ODN, oligodeoxynucleotide
Studies towards oligodeoxynucleotide conjugates as potential photoactive antisense agents in chronic myeloid leukaemia
... an ODN model of the bcr/abl oncogenic mRNA present in chronic myeloid leukaemia ...CML. ODN conjugates were synthesised with photosensitising molecules, which were derivatives of a ruthenium polypyridyl ...
195
A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice
... CpG oligodeoxynucleotides (CpG ODNs) are short synthetic single-stranded DNA molecules containing unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs). CpG ODNs can trigger cells that express ...
8
Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo
... Several previous reports demonstrated that E2F-Rb com- plex repressed transcription upon binding to certain E2F- responsive promoters (58, 59). The binding of Rb to E2F is controlled by phosphorylation of Rb, and the ...
10
Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma
... Background: Neuroblastoma is a pediatric cancer of neural crest origin. Despite aggressive treatment, mortality remains at 40 % for patients with high-risk disseminated disease, underscoring the need to test new ...
11
CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies
... of IL-12p40 and TNF- α . The levels of costimulatory molecules and cytokines induced from BMDCs by the self-ligated X-DNA complex were significantly higher than those induced by a nonself-ligated single X-DNA unit. This ...
17
<p><em>N</em>-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis</p>
... c oligodeoxynucleotide (ODN) sequences can inhibit in fl ammation and reduce alveo- lar bone ...5,6 ODN can be classi fi ed into stimulatory ODN, inhibitory ODN, and inert ...Stimulatory ...
9
Toll like receptor 9–induced type I IFN protects mice from experimental colitis
... sequence oligodeoxynucleotide (ISS-ODN, also known as CpG- ODN) contain unmethylated CpG dinucleotide motifs within consensus sequences and are ligands of Toll-like receptor 9 (TLR9) ...
9
Heme oxygenase 1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats
... HO-1 oligodeoxynucleotide (ODN) significantly delayed the clearance of oxyhemoglobin and deoxyhemoglobin from the subarachnoid space and aggravated angiographic ...HO-1 ODN inhibited HO-1 induction ...
9
Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood stage malaria in mice
... Development of a vaccine that targets blood-stage malaria parasites is imperative if we are to sustainably reduce the morbidity and mortality caused by this infection. Such a vaccine should elicit long-lasting immune ...
13
CD8+ T-Cell-Mediated Cross-Clade Protection in the Genital Tract following Intranasal Immunization with Inactivated Human Immunodeficiency Virus Antigen Plus CpG Oligodeoxynucleotides
... CpG oligodeoxynucleotide (ODN) as an adjuvant induced local immune responses in the genital tract and cross-clade protection against intravaginal (IVAG) ...
8
Phenotypic and functional abnormalities of bone marrow derived dendritic cells in systemic lupus erythematosus
... μmol/L oligodeoxynucleotide [ODN] containing unmethylated CpG motifs(CpG ODN)2006 and 2 μmol/L CpG ODN 2216 (InvivoGen, San Diego, CA, USA), 50 ng/ml tumor necrosis factor (TNF)-α ...
12
Original Article Toll-like receptor 9 inactivation ameliorates ox-LDL injured HUVEC activity in vitro
... Abstract: Background: Inflammatory responses that are induced by oxidized low density lipoprotein (ox-LDL) play substantial functions in atherogenesis, and could be elevated in diabetic patients. Toll-like receptor 9 ...
8
Epstein-Barr virus RNA. V. Viral RNA in a restringently infected, growth-transformed cell line.
... Hybridization of nuclear, polyadenylated, polyribosomal RNA cDNA-P templates by use of oligodeoxynucleotide primers was hybridized or polyribosomal RNAs from IB-4 with denatured to blots[r] ...
13
Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor
... Distributed under a Creative Commons CC BY license..[r] ...
12
32P Oligodeoxynucleotide Coated Coils to Prevent Arterial Recanalization after Embolization
... With this study, we showed in vitro and in vivo that the 32P-oligodeoxynucleotide binds tightly to the platinum coil, and that 32P 15-mer oligonucleotide coils led to permanent occlusion[r] ...
5
Species specific oligodeoxynucleotide probes for the identification of periodontal bacteria
... To determine whether or not the synthetic probes were specific for the appropriate microbe, each probe was tested against a panel of total nucleic acids isolated from 20 microorganisms c[r] ...
5
Minus-strand copies of replicating coronavirus mRNAs contain antileaders.
... An oligodeoxynucleotide with a sequence from within the leader was used as a probe in Northern analysis on RNA from infected cells, and an antileader a minus-strand copy of the leader se[r] ...
6
Antisense oligodeoxynucleotide to the cystic fibrosis transmembrane conductance regulator inhibits cyclic AMP activated but not calcium activated cell volume reduction in a human pancreatic duct cell line
... Rapid Publication Antisense Oligodeoxynucleotide to the Cystic Fibrosis Transmembrane Conductance Regulator Inhibits Cyclic AMP-activated but not Calcium-activated Cell Volume Reduction [r] ...
6
Detection of Mycoplasma hyopneumoniae by using rRNA oligodeoxynucleotide hybridization
... hyopneumoniae in clinical samples, such as bronchoalveolar lavage fluid and lung lesions from experimentally infected pigs, was evaluated by this assay.. The evidence obtained from the a[r] ...
6
Bock, Carmen Maria (2004): CpG-DNA fördert die Bildung von multinukleären Riesenzellen mit Resistenz gegen intrazelluläre Leishmanieninfektion. Dissertation, LMU München: Medizinische Fakultät
... stimulatorische Funktion von plasmazytoiden dendritischen Zellen. Dendritische Zellen, die aus Monozyten in der Gegenwart von GM-CSF und Interleukin-4 generiert wurden, werden durch CpG-ODN 2006 nicht zur ...
92