Nuclear factor-kappa B (NF-κB)
Targeting nuclear factor kappa B to overcome resistance to chemotherapy
... Nuclear Factor-kappa B (NF-κB) is a tightly regulated tran- scription factor, composed of homo or heterodimers from a pool of five REL proteins: NF-κB1(p50), NF-κB2 (p52), RelA (p65), ...
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Nuclear Factor Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
... The aim of the present study was to investigate the status of oxidative stress in the serum of chil- dren affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched ...
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Nuclear Factor-Kappa B Expression in Oral Leukoplakia and Squamous Cell Carcinoma: An Immunohistochemical Study
... Nuclear factor kappa B has been implicated in the development of head and neck squamous cell carcinoma from premalignancy, progression to invasion, metastasis and treatment ...Transcription ...
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Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin 6 in bone infection
... Staphylococcus aureus is the major pathogen among the staphylococci and the most common cause of bone infections. These infections are mainly characterized by bone destruction and inflammation, and are often debilitating ...
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Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation
... system, nuclear factor kappa B (NF-B) acts as an inducible transcription factor that can be quickly activated in response to many noxious stimu- lants, including virus ...
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Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis.
... and nuclear fractions were immunoblotted for p65-NF-jB, nucleoporing-p62 (a nuclear marker), and b-actin (a cytoplasmic ...NF-jB, nuclear factor kappa B; QNZ, ...
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Glucocorticoid receptor and nuclear factor kappa b affect three dimensional chromatin organization
... the nuclear receptor superfamily ...tivity. Nuclear factor kappa-b (NFκB) is a heterodimeric TF that regulates various biological processes such as cell growth, development, and the ...
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Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... Nuclear factor-kappa B (NF- k B)/Rel transcription factors play an important role in the inducible regulation of a vari- ety of genes involved in the inflammatory and proliferative ...
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Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients
... growth factor 1 (somatomedin C); IML: Instituto Médico Legal; KL: Klotho; Kl −/− : Klotho knockout; LTG: lamotrigine; MRI: magnetic resonance imaging; NFkB: nuclear factor kappa B; ...
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Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells
... κ B family might have in chemotherapeutic resist- ...κ B, was found to cause sensi- tization of different tumor cells, like lung cancer cells, to the effect of chemotherapeutic drugs ...κ B family an ...
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Nuclear factor kappa B in urine sediment: a useful indicator to detect acute kidney injury in Plasmodium falciparum malaria
... that nuclear factor-κB (NF-κB) is activated in the renal tubular epithelial cells, glomeruli and urothe- lial cells in renal injury [14,15] and that renal inflamma- tion can occur after induction by a ...
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Activation of nuclear factor kappa B in peripheral blood mononuclear cells from malaria patients
... The process of malaria pathogenesis is very complex and still poorly understood. Several studies have indi- cated that the expression of adhesion molecules on vas- cular endothelial cells and the production of pro- ...
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Combining oral contraceptives with a natural nuclear factor-kappa B inhibitor for the treatment of endometriosis-related pain
... κ B action may constitute a new approach that will not only increase the efficacy of hormonal treatment in inducing long-lasting amenorrhea but will also reduce endometriosis pain ...
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Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection
... including nuclear factor B (NF- B), IFN regulatory factor 3 (IRF3), IRF7, and the activating transcription factor 2/cellular Jun protein complex (ATF2/ cJun, also named AP-1) ...
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The role of A20 in the pathogenesis of lymphocytic malignancy
... Moreover, microRNA dysfunction can contribute to the constitutive activation of different signaling pathways such as the NF-κB pathway. miR-125a and miR-125b overexpression has been linked with dysfunctional ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B
... B-Fluc reporter plasmid, the pSV40-RL control vector, and LCMV-NP wild type or mutants containing alanine (A) substitutions at positions D382, I383, E384, G385, R386, D459, H517, and D522 ... B via SeV ...
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Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain
... are membrane-associated proteins among tight junction complexes that are anchored to the cytoskeleton architec- ture via occludin [12, 13]. Although TJ complexes have been well established, little is known about ...
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Ionizing radiation induces expression and binding activity of the nuclear factor kappa B
... transcription factor NF-kappa ...of nuclear factor (NF)kappa ...NF-kappa B binding activity was maximal at 2-4 h and then declined to pretreatment ...NF-kappa ...
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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
... k B a ...k B activation ...k B a could take place in the presence of ...and nuclear proteins were extracted. Cytoplasmic and nuclear extracts were analyzed by Western blotting using ...
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