ODC, ornithine decarboxylase
IN VITRO ANALYSIS OF ORNITHINE DECARBOXYLASE INHIBITORY ACTIVITY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L
... of ornithine remained almost equal in the samples before inoculating the media with ...of ornithine started depleting steadily in all ...and ornithine was used up by the enzyme produced by ...of ...
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RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes in Trypanosoma brucei Provides Insight into Regulation of Polyamine Biosynthesis
... that ODC knock- down is not rescued by spermidine was that elevated AdoMet and dcAdoMet levels contribute to cell death when ODC is inhibited or depleted from the ...of ODC, and 40- fold by DFMO ...
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Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes
... increased ODC activity ...chronic ODC blockade also mitigates the charac- teristic increases in proximal reabsorption and GFR in rats with diabetes, while bearing no significant effect on glomerular ...
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P Elements Inserted in the Vicinity of or Within the Drosophila snRNP SmD3 Gene Nested in the First Intron of the Ornithine Decarboxylase Antizyme Gene Affect Only the Expression of SmD3
... of ODC half-life is mediated by AZ (Hayashi 1989; peded by the difficulty of assigning mutations to these Hayashi et ...to ODC, inhibits its genes and identifying their ...the ornithine ...
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Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice
... cutaneous ornithine decarboxylase (ODC), the first enzyme in the polyamine-biosynthesis pathway, which drives continued proliferation and clonal expansion of initiated (mutated) cells, leading to ...
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Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
... by ornithine decarboxylase (ODC) modulate eIF-5A which is a direct regulator of the LIN28/Let-7 ...inhibiting ODC will restore balance to the LIN28/Let-7 axis, suppress glycolytic metabolism, ...
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Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor
... or ODC, AZI and ...for ODC and AZI (Figure ...of ODC for AZ (Table ...with ODC, followed by treatment with CCND1 ([AZ+ODC]+CCND1, green line, Figure 4A); the second set involved ...
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The Inhibitory Effect of Curcumin on Ornithine Decarboxylase against Hepatic Carcinoma
... RT-qPCR for each target gene (ODC gene, P53 gene, Bcl-2 gene, Bax gene, cas- pase-3 gene and the housekeeping gene (GAPDH)) was performed in a 25 µL which contains the following: 3 µL cDNA template (10 - 20 ...
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The malignant phenotype in breast cancer is driven by eIF4A1 mediated changes in the translational landscape
... eIF4E is a well-established oncogene,10,11 and the translation of several oncogenic mRNAs with long or structured 5′UTRs, such as c-myc, cyclin D1 and ornithine decarboxylase ODC were sh[r] ...
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Endogenous ornithine decarboxylase/polyamine system mediated the antagonist role of insulin/PEG-CMCS preconditioning against heart ischemia/reperfusion injury in diabetes mellitus
... found that ODC expression, Sp, total PAs reduced and Pu increased on HI/RI in DM. We speculated that Pu in the total PAs was relatively low, and 70% of its content in cells was related to catabolism of polyamine. ...
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Cloning, expression and characterization of the ornithine decarboxylase gene from Dictyostelium discoideum
... Fig. 2. Dictyostelium discoideum orni- thine decarboxylase (DdODC) shares sequence homology with known ODC proteins. Neighbor joining (NJ) phyloge- netic trees with 1000 bootstrap replicates to create a ...
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General Symmetric Starter of Orthogonal Double Covers of Complete Bipartite Graph
... If all pages in Ᏻ are isomorphic to a graph G, then Ᏻ is said to be an ODC by G. Clearly, G must have exactly n − 1 edges. The existence of ODCs was considered by many authors [1–9]. Although progress on the ...
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L Ornithine nitrate
... the ornithine forms strong NÐ H O hydrogen bonds with the carboxyl and nitrate groups (Table ...The ornithine residue is involved in both zigzag (Z2) and straight (S2) head-to-tail ...
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The Challenge of Delivering Impact: Making Waves Through the ODC Debate
... Third, for energising to happen, it requires difference as well as similarity. This seemingly paradoxical position entails both scholars and organizational practitioners sharing a joint background through which they can ...
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The Challenge of Delivering Impact: Making Waves Through the ODC Debate
... The crisis narrative told by some members of the organization as well as the control narrative narrated by clients are only meaningful in relation to the dominating customer intimacy nar[r] ...
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Effects of the sap of the common oleander Nerium indicum (Apocyanaceae) on male fertility and spermatogenesis in the oriental tobacco budworm Helicoverpa assulta (Lepidoptera, Noctuidae)
... We investigated the effects of sap of the common oleander Nerium indicum (Apocyanaceae) on male fertility and spermatogenesis in the oriental tobacco budworm Helicoverpa assulta. We found that continuous feeding of ...
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Vol 70, No 4 (2018)
... proliferation, ornithine decarboxylase 1 (ODC1) and adenosine deaminase (ADA) gene expression in human breast cancer cell line (MCF-7) as compared to the non-cancer line ...
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Regulation of Adrenal Ornithine Decarboxylase by Adrenocorticotropic Hormone and Cyclic AMP
... observed 4 h after administration of these substances. Effects of ACTH and dibutyryl cyclic AMP were not secondary to stimulation of steroidogenesis, since hydrocortisone had no effect on adrenal ornithine ...
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Bile salt stimulation of colonic epithelial proliferation Evidence for involvement of lipoxygenase products
... mucosal ornithine decarboxylase activity (4 h), and a subsequent two to threefold increase in [3H]thymidine [( 3H]Thd) incorporation into DNA of either mucosal scrapings or isolated pools of proliferative ...
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Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants
... suppressible by chronic alkali therapy. Stimulation of renal growth could not be ascribed to increased intrarenal iron, induction of ornithine decarboxylase, or alterations in glomerular hemodynamics. ...
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