Nucleocytoplasmic Transport
Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy
... blocks nucleocytoplasmic transport and prevents RNA export and nuclear shuttling of signaling ...of nucleocytoplasmic transport results in cell ...of nucleocytoplasmic transport ...
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Signals for Bidirectional Nucleocytoplasmic Transport in the Duck Hepatitis B Virus Capsid Protein
... to transport their infecting genome through the cytoplasm to- wards and into the ...cellular nucleocytoplasmic transport machinery for targeting the nucleocapsid to the nuclear pore, where the ge- ...
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The Fission Yeast Schizosaccharomyces pombe Has Two Importin-α Proteins, Imp1p and Cut15p, Which Have Common and Unique Functions in Nucleocytoplasmic Transport and Cell Cycle Progression
... Nucleocytoplasmic transport is also dependent on the Ran GTPase (Spi1p in fission yeast), an evolution- arily conserved GTPase whose nucleotide-bound state is regulated by a nuclear, chromatin-bound, ...
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E1B 55-Kilodalton-Associated Protein: a Cellular Protein with RNA-Binding Activity Implicated in Nucleocytoplasmic Transport of Adenovirus and Cellular mRNAs
... the transport and ac- cumulation of viral mRNAs while simultaneously blocking the same process for most host ...for nucleocytoplasmic transport of mRNAs from the sites of host cell transcription and ...
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Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein
... NEP transport, the subcellular localization of NEP was observed in an energy depletion ...active nucleocytoplasmic transport is blocked, whereas passive diffusion is unaffected ...in transport ...
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Flexible Gates: Dynamic Topologies and Functions for FG Nucleoporins in Nucleocytoplasmic Transport
... to nucleocytoplasmic translocation, and current evidence supports a model of multiple low-affinity binding events between a transport receptor and FG-Nups during ...to transport receptors, ...
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Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis
... Oligodendrocyte precursor cells (OPCs) persist near the demyelinated axons arising in MS but inefficiently differentiate into oligodendrocytes and remyelinate these axons. The pathogenesis of differentiation failure ...
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Characterization of the ptr6+ Gene in Fission Yeast: A Possible Involvement of a Transcriptional Coactivator TAF in Nucleocytoplasmic Transport of mRNA
... mRNA transport is a Schizosaccharomyces pombe homologue of yTAFII67 and ...the nucleocytoplasmic transport of mRNA in addition to the transcription of the protein-coding ...
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Targeting nucleocytoplasmic transport in cancer therapy
... protein transport is crucially involved in the pathophysiology of a broad range of human cancers, it offers novel molecular targets at many different levels to normalize or to interfere therapeutically with ...
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Structural Elements of the tRNA TΨC Loop Critical for Nucleocytoplasmic Transport Are Important for Human Immunodeficiency Virus Type 1 Primer Selection
... vitro-transcribed tRNA transfected into the cytoplasm by- passes the normal cellular transport processes for tRNA and, as a result, is not used during protein synthesis. Understanding of the primer selection ...
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Mutations in the YRB1 Gene Encoding Yeast Ran-Binding-Protein-1 That Impair Nucleocytoplasmic Transport and Suppress Yeast Mating Defects
... yrb2⌬::HIS3 yrb1-52, the growth defect was even more ing, presumably, the ability of these mutations to sup- severe than for the corresponding double mutant with press mating defects. Far1 and Ste5 are currently the ...
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Rotavirus Prevents the Expression of Host Responses by Blocking the Nucleocytoplasmic Transport of Polyadenylated mRNAs
... PABPC is a nucleocytoplasmic shuttling protein (45), although its steady-state localization is cytoplasmic. It was recently reported that increasing the nuclear abundance of PABPC drives hyperade- nylation and ...
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Cell Biology of the Caenorhabditis elegans Nucleus
... cytoplasmic transport are highly conserved and here we will focus on examples from ...Instead, nucleocytoplasmic transport relies on association of substrates with either import or export trans- port ...
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Borna Disease Virus Nucleoprotein Requires both Nuclear Localization and Export Activities for Viral Nucleocytoplasmic Shuttling
... In addition, the production of the N isoform lacking NLS in infected cells may be one of the most unique mechanisms for the transport and replication of BDV. The p38N protein would be necessary for the nuclear ...
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Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases
... Similar trends were also observed in mCherry-RelA-infected cells (Fig. 9E). This cytokine-inducing transcription factor became nuclear at least 1 h earlier during B04 and B52 infections than with B14 or A16, but the ...
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Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
... and nucleocytoplasmic transport defects [21, 39, 62, ...including nucleocytoplasmic transport, stress granule (SG) dynamics, and protein translation [17, 25, 29, 41, 52, 54, 57, ...
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The F box protein ZEITLUPE controls stability and nucleocytoplasmic partitioning of GIGANTEA
... Nucleocytoplasmic partitioning of core clock components is essential for the proper operation of the circadian system. Previous work has shown that the F-box protein ZEITLUPE (ZTL) and clock element GIGANTEA (GI) ...
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RNA Binding by the Herpes Simplex Virus Type 1 Nucleocytoplasmic Shuttling Protein UL47 Is Mediated by an N-Terminal Arginine-Rich Domain That Also Functions as Its Nuclear Localization Signal
... RNA transport predominantly at late times in infection (47), and therefore an alternative factor may be involved in RNA transport at earlier times in ...
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Nucleocytoplasmic Shuttling by Human Immunodeficiency Virus Type 1 Vpr
... import properties of Vpr, this 14-kDa viral protein (and deriv- ative mutants or Vpr fragments) was fused to the C terminus of a GFP (33 kDa)-PK (55 kDa) chimera to generate an easily monitored large protein complex ...
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Genome Segregation and Packaging Machinery in Acanthamoeba polyphaga Mimivirus Is Reminiscent of Bacterial Apparatus
... G enome delivery and packaging are fundamental processes in the life cycle of a virus. A large genome size (1) coupled with complex replication and assembly (2, 3) processes makes genome packaging in Acanthamoeba ...
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