nuclear factor-like 2
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
... ankle; 2 = slight edema and erythema from the ankle to the tarsal bone; 3 = moderate edema and erythema from the ankle to the tarsal bone; and 4 = edema and erythema from the ankle to the entire leg ...
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Nuclear Factor Erythroid 2 Related Factor 2 and Heme Oxygenase 1 Protein Expression and Clinicopathological Features in Glioblastoma
... binding to the homodimeric protein Kelch-like erythroid cell-derived protein with CNC homology associated protein 1 (Keap1) in the cytosol under un- stressed conditions. Studies of Nrf-2 have suggested that ...
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Oxidative stress in sepsis: a redox redux
... that nuclear factor-erythroid 2–related factor 2 (Nrf2, also known as Nfe2l2), which encodes a basic region–leucine zipper transcription fac- tor, is a key regulator of the cellular ...
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Anti TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
... colony-stimulating factor; HO-1: heme oxygenase 1; HRP: horse radish peroxidase; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; IL: interleukin; LPS: lipopolysaccharide; mRNA: messenger RNA; NADPH: nicotinamide ...
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Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
... hepatocyte nuclear factor 1-alpha; HNF4a: hepatocyte nuclear factor 4-alpha; HepLPCs: liver progenitor-like cells; iHepLPCs: Immortalized HepLPCs; iHepLPCs-Hep: hepatocyte-like ...
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Chlamydial Protease Like Activity Factor and Type III Secreted Effectors Cooperate in Inhibition of p65 Nuclear Translocation
... Comparative proteomics of WT and CPAF null infections identifies host proteins functional in innate immunity as CPAF targets. The proteomic analysis of WT-, null-, and mock-infected cells identified a total of 6,228 host ...
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Original Article Protective effects of hyperbaric oxygen treatment against spinal cord injury in rats via toll-like receptor 2/nuclear factor- B signaling
... Spinal cord injury (SCI) is a serious medical problem with high costs to healthcare, as well as social and psychological burdens. Trauma to the SC can cause irrecoverable primary dam- age by destroying tissue as well as ...
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Nuclear factor erythroid 2 related factor 2 is a critical target for the treatment of glucocorticoid resistant lupus nephritis
... expression of antioxidant response element (ARE)- dependent genes, such as those encoding antioxidant and detoxifying enzymes like heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) [6]. Under ...
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Case Report Mammary carcinoma with osteoclast-like giant cells: a case report
... that 2% of breast carci- noma ...osteoclast like giant cell compo- ...growth factor receptor 2, receptor activator of nuclear-kB, RANK ligand, and matrix metalloproteinase 1 are ...
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Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
... the nuclear factor erythroid-2-related factor 2 (Nrf2) as it regulates the transcription of ROS-protective ...(Kelch- like ECH-associated protein 1), and together they are ...
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Impact of chromium histidinate on high fat diet induced obesity in rats
... Nuclear factor erythroid 2-related factor 2 controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative ...Kelch- like ECH-associated ...
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African Swine Fever Virus IAP-Like Protein Induces the Activation of Nuclear Factor Kappa B
... Cellular proteins of the family of baculovirus IAPs, including several human IAP relatives, have been shown to interfere with apoptotic processes (8). Part of this ability is mediated by their direct inhibition of ...
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NRF2 and p53: Januses in cancer?
... transcription factor nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or NRF2, is a master regulator of the anti-oxidative stress response and positively ...
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An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress
... radicals like hydroxyl, superoxide, alkoxyl, peroxyl, glutathiyl, tocopheroxyl, hydroperoxyl and ...diseases. Nuclear factor erythroid-2-related factor 2 is a master ...
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Nuclear factor erythroid 2 – related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis
... tially clustered in association with proteins involved with the negative regulation of transcription and gene expres- sion. Several studies have also demonstrated that nickel species are also capable of negatively ...
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Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease
... All patients underwent pulmonary function testing. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV 1 ), FEV 1 % (FEV 1 /FVC), diffusing capacity of the lungs for carbon monoxide (DL CO ), and DL CO ...
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Changes in Monocyte Chemoattractive Protein, Nuclear Respiratory Factor 2, B-Cell Leukemia/Lymphoma 2 and Cholinesterase in Serum of Autistic Children
... in the antiapoptotic factor -cell leukemia/lymphoma 2 (Bcl2) in serum. The Bcl2 family of proteins is important in maintaining mitochondrial membrane integrity and in regulating the mitochondrial pathway of ...
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Integration of flow dependent endothelial phenotypes by Kruppel like factor 2
... tected region of the human carot- id, we blocked the flow-induced upregulation of KLF2 using small interfering RNA (siRNA) gene silencing. KLF2 was knocked down in cells exposed to flow such that the KLF2 level was ...
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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking
... Cigarette smoke induces alveolar cell apoptosis leading to alveolar wall destruction and emphysema. Therefore, we employed A549 cells derived from adenocarcinomic human alveolar basal epithelial cells for in vitro ...
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Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
... antagonist of S1P1Rs, although binding of arrestins to S1P1Rs may redirect signaling to alternative G-protein-independent pathways. Fingolimod phosphate can also activate S1P3Rs, S1P4Rs, and S1P5Rs, but not S1P2Rs ...
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