Nuclear Transcription Factor Kappa B
Original Article N,N’ -diacetylcystine ameliorates inflammation in experimental non-alcoholic steatohepatitis by regulating nuclear transcription factor kappa B activation
... Reverse transcription (RT) of total RNA (2 μg) was performed following the manufacturer’s instructions (Promega, Beijing, China) in a final volume of 12 ...
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Targeting nuclear factor kappa B to overcome resistance to chemotherapy
... The efficacy of targeted therapy is based on the oncogenic dependence of cancer cells on mutated survival and apoptotic pathways, such as NF-κB, which renders them more susceptible to inhibitors. NF-κB is a master ...
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Immunosuppressant FK506 induces interleukin 6 production through the activation of transcription factor nuclear factor (NF) kappa(B) Implications for FK506 nephropathy
... k B-dependent tran- scription, we next studied whether FK506 induces NF- k B acti- ...vation. Nuclear extracts were prepared from L-TK cells treated for 30 min with 1 or 10 m M FK506 and were ...
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Activated transcription factor nuclear factor kappa B is present in the atherosclerotic lesion
... k B dimer is present in the cytosol bound to an inhibitory protein, I k B (5, ...k B by a multitude of stimuli, in- cluding inflammatory cytokines, reactive oxygen intermedi- ates, and microorganisms ...
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Glucocorticoid receptor and nuclear factor kappa b affect three dimensional chromatin organization
... Recent 3C-based studies of individual loci reported on the role of GR and NFκB in long-range gene regulation [10, 13, 48]. For example, the Lcn2 gene locus is engaged in multiple long-range contacts with GR DBS. In ...
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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B
... k B activation by sodium salicylate at higher concentrations in SW620 cells or Jurkat T ...k B–medi- ated transcription ...k B or AP1 path- ways and c-AMP–dependent signal transduction, the ...
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MicroRNAs and Their Role in Bone Remodeling and Pathogenesis
... of nuclear factor kappa-B ligand; M-CSF - macrophage colony- stimulating factor; TRAP - Tartrate-resistant acid phosphatise; CTR - Calcitonin receptor; pri-microRNA - Primary microRNA; ...
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Arenavirus Nucleoproteins Prevent Activation of Nuclear Factor Kappa B
... B and activator protein 1 (AP-1), whereas later induction of IFN-␣ forms is mainly dependent on IRF7 and, to a lesser extent, IRF3 (20, 28, ... B comprises a family of tran- scription factors found ...
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Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells
... Cocaine treatment activated NF-κB in PC12 cells in the interval of 3–8 hours while cell death was more pro- nounced after 24 hours only. Supershift assay analysis indicated that cocaine increased the p50/p65 NF-κB com- ...
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Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection
... reverse transcription-PCR (RT- PCR) assay was used to evaluate the mRNA levels of porcine IFN-, RelA, tumor necrosis factor alpha (TNF- ␣ ), and RANTES and viral genome ...
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The role of A20 in the pathogenesis of lymphocytic malignancy
... Moreover, microRNA dysfunction can contribute to the constitutive activation of different signaling pathways such as the NF-κB pathway. miR-125a and miR-125b overexpression has been linked with dysfunctional ...
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Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and release of interleukin 6 in bone infection
... the transcription of many NFkB-dependent genes, which include growth factors, adhesion molecules, chemokines and cytokines (Ning et ...increased transcription, but not increased protein synthesis or ...
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Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation
... system, nuclear factor kappa B (NF-B) acts as an inducible transcription factor that can be quickly activated in response to many noxious stimu- lants, including virus ...
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Ionizing radiation induces expression and binding activity of the nuclear factor kappa B
... the transcription factor NF-kappa ...of nuclear factor (NF)kappa ...NF-kappa B binding activity was maximal at 2-4 h and then declined to pretreatment ...
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Nuclear Factor Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
... The aim of the present study was to investigate the status of oxidative stress in the serum of chil- dren affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched ...
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Effects of Pulsed Electromagnetic Fields of Different Frequencies on the Gene Expression of RANK and NFATc1 in Rat Osteoclasts Co Cultured with Osteoblasts
... of nuclear factor kappa B ligand (RANKL)/receptor activator of nuclear factor kappa B (RANK)/osteoprotegerin (OPG) ...osteoclastogenesis-specific ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...of transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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Regulation of Proinflammatory Cytokine Expression in Primary Mouse Astrocytes by Coronavirus Infection
... B binding sites, a calcium- and cyclic-AMP-responsive element (CRE), and an AP-1 and Sp1 cis-binding site ...basal transcription of TNF- ␣ is controlled by Sp1, inducible expression of TNF- ␣ is likely ...
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Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients
... growth factor 1 (somatomedin C); IML: Instituto Médico Legal; KL: Klotho; Kl −/− : Klotho knockout; LTG: lamotrigine; MRI: magnetic resonance imaging; NFkB: nuclear factor kappa B; ...
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Anti-inflammatory effects of prunin on UVB-irradiated human keratinocytes
... of transcription factors. Macro- phages express the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B) in response to ...
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