV, Venlo, the Netherlands) following the manu- facturer’s instructions. Quantitative RT-PCR was performed using an Eppendorf PCR system with ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... Most mammal testes suspend in a scrotum outside the body cavity and are more susceptible to heat than other organs [2,16]. Scrotal temperature above the normal range can disrupt spermatogenesis and increase rates of sub ...
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Mitochondrial reactive oxygen species and cancer
... Mitochondrial ROS modify metabolism The interplay between ROS levels and cellular metabolism is tightly regulated. Metabolic processes produce ROS, particu- larly in the mitochondria, thus metabolic fluxes need to be ...
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Inhibitory effect of phytol on cellular senescence
... The transcription factor NRF2 coordinates cellular defenses against oxidative stress by inducing antioxidant genes. Under non-stressed conditions, NRF2 exists in an inactive cytoplasmic form bound to KEAP1, an ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... The C57BL/6J mice were obtained from the Experimental Animal Center at the Fourth Military Medical University, Xi’an, China. The animals were housed at 21 ± 2°C, 12 h light/ dark cycle, and 60-70% humidity with ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... of 2 –△△ Ct (△Ct represents the difference of threshold cycle value between the target gene and the inner control; △△Ct rep- resents the difference of △Ct between different groups) was used to analyze the ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... Despite an yet unknown mechanism, a number of studies demonstrated the ability for DHA and its oxida- tive products to modulate the oxidant and inflammatory responses in microglial cells [32–36]. Studies on the vascular ...
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Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche
... chromatin-associated erythroid cell factors that play an intrinsic role in morphologically preparing the cell for proper nuclear extrusion (Ji et ...global erythroid-specific panoply of EKLF targets ...
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Characterization of biologically active, platelet derived growth factor like molecules produced by murine erythroid cells in vitro and in vivo
... growth factor (PDGF) is an important serum regulator of erythropoiesis in ...splenic erythroid cells revealed the presence of several PDGF-like ...two erythroid cell types was confirmed by ...
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