O glcnacylation
Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis
... which O-GlcNAcylation promotes CD36 production can be attributed to enhanced transcription of ...Elevated O-GlcNAcylation is known to activate several signal transduction pathways in ...of ...
15
Glucose regulates tissue-specific chondro-osteogenic differentiation of human cartilage endplate stem cells via O-GlcNAcylation of Sox9 and Runx2
... Glucose is the critical energy supply and metabolite for most cells and is especially the key for cell differentiation. To evaluate the influence of glucose on chondrogenic dif- ferentiation and osteogenic ...
13
O -GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity
... of O-GlcNAcylation on ATG4B. In order to evaluate the function of O-GlcNAcylated ATG4B, we employed an assay system which had already been validated for ATG4B ...that O-GlcNAcylation of ...
11
O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis
... and O-GlcNAcylation (Supplemental ...of O-GlcNAcy- lation in regulating GA signaling came from the identi- fication of a putative O-linked N-acetylglucosamine (O-GlcNAc) transferase ...
14
Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling
... increased O-GlcNAc levels has been reported. O-GlcNAcylation of RelA/p65, a subunit of NF-κB, is critical for activation of NF-κB signaling in mesangial cells and T- and B-lymphocytes [21, ...is ...
14
H2A O -GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX
... several O-GlcNAcylated sites on the serine or threonine of core histones have been reported ...Recently, O-GlcNAcylation on H2AX at Ser139 (S139) was found in DNA damage foci ...the ...
14
Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation
... Protein O-GlcNAcylation has attracted increasing attention in recent years, with the recognition that it can modify the function of numerous cellular proteins both under physiological and pathological ...
17
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
... that O -GlcNAcylation of miro and milton (OIP106 and GRIF-1) plays a crucial role in the transportation of vesicles and mitochondria via microtubules ...the O- GlcNAcylation of a-tubulin was ...
16
Suppressive Regulation of KSHV RTA with O-GlcNAcylation
... Thr-367 O -GlcNAc mutants associated with less PARP1 (Figure 5) and were more potent (Figure ...hypo- O -GlcNAcylation is a favorable environment for KSHV lytic cycle ...the ...
13
TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer
... had rarely detectable TAB3 (Figure S1A). To investigate whether the expression of TAB3 was associated with breast cancer cell migration and invasion, stable MDA-MB-231 or MDA-MB-468 cells transfected with TAB3 expression ...
12
O GlcNAcylation is required for mutant KRAS induced lung tumorigenesis
... increased O-GlcNAcylation was recently observed in A549 cells (45), but the functional significance for this EMT-HBP axis for tumorigenesis and tumor maintenance was not ...protein ...
15
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
... that O-GlcNAc and OGT levels were increased in all six gastric cancer (GC) cell lines as compared with immortal gastric epithelial ...the O-GlcNAcylation level by silencing OGT inhibited cell ...
13
Exploring the Potential of -Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging
... its O-GlcNAcylated form based on intramolecular Förster resonance energy transfer (FRET) technology in ...the O-GlcNAcylation status of -catenin in HeLa ...in O-GlcNAcylation of ...
14
Discovering Biological Roles of Glycosaminoglycans and Protein O GlcNAcylation Using Chemical Tools
... O-GlcNAcylated proteins. 6-8, 13 However, each suffers from significant drawbacks for site identification. For example, a photocleavable linker (alkyne- PC-biotin 5-1, Figure 5-2) was employed in conjunction with ...
245
O-Linked N-Acetylglucosaminylation of Sp1 Inhibits the Human Immunodeficiency Virus Type 1 Promoter
... by O-GlcNAc- ylation of Sp1. This indicates that O-GlcNAcylation of Sp1 inhibits the activity of the HIV-1 LTR in a dominant ...of O-GlcNAcylated Sp1 on the HIV-1 LTR relies on the ability of ...
15
<em>O</em>-GlcNAcylation enhances the invasion of thyroid anaplastic cancer cells partially by PI3K/Akt1 pathway
... up-regulated O-GlcNAcylation were constructed, and then cell proliferation and invasion were ...elevated O-GlcNAcylation by mediating phosphorylation at ...
9
Identification of Secret Agent as the O-GlcNAc Transferase That Participates in Plum Pox Virus Infection
... that O-GlcNAc modification by SEC OGT is not essential for PPV viability in ...tion. O-GlcNAc modifications at the segment from amino ac- ids 1 through 39 of PPV CP are not essential, since deletions or ...
7
O-β-GlcNAcylation, Chloroquine and 2-Hydroxybenzohydrazine may hamper SARS-CoV-2 entry to human via inhibition of ACE2 phosphorylation at Ser787 but also induce disruption of virus-ACE2 binding
... and O-GlcNAcylation as docking ligands, and we found that these compounds might inhibit the ACE2 phosphorylation and suppressing the interaction of coronavirus spike glycoprotein with human ...
34
Glycomic Approaches to Study GlcNAcylation: Protein Identification, Site-mapping, and Site-specific O-GlcNAc Quantitation
... Protein GlcNAcylation is distinct from classical “mucin-type” ...First, O-linked β-N-acetylglucosamine (O-GlcNAc) is found only on nuclear and cytoplasmic proteins, and not on secreted or cell ...
9
Gigaxonin glycosylation regulates intermediate filament turnover and may impact giant axonal neuropathy etiology or treatment
... Because gigaxonin and CUL3 interact genetically and biochemically, we hypothesized that loss of gigaxonin O-GlcNAcylation at specific sites might affect these functional interactions, by analogy with our ...
22