Nuclear Localization Signal (NLS)
Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS
... minor NLS-binding pocket of importin ...function, NLS score. NLS score is the sum of the normalized number of inter-atomic bonds, net hydrophobic/hydrophilic residues, and atomic contact energies ...
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Functional exchangeability of the nuclear localization signal (NLS) of capsid protein between PCV1 and PCV2 in vitro: Implications for the role of NLS in viral replication
... the nuclear accumu- lation of PCV1 and PCV2 capsid protein are properly mediated by their distinct NLS motifs ...the NLS of PCV ORF2 would play an accessory role in viral replication due to its con- ...
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Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
... subcellular localization of viral proteins, especially in the nucleus, may contribute to cell apoptosis, viral replication or host cell proliferation [9, ...the nuclear localization signal ...
9
Characterization of the Nuclear Localization Signal of the Borna Disease Virus Polymerase
... the nuclear envelope to associate with the genomic viral ...cells. Nuclear local- ization of the protein presupposes the presence of a nuclear localization signal (NLS) within ...
8
The role of nuclear localization signal in parvovirus life cycle
... for nuclear targeting of VP2 ...the nuclear localization signal of B19 VP2 capsid protein, the localization of full-length VP2 (aa VP 228-781) protein and a C-terminal, truncated form ...
6
Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF)
... the localization of the ...bipartite NLS was identified in every PH domain analyzed using cNLS mapper and many identified obtained a score about ...nucleus localization has not been identified ...
127
Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl
... The mutant protein (p.F157Lfs*5) results in a partial loss of kinase domain and a complete loss of the C-terminal domain compared to the wild type.. NLS, Nuclear localization signal, NRD[r] ...
5
Bräuer, Katharina Elisabeth Marianne (2018): Activity and substrate specificity of bacterial and human ribosomal oxygenases. Dissertation, LMU München: Fakultät für Biologie
... Wild type OGFOD1 exhibits the catalytically active N-terminal DSBH domain containing the iron coordinating HxD...H motif and a C-terminal DSBH lacking the iron-binding motif. N- terminal and C-terminal DSBH domains are ...
131
A nuclear targeting system in Plasmodium falciparum
... bipartite signal sequence to facilitate apicoplast targeting and membrane translocation ...a nuclear targeting technique in ...a nuclear carrier ...A nuclear localiza- tion signal ...
5
Interactions and Nuclear Import of the N and P Proteins of Sonchus Yellow Net Virus, a Plant Nucleorhabdovirus
... The N and P proteins interact physically. Our previous studies (54) have revealed that N, P, and L interact with the genomic RNA to form a rapidly sedimenting nucleocapsid polymerase core complex. More slowly sedimenting ...
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Possible Role for Cellular Karyopherins in Regulating Polyomavirus and Papillomavirus Capsid Assembly
... of nuclear import factors as possible “chaperones” in preventing the cytoplasmic assembly of papovavirus ...a nuclear localization signal (NLS)-dependent ...the NLS of VP1 and L1 ...
10
Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis
... predominantly nuclear localization of Apoptin in tumor cells, whereas in normal cells, it is detected mainly in cytoplasmic ...of nuclear localization for Apoptin-induced cell death in tumor ...
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Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus
... is nuclear and localized in the PML ...authentic nuclear localization signal and an NES ...is nuclear because their cDNA clone (Int6A) was missing a few residues at the N terminus of ...
8
Phosphorylation meets nuclear import: a review
... on nuclear import, and unfortunately the molecular consequences of phosphorylation have been elu- cidated in very few systems ...affects nuclear import is a difficult task and likely many more cargos than ...
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H IPSE is a pathogen secreted host nucleus infiltrating protein (infiltrin) expressed exclusively by the Schistosoma haematobium egg stage
... the NLS in H-IPSE is fully functional, and bearing in mind that the sequence cannot be functional within schistosome eggs themselves, as the N-terminal CSS will target the protein for secretion well before the ...
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Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx
... the same sequence [61]. A valid explanation for this selec- tive transactivation pattern, which apparently does not affect integrated sequences, would be its predominance in inactive chromatin compartments that have no ...
19
Tip60 Tumor Suppressor Requires Its NLS Motif to Interact with Importin α
... DOI: 10.4236/cellbio.2019.81001 2 CellBio characterized as a specific member of MYST (Moz-Ybf2/Sas3-Sas2-Tip60) fami- ly of nuclear histone acetyltransferases (HATs) [1] [2] [3]. To elucidate its bio- logical ...
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The role of Notch signalling in ovarian angiogenesis
... The ovary is an important organ to study angiogenesis and vascular function. In this review, we highlighted the expression pattern of Notch signalling pathway elements in the ovary and key roles for regulatory Notch ...
8
Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
... the nuclear import of sev- eral basic, nucleic-acid binding proteins such as histones and ribosomal proteins, but does so using adapter Importins other than Impα ...that nuclear import of ASV IN might ...
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Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization
... facilitate localization studies and displays activity comparable to that of ...Tag), NLS, leucine zipper region (LZL), NES, activation domain (ACT), and GFP fusion ...
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