nucleotide excision repair (NER)
Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the ...genomic NER, the XPC protein complex ...
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Nucleotide excision repair : a multi-step mechanism required to maintain genome integrity
... multiple repair pathways and various checkpoint signal transduction and effectors systems (hoeijmakers, ...dNa repair. several different dNa repair pathways have been identified which are activated ...
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Nucleotide excision repair deficiency in melanoma in response to UVA
... damage. Repair of UVA-induced DNA damage is thought to occur primarily through the Nucleotide Excision Repair (NER) pathway, which recognises and repairs damage either coupled to ...
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Base flipping in nucleotide excision repair
... several repair mechanisms have evolved to avoid these ...mechanisms, nucleotide excision repair (NER) 2 is characterized by the unique feature that it is able to recognize and ...
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Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... Nucleotide excision repair (NER) is a versatile DNA repair pathway that removes a broad spectrum of DNA lesions that tend to distort the double helix, and is well known for its role in ...
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Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing
... Nucleotide excision repair (NER) is a multistep DNA repair process in which a broad spectrum of DNA lesions are re- moved in two stages - one acting genome-wide (GG-NER) and the ...
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The Mechanism of Nucleotide Excision Repair-Mediated UV-Induced Mutagenesis in Nonproliferating Cells
... functional nucleotide excision repair (NER), but the molecular mechanism of this unique type of mutagenesis has not been further ...in NER-deficient backgrounds and demonstrated that ...
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The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition
... DNA repair pathways, such as single-strand annealing, or in telomere maintenance, its recruitment to DNA lesions is best characterized in the nucleotide excision repair (NER) ...the ...
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Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes
... mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) ...the nucleotide excision repair proteins Rad1p and Rad10p were ...
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The XPC-hHR23b complex and nucleotide excision repair of DNA
... 1996; Buchko et al., 1998) and is essential for its function in NER. Recently, the structure of this dom ain was solved (Buchko et al., 1998; Ikegami et al., 1998). NMR spectra of XPA-DNA complexes suggest that ...
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Nucleotide excision repair in aging & cancer
... essentiële NER‐factoren defect is kan dit leiden tot zeldzame ziektes zoals Xeroderma pigmentosum (XP), Trichothiodystrophy (TTD) of Cockayne syndroom ...essentiële NER‐factoren (XPA en XPC) ...door ...
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Nucleotide excision repair is a predictor of early relapse in pediatric acute lymphoblastic leukemia
... the NER pathway was significantly increased upon relapse in patients that took 3 years or greater to relapse (late relapsers, P = ...the NER gene expression of the early relapsing subpopulation was already ...
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Interactions and function of nucleotide excision repair complexes
... een NER p ro te in ...purified NER proteins from ...e excision repairosom ...1995). NER factors in this com plex w ere id en tified bo th by im m u n o b lo ttin g a n d b y fu n ctio n al com ...
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Gastroesophageal junction adenocarcinoma displays abnormalities in homologous recombination and nucleotide excision repair
... (DNA) repair has been a major player in cancer sensitivity to these ...DNA repair defects have been described in various ...DNA repair are present in EAC compared with normal gastroesophageal ...
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<em>ERCC1</em> rs3212986 A/C polymorphism is not associated with chemotherapy treatment outcomes in gastric cancer patients: evidence from 11 publications in Chinese populations
... DNA repair systems play an important role in repairing the damage to DNA induced by endogenous and/or exogenous factors such as therapeutic ...agents. Nucleotide excision repair (NER) ...
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<em>ERCC1 </em>and <em>XRCC1 </em>as biomarkers for lung and head and neck cancer
... for nucleotide excision repair (NeR) of bulky chemical DNA adducts like cisplatin intrastrand crosslinks, the repair of double-strand breaks that cannot be directly ligated back ...
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Original Article Association of NER pathway gene polymorphisms with susceptibility to laryngeal cancer in a Chinese population
... Larynx cancer is an important entity of cancer, which accounts for 30%-40% of all malignant head and neck tumors [1, 2]. It is estimated that the there were 138,102 new cases with laryngeal cancer and 73,261 deaths from ...
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Mechanisms of interstrand DNA crosslink repair and human disorders
... ICL repair is exceptionally challenging because an ICL lesion affects both DNA ...various excision repair pathways, including nucleotide excision repair (NER), base ...
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Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to Squamous Cell Carcinomas of the Head and Neck (SCCHN) and Breast cancer in the north Indian population
... the Nucleotide excision repair (NER) pathway, a major DNA repair pathway that removes photoproducts from UV radiation and bulky adducts from a huge number of chemicals, cross-links and ...
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DNA damage repair in ovarian cancer: unlocking the heterogeneity
... Nucleotide excision repair (NER) is a highly conserved and versatile pathway used to remove ‘bulky lesions’ caused by UV light and carcinogens such as benzopyr- ene, which would otherwise ...
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