Nude Mice
Human Cancer Xenografts in Outbred Nude Mice Can Be Confounded by Polymorphisms in a Modifier of Tumorigenesis
... The mechanism by which the phospholipase 2A enzyme Pla2g2a decreases intestinal tumor burden in resistant strains is not completely understood. Pla2g2a is expressed in Paneth cells in the small intestine and goblet cells ...
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MMP-12-mediated by SARM-TRIF signaling pathway contributes to IFN-γ-independent airway inflammation and AHR post RSV infection in nude mice
... determined. Nude mice are congenitally deficient in T cells, but their innate immunity is normal or compensato- rily enhanced ...in nude mice, but unex- pectedly, IFN-γ showed no perceivable ...
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Stromelysin 3 expression promotes tumor take in nude mice
... of mice did not re- veal any lung or liver metastases, even after pS2 immunostain- ing allowing the detection of isolated MCF7 cells ...in nude mice after in- jections of either parental MCF7 cells ...
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Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice
... Background: Advanced hepatocellular carcinoma (HCC) patients undergo significant tumor growth and metastasis. Here, we investigated bufalin for treating HCC, which exhibits anti-tumor activities in many tumor cell lines. ...
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RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice
... in nude mice; and (5) Abs raised against RAGE inhibited the lung metastasis of G361 melanoma and resultantly pro- longed the survival of tumor-bearing immunoincompetent mice ...in nude ...
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Characteristics of Viruses Derived from Nude Mice with Persistent Measles Virus Infection
... In addition to mutations in MV, it is believed that the immune state of the host is also associated with the onset of SSPE (1). MV infection in young children, such as those less than 1 year old, is a risk factor for ...
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Original Article Homing of SPIO-MSCs to liver metastasis in nude mice
... the nude mouse xenograft, respectively. On the 9th day after injection, nude mice were anesthetized by ether and placed within ...9 nude mouse models were scanned and MRI images were ...
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Experimental infection of Balb/c nude mice with Hepatitis E virus
... HEV antigens were observed by indirect immunofluores- cence in liver, spleen, kidney, jejunum, ileum and colon in the inoculated group on days 4 and 7, and in one of member of contact-exposed group on day 7 using appro- ...
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<p>Effect of Th9/IL-9 on the growth of gastric cancer in nude mice</p>
... BALB/c nude mice were randomly divided into three groups: a normal control group (Control), an SGC-7901 xenografted nude mice model group (Model), and a rIL-9 treatment group ...
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New fat-derived products for treating skin-induced lesions of scleroderma in nude mice
... Scleroderma is a chronic systemic autoimmune disease primarily of the skin (‘derma’) characterized by fibrosis or hardening (‘sclero’), vascular alterations, and autoanti- bodies [25,26]. Various cutaneous manifestations ...
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Theiler's virus infection in nude mice: viral RNA in vascular endothelial cells.
... Besides the presence of viral antigen in these cell types, by in situ hybridization, Theiler's virus RNA was also found in cells associated with vascular endothelium in the brains and sp[r] ...
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Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90 Y-labeled anti-α
... tumor growth in comparison with the control groups. We expected that double administrations will be more potent than single administration, but no significant difference was observed (Figure 1). We examined the potential ...
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Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice.
... The amount of the Eli^E4 mRNA species a can be deduced from the difference between the cytoplasmic signals generated from the E4-E5 probe and those specific for the other E region messag[r] ...
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Pharmacologic control of a humanized gene therapy system implanted into nude mice
... Systemic delivery of specific therapeutic proteins by a parenteral route of administration is a recognized practice in the management of several gene defects and acquired dis- eases. As an alternative to repetitive ...
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Restricted virus replication in the spinal cords of nude mice infected with a Theiler's virus variant.
... By 6 weeks after per os infection, the distribution of virus-infected cells within brain and spinal cord was essentially the same in wild-type DA virus-infected and variantvirus-infected[r] ...
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Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPARγ
... been different hypotheses on how the androgen-dependent cells transform into androgen-independent cells. The main theory to date is that the biological sensitivity of AR is selectively amplified after the first round of ...
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A novel long-sustaining system of apatinib for long-term inhibition of the proliferation of hepatocellular carcinoma cells
... preparation of the insoluble apatinib into a stable aqueous solution, which also facilitates the pharmaceutical prepara- tion of apatinib. Application of Apa-Cyc in clinical treat- ment could also avoid the potential ...
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Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo
... when nude mice and BALB/c mice were pre-injected with nanogram levels of a synthetic Zfra1–31 or truncated Zfra4–10 peptide via tail veins, these mice became resistant to the growth, ...
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Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer
... male nude mice bearing subcutaneous Ki-ras cell tumors (vol ~ 50 mm 3 ) were randomized into five groups of ...seven. Mice model groups received different treatments with free CRAds or Adbic and ...
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Original Article Effects of lentiviral-mediated Wnt5a overexpression on biological functions of hepatoma cells and expression of Gli1 transcription factor
... The nude mouse tumorigenesis experiment indirectly reflected the effect of Wnt5a on ...the nude mice infected with Wnt5a-overexpressing cells was significantly lower than that in the control group, ...
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