nuclear-localization
Identification of the Nuclear Export and Adjacent Nuclear Localization Signals for ORF45 of Kaposi's Sarcoma-Associated Herpesvirus
... 1)-dependent nuclear export, suggesting that it could shuttle between the nucleus and ...leucine-rich-like nuclear export signal and an adjacent nuclear localization ...subcellular ...
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Classic Nuclear Localization Signals and a Novel Nuclear Localization Motif Are Required for Nuclear Transport of Porcine Parvovirus Capsid Proteins
... as nuclear localization signal ...VP2 nuclear localization and is called the nuclear localization motif (NLM) since it is dependent on the correct folding of the ...potential ...
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The directionality of the nuclear transport of the influenza A genome is driven by selective exposure of nuclear localization sequences on nucleoprotein
... two nuclear localization sequences (NLS1, spanning resi- dues 1–13 at the N terminus, and NLS2, spanning resi- dues 198–216 in the middle of the protein) that mediate the nuclear import of NP and ...
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Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport.
... resembled nuclear localization signals (NLS) of both the simian virus 40 type and the bipartite type were found in the primary structure of ...impaired nuclear localization of the truncated ...
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Novel Nuclear Herniations Induced by Nuclear Localization of a Viral Protein
... the nuclear lamina can grossly alter nuclear shape, induce nuclear herniations and NPC clustering, and alter chromatin organization (10, 13, 21, 23, 36, ...NPCs, nuclear herniations, chromatin ...
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Characterization of the Nuclear Localization and Nuclear Export Signals of Bovine Herpesvirus 1 VP22
... The nuclear localization of HSV-1 VP22 has been suggested to modulate the transcription or replication of host cells, per- haps preparing them for infection (5, ...subcellular localization of VP22 in ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... cellular localization, is not well understood, although some researchers have demon- strated the subcellular distribution of VP1 in cells using transient protein expression and immunofluorescence assays [11, ...of ...
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Conserved Region CR2 of Epstein-Barr Virus Nuclear Antigen Leader Protein Is a Multifunctional Domain That Mediates Self-Association as well as Nuclear Localization and Nuclear Matrix Association
... GAL4 activation domain in the yeast two-hybrid system. The site of the W2 domain of EBNA-LP required for self-associa- tion mapped to the amino acid region between Gly-19 and Ser-39 (relative to the first amino acid ...
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RUNX1 Permits E4orf6-Directed Nuclear Localization of the Adenovirus E1B-55K Protein and Associates with Centers of Viral DNA and RNA Synthesis
... clear localization of E1B-55K in transfected mouse ...the localization of E1B-55K in the presence of the E4orf6 protein was scored as cytoplasmic or nuclear as described for ...direct nuclear ...
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The role of nuclear localization signal in parvovirus life cycle
... more nuclear localization signals (NLSs), which are required for guiding the virus particle into the nucleus through the nuclear ...potential nuclear localization sequences, named basic ...
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Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.
... of nuclear localization mutants of ICP27 on the localization of other viral proteins involved in late gene ex- pression and DNA ...the localization of both of these immedi- ate-early proteins ...
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Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members.
... multifunctional nuclear protein. LT has two nuclear localization signals (NLSs), one spanning residues 189 to 195 (NLS1) and another spanning residues 280 to 286 ...a nuclear LT bearing an ...
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Nuclear Import of Epstein-Barr Virus Nuclear Antigen 1 Mediated by NPI-1 (Importin α5) Is Up- and Down-Regulated by Phosphorylation of the Nuclear Localization Signal for Which Lys379 and Arg380 Are Essential
... (EBV) nuclear antigen 1 (EBNA-1) is essential for replication of episomal EBV DNAs and maintenance of ...on nuclear translocation of Ser phosphorylation of the EBNA-1 nuclear localization ...
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Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.
... subcellular localization of NS3 and factors affecting the localization might give us some clues of the pos- sible influence of NS3 on host cell ...a nuclear localization signal is present in ...
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Identification of Nuclear and Nucleolar Localization Signals of Pseudorabies Virus (PRV) Early Protein UL54 Reveals that Its Nuclear Targeting Is Required for Efficient Production of PRV
... Pseudorabies virus (PRV), a typical alphaherpesvirus, is an economically important pathogen of swine. The neurotropic nature of PRV makes it a useful tracer of neuronal connec- tions, and it is also a useful model for ...
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A nuclear targeting system in Plasmodium falciparum
... Background: The distinct differences in gene control mechanisms acting in the nucleus between Plasmodium falciparum and the human host could lead to new potential drug targets for anti-malarial development. New molecular ...
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Modulation of p53 Cellular Function and Cell Death by African Swine Fever Virus
... For many viruses, replication depends on the induction of S phase, which often leads to increased levels of p53. Since activation of p53 can induce apoptosis, such viruses have evolved strategies for counteracting either ...
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Nuclear import of influenza A viral ribonucleoprotein complexes is mediated by two nuclear localization sequences on viral nucleoprotein
... To track the nuclear import of the influenza genome, the vRNA within the purified vRNP complex was biotinylated in order to attach a streptavidin fluorophore. For this pur- pose, we used the 5' End Tag Nucleic ...
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Towards defining the nuclear proteome
... subcellular localization predictors' able to predict the subcel- lular localization of a protein to one or more of several speci- fied ...the nuclear proteome, we selected five of these methods using ...
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Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus
... of nuclear Int6 upon coexpression of ...a nuclear protein, we investigated the structural basis of this ...bipartite nuclear localization signal and a nuclear export signal at the far ...
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