Nuclear receptor coactivator 1
The Role of NCOA4-Mediated Ferritinophagy in Iron Homeostasis
... transferrin receptor: TfR, DMT1), export (ferroportin: FPN), storage (ferritin: FTH1/FTL), and a host of additional iron homeostasis regulatory circulating and intracellular ...for Nuclear Receptor ...
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SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
... Quite a few studies have been performed on the mechanism of SRC-3 regulating the IGF-I signaling in cancers. SRC-3 can bind to the transcription factor AP-1 and enhance AP-1-mediated transcription of IGF-I ...
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Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and Small Heterodimer Partner Differentially Regulate Nuclear Receptor-Dependent Hepatitis B Virus Biosynthesis
... (Fig. 1 to 6) (27a) indicated that the effects of PGC1 ␣ and SHP on viral replication in Huh7 cells were most similar to those observed in 293T cells express- ing ERR ␣ (Correlation coefficient r ⫽ ...one ...
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Responses to temperature variation: integration of thermoregulation and metabolism in vertebrates
... activated receptor γ coactivator 1 α (PGC-1 α ), which modulates metabolism in response to multiple stimuli such as exercise, diet and temperature (Puigserver et ...the nuclear and ...
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Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation
... Steroid receptor coactivator 3 (SRC-3/ACTR/AIB-1/ pCIP/TRAM-1), is a member of p160 coactivator ...with nuclear hormone recep- tors but also interacts with other transcription ...
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Peroxisome proliferator–activated receptor γ coactivator 1 promotes cardiac mitochondrial biogenesis
... of nuclear and mitochondrial genes during mitochondrial biogenesis, several important questions regarding the regulation of mitochondrial functional capacity ...NRF- 1 or NRF-2 in the transcriptional ...
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Two new splice variants in porcine PPARGC1A
... proliferator-activated receptor γ coactivator 1 α (PPARGC1A) is a transcriptional coactivator with many diverse functions and has a pivotal role in fat and energy ...of nuclear hormone ...
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The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer
... helix-loop-helix-Per/Ah receptor nu- clear translocation/Sim (bHLH/PAS) motif and is the most conserved region among the SRC family mem- bers with 75% similarity ...bipartite nuclear localization signal ...
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Human Papillomavirus E7 Oncoprotein Dysregulates Steroid Receptor Coactivator 1 Localization and Function
... steroid receptor coactivator 1 (SRC-1), a component of steroid hormone ...steroid receptor coactivator family required for full transcriptional activity of the steroid ...
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Identification and Characterization of the Alternatively Spliced Nuclear Receptor Coactivator-6 Isoforms
... as nuclear interaction mo- ...estrogen receptor (ER) ...X receptor (LXR )-regulated lipogenesis and cholesterol/bile acid homeostasis in the liver ...multiple coactivator complexes, ...
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How Language Policies and Practices Affect Classrooms in Schools and Colleges
... cancer 1) and SRC-1 (steroid receptor coactivator-1) are both nuclear receptor coactivators that interact with nuclear hormone receptors to enhance their ...
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An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
... One central aspect of muscle fiber-type determination is that it represents a fairly stable, ‘‘differentiation-like’’ response. Muscle fiber types ordinarily can be altered only through pro- longed physical activity or ...
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Case Report Mammary carcinoma with osteoclast-like giant cells: a case report
... [9]. Receptor activator of nuclear- (RANK), RANK ligand (RANKL), and matrix me- talloproteinase 1 (MMP1) are absent or not overexpressed in the current ...
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Recruitment of the Transcriptional Coactivator HCF-1 to Viral Immediate-Early Promoters during Initiation of Reactivation from Latency of Herpes Simplex Virus Type 1
... exhibit nuclear HCF-1 localization increases over the course of 6 h poststimulation (11, ...0, 1, or 4 h. As shown in Fig. 1B and C, HCF-1 occupancy was reproducibly detected as early as ...
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Knockdown of peroxisome proliferator-activated receptor gamma coactivator-1 alpha increased apoptosis of human endometrial cancer HEC-1A cells
... The cells were collected after 72 hours of transfection, washed twice with phosphate-buffered saline (PBS), incu- bated in radioimmunoprecipitation assay buffer (1 × PBS, 1% NP40, 0.5% sodium deoxycholate, ...
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Association of the Cellular Coactivator HCF-1 with the Golgi Apparatus in Sensory Neurons
... PFU of HSV-1 (strain 17) per eye after corneal scarification. Latently infected mice were sacrificed 45 days postinfection, and trigeminal ganglia were rapidly removed. Latency establishment was confirmed by ...
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Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer
... ferrin receptor-1 through small hairpin RNA (shRNA) leads to decrease in iron uptake, high HIF expression and extensive angiogenesis in breast cancer cell lines ...
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The nuclear corepressor 1 and the thyroid hormone receptor suppress breast tumor lymphangiogenesis
... The role of NCoR and TRβ as potent regulators of the VEGF-C and VEGF-D genes was confirmed in vivo using xenografts. Thus, TRβ expression resulted in reduced transcript levels of these genes in the tumors, while NCoR ...
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Fate of the Inner Nuclear Membrane Protein Lamin B Receptor and Nuclear Lamins in Herpes Simplex Virus Type 1 Infection
... addition, nuclear lamins contain a nuclear localization signal (31) and a C- terminal target site for posttranslational modification (isopre- nylation) which increases hydrophobicity and is required for ...
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Impaired SUMOylation of nuclear receptor LRH 1 promotes nonalcoholic fatty liver disease
... The excessive accumulation of hepatic lipids and increased de novo lipogenesis could also have other causes. A previous study using liver-specific Lrh-1 knockout mice showed that LRH-1 pro- motes ...
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