nuclear factor erythroid-related factor 2
The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia
... When finished, remove the supernatant until the remaining pellets. Add 2 ml medium into the pellet and do pipetting to homogenize. Insert the media that has been made into 2 new flasks of 5 ml each and put ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... all cell types and tissues, and is most abundant in tissues where detoxification reactions occur routinely, including the lungs. However, Nrf2 is also inducible and triggered by oxidative stress, injury, and ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... Antigen retrieval was carried out by steaming (20 minutes at 80˚C) in citrate buffer at pH 6.0. The following primary antibodies were used: a polyclonal an- ti-Nrf-2 antibody (Santa Cruz Biotechnology, CA, USA), ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... ectly related nickel-induced carcinogenesis) and induce chemokine and cytokine gene expression (nickel-driven correlated pathway to immune response) [7, ...the Nuclear factor-erythroid ...
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Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
... the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway and synthesis of heme oxygenase (HO-1), as well as to mitigate lipopolysaccharide (LPS)-induced nitric oxide ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor- erythroid 2–related factor 2 (Nrf2), a member of the “cap’n’collar” family of basic region–leucine zipper transcription factors, which has previously ...
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Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... fumarate, nuclear factor (erythroid-derived 2)-related factor 2 (Nrf2), laquinimod, and teriflunomide linked to MS, experimental autoimmune encephalomyelitis (EAE), immune ...
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Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments
... This clustering analysis suggests that different skin care needs depend on the naturally occurring single genetic vari- ants present in each one of the genetic clusters. For example, cluster 8 shows the worst combination ...
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Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis
... decreased nuclear Nrf2 accu- mulation might be attributed to other involved pathways and impaired nuclear export caused by heat ...transcription factor (Figure ...
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Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
... Abstract: Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, ...
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Inhibitory effect of phytol on cellular senescence
... necrosis factor-alpha), IL6 (interleukin 6), IL8 (interleukin 8), and COX2 (cyclooxygenase ...(nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... for 2 min, followed by 4 % paraformaldehyde dis- solved in PBS for 5 ...vessel; 2, cellular infil- tration plus demyelination in immediate proximity to the vessel; 3, cellular infiltration and demyelination ...
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Original Article Xylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
... 3, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), GFAP, NGFR, BDNF, NTRK1, and NTRK2 expression were assessed in the ischemic mouse ...
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Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury
... Adoptive transfer of Ad-HO-1 BMMs induced Akt activation and enhanced antiapoptotic gene expression in Nrf2- deficient livers, accompanied by de- creased frequency of apoptotic cells. In marked contrast, Nrf2 deficiency ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... GSH levels fall with increased oxidative stress. Other major antioxidants include: low-molecular-weight compounds such as vitamins C and E, bilirubin, and urate; non-catalytic antioxidant proteins, such as thioredoxin ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...subsequent nuclear ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... diseases. Nuclear factor erythroid-2-related factor 2 is a master transcription factor belonging to the leucine zipper ...of nuclear factor ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... There are no histopathological studies on fibrosis of the kidney in pristane-induced LN. In the present study, the upregulation of TGF-β1 expression in the kidney of pristane-injected mice was detected at the ...
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Neuroprotective effect of dimethyl fumarate in stroke: The role of nuclear factor erythroid 2-related factor 2
... Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the most important endogenous protective factors against oxidative ...
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Mitochondrial reactive oxygen species and cancer
... increase expression of antioxidants including GPXs and glutathione synthesis and utilization genes [26,27]. One mechanism of NRF2 stabilization is by ROS-mediated oxidation of sensitive cysteine residues on KEAP1 ...
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