Nucleoside reverse transcriptase inhibitors (NRTIs)
2D and 3D QSAR of Benzimidazole Analogues as Novel HIV-1 Non Nucleoside Reverse Transcriptase Inhibitors
... of nucleoside/ nucleotide reverse transcriptase inhibi- tors (NRTIs/NTRIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease or entry ...
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Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models
... Gliclazide is a widely used drug for the treatment of type 2 diabetes. Efavirenz and nevirapine are widely used non-nucleoside reverse transcriptase inhibitors for the treatment of HIV ...
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Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... 1(HIV-1) reverse transcriptase codons 41 to 219 in DNA from 127 peripheral blood mononuclear cell samples obtained from 35 patients treated with nucleoside reverse transcriptase ...
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Molecular modeling studies of HIV-1 non-nucleoside reverse transcriptase inhibitors using 3D-QSAR, virtual screening and docking simulations
... (Received 4 September, revised 15 October, accepted 15 November 2018) Abstract: Acquired immunodeficiency syndrome (AIDS) is a significant human health threat around the world and therefore, the study of anti-HIV drug ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... of nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/ NTRIs) and non-nucleoside reverse tran- scriptase inhibitors (NNRTIs), protease inhibitors and HIV ...
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Dolutegravir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Efavirenz Plus Two Nucleoside Reverse Transcriptase Inhibitors As Initial Antiretroviral Therapy for People with HIV: A Systematic Review.
... non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz (EFV) as the preferred regimen in non-pregnant and non-breast- feeding adults [ 14 ...integrase inhibitors and the boosted ...
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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors
... to nucleoside reverse trans- criptase inhibitors ...HIV-1 reverse transcriptase (RT) usually uses an ATP-de- pendent excision pathway to develop resistance to the nucleoside ...
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AZOLES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs): MINI REVIEW
... Two NNRTIs (nevirapine and delavirdine) have been formally licensed for clinical use and several others are (or have been) in preclinical and: or clinical development [tivirapine (TIBO R-86183), loviride (a-APA R89439), ...
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AN INSIGHT TO STRUCTURAL ANALYSIS OF COUMARINS AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
... O O O O OH In order to define ligand-receptor interactions, docking of all the low energy conformations within a range of 5 kcal/mol/Aº from the lowest energy conformation of each molecule, into the cavity of 3HVT, 1IKW, ...
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Bench to bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors
... Abstract Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected ...to reverse NRTI-induced mitochondrial ...
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Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... (HIV-1) reverse tran- scriptase (RT) are associated with resistance to nucleoside analog ...several nucleoside analogs through a complex interaction with other mutations in the RT ...
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Increase in transmitted resistance to non nucleoside reverse transcriptase inhibitors among newly diagnosed HIV 1 infections in Europe
... The NRTI and NNRTI drug classes showed the same significant predictors for resistance in the univariate analyses as was shown for the overall TDRM, although the square root CD4 cell coun[r] ...
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Baseline resistance to nucleoside reverse transcriptase inhibitors fails to predict virologic response to combination therapy in children (PACTG 338)
... Limitations of our study include the fact that we have baseline resistance data on only a subset of children from the entire study and lack of information on adherence to Association bet[r] ...
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Immunogenicity of Mutations Induced by Nucleoside Reverse Transcriptase Inhibitors for Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Cells
... by nucleoside reverse transcriptase (RT) inhibitors (NRTI) on cytotoxic T-lymphocyte (CTL) recognition of human immunodeficiency virus type 1 strain LAI (HIV-1 LAI ) RT was addressed in 35 ...
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Inhibitory activity of 9 phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV 1 as non nucleoside reverse transcriptase inhibitors
... Also similar to NVP, BmPCP inhibits HIV-1 infection by targeting the post entry of the HIV-1 replication cycle by time-of-additional assay. Furthermore, in vitro HIV-1 reverse transcriptase activity assays ...
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Weight gain among treatment-naïve persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.
... Methods: Adult, treatment-na €ıve PWH in NA-ACCORD initiating integrase strand transfer inhibitor (INSTI), protease inhibitor (PI) or non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based ART ...
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Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors
... FDA-approved nucleoside reverse transcriptase inhibitors (NRTIs), HIV-1 specific nonnucleoside (NNRTIs), and protease ...certain nucleoside analogs (NRTIs) with different inhibitory ...
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R5 Variants of Human Immunodeficiency Virus Type 1 Preferentially Infect CD62L− CD4+ T Cells and Are Potentially Resistant to Nucleoside Reverse Transcriptase Inhibitors
... to reverse transcriptase ...the nucleoside reverse tran- scriptase inhibitors (NRTI) zidovudine and lamivudine to stop HIV-1 replication were 20 times greater in activated T cells than ...
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Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice
... the reverse transcriptase inhibitors which did not have such an ...and reverse transcrip- tase inhibitors altered intestinal morphology in vivo, reducing villous height in the duodenum ...
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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and ...
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