nuclear transcription factor-κB
Original Article Expression of NF-κB and PCNA in gastric mucosa-associated lymphoid tissue lymphoma and its clinical significance
... of nuclear transcription factor κB (NF-κB) and PCNA in gastrric mucosa-associated lymphoid tissue (MALT) lymphoma, and analyze its relationship with clinicopathological char- ...
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Nuclear transcription factor Nrf2 suppresses prostate cancer cells growth and migration through upregulating ferroportin
... Previous studies found iron metabolism associated with cancer cell growth and metastasis [3–5]. The accumulation of intracellular irons can promote the growth and aggression of cancer cells, while low levels of ...
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Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
... The transcriptional regulation of the changes noted are not completely understood. The increases in TF, PAI-1, and uPA are most likely to be due to the increased secretion of cytokines such as IL-1 and TNF-α, which are ...
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Reovirus-Induced Apoptosis Requires Activation of Transcription Factor NF-κB
... Many viruses are capable of inducing programmed cell death, which results in apoptosis of infected cells (43, 45, 52, 60). Apoptotic cell death is characterized by cell shrinkage, membrane blebbing, condensation of ...
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Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression.pdf
... gene transcription is a hallmark of the activated B-cell-like subset of diffuse large B-cell leukemia (Lam et ...necrosis factor (TNF) receptor family member that is expressed in a variety of B-cell ...
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Control of oncogenesis and cancer therapy resistance by the transcription factor NF κB
... Further support for the involvement of NF-κB in onco- genesis comes from experiments in which the NF- κ B pathway has been directly perturbed. Inhibition of NF- κ B by expression of a modified form of I κ B α ...
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Anti Inflammatory properties of Salograviolide A purified from Lebanese plant Centaurea ainetensis
... IL-1, a pro-inflammatory cytokine, is produced by many inflammatory cell types in response to a variety of stimuli [2]. It has been shown to be increased in the intestinal mucosa of IBD patients and in animal models of ...
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Science review: Redox and oxygen sensitive transcription factors in the regulation of oxidant mediated lung injury: role for nuclear factor κB
... The molecular response to oxidative stress is regulated, in part, by redox-sensitive transcription factors. The study of gene expression/regulation is critical in the development of novel gene therapies ...
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The transcription factor NF-κB control of oncogenesis and cancer therapy resistance.pdf
... (HTLV-I) transcription- ally activates ...protein nuclear antigen 2 (EBNA2) and the latent membrane protein (LMP), the Simian virus-40 (SV-40) encoded large-T, and adenovirus encoded E1A, all stimulate ...
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The roles of the classical and alternative nuclear factor kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis
... growth factor genes and IL-17Rs and Toll and IL-1R), which is distantly related to the Toll and IL-1R (TIR) ...NF- κB binding sites and these appear to function cooperatively on DNA to promote ...
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Series Introduction: The transcription factor NF κB and human disease
... NF-κB can be activated within minutes by a variety of stimuli, including inflammatory cytokines such as TNF-α and IL-1, T-cell activation signals, growth fac- tors, and stress inducers. The activation of ...
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A synergistic interaction between transcription factors nuclear factor-κB and signal transducers and activators of transcription 3 promotes gastric cancer cell migration and invasion
... In the initial steps of metastasis of carcinoma cells, epi- thelial cancer cells change their phenotype to mesenchy- mal phenotype and become motile and invasive by a process called epithelial-mesenchymal transition ...
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Original Article GF109203X attenuates RANKL-induced osteoclastogenesis and suppresses osteolysis in a mouse model
... sis factor (TNF) super family, and is primarily secreted by the ossification cells, T lympho- cytes, and B lymphocytes ...of nuclear factor kappa B (NF-κB) into the nucle- us, which prevents ...
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Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications
... growth factor 2; HNF1A: Hepatocyte nuclear factor 1A; HNSCC: Head and neck squamos cell carcinoma; HOX10A: Homeobox- leucine zipper 10 A protein; IC: Intracellular; ICD: Intracellular domain; IGF-1: ...
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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
... growth factor starvation ...of transcription factor nuclear factor kappa B (NF-κB) in a subset of aged cells and plays a role in mediating inflammatory ...
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A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
... as transcription [14, 113, 114], cell cycle[115], apoptosis[116], senescence[117] and viral infection [118-120] is slowly ...specific nuclear processes such as transcrip- tion and DNA related ...
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Effect of pulsed electromagnetic field on inflammatory pathway markers in RAW 264.7 murine macrophages
... (p65) Transcription Factor Assay Kit, catalog #89859; Thermo Fisher Scientific, Waltham, MA, USA) was used to test NFkB activation in the inflammatory ...
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TNF Super Family Members OPG, RANKL, RANK and Osteoporosis: a link
... of nuclear factor kappa B (RANK), a member of the TNF receptor superfamily, is a type É transmembrane protein containing four cysteine-rich pseudorepeat domains in the extracellular region, a hallmark of ...
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Oxidation in rheumatoid arthritis
... hypoxia-inducible factor-1 α and nuclear factor- κ B, two key transcription factors that are regulated by changes in cellular oxygenation and cytokine stimulation, and that in turn orchestrate ...
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... important factor for preterm labor related to inflammation (COX-2 and prostaglandin) is NF- κB which is activated by numbers of inflammatory mediators, including cytokines and lipopolysaccharide ...
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