oestrogen-receptor
Advances in the treatment of advanced oestrogen-receptor-positive breast cancer.
... Oestrogen receptor (ER) positive breast cancer is the most common subtype of breast cancer. Endocrine therapies that target the dependence of this subtype on ER have substantial activity, yet resistance to ...
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The oestrogen receptor gene (ESR) PvuII polymorphism allele frequencies in Czech Large White and Landrace
... Genotype and allele frequencies of the oestrogen receptor gene (ESR) PvuII restriction site were inves- tigated in populations of the main Czech maternal breeds. 1253 sows and gilts and 396 boars in Large ...
6
The role of ligand in oestrogen receptor dimerisation and DNA binding
... the oestrogen, glucocorticoid and progesterone receptors and it has been suggested that this protein may stabilise the interactions of steroid receptors with their response elements leading to the formation of a ...
232
In silico discovery and validation of potent small molecule inhibitors targeting the activation function 2 site of human oestrogen receptor α
... Luciferase oestrogen receptor-alpha transcriptional assay ERα-positive T47D-KBluc human BCa cells were grown in phenol red–free RPMI 1640 supplemented with 10% CSS for 5 ...
17
Transcriptional activation and dimerisation properties of oestrogen receptor β
... The oestrogen receptor (ER) is a m em ber of the nuclear receptor superfam ily of ligand inducible transcription ...of oestrogen the ER exists in the cell as p a rt of an inactive complex w ...
193
Hypersensitive K303R oestrogen receptor α variant not found in invasive carcinomas
... Most breast cancers overexpress oestrogen receptor-α (ER-α), and this molecule is the major target of the anti- estrogens, such as tamoxifen, used to treat the disease. Not all patients respond to ...
6
Oestrogen receptor negative breast cancers exhibit high cytokine content
... inversely correlated to oestrogen receptor and progesterone receptor status. Most cytokines were not correlated with age at cancer diagnosis, tumour size, histological type, or lymph node status. ...
11
Secondary Metabolites in Flax Root Extracts at Various Stages of Maturity and Effects on Proliferation and Cytotoxicity in Oestrogen Receptor Positive Breast Cancer Cells
... Flax contains large amounts of hormone-like compounds, especially lignans. These so-called phy- toestrogens are thought to inhibit the cell growth of hormone-sensitive cancers. Hence, we ana- lysed the influence of flax ...
7
Transcriptional activation by the mouse oestrogen receptor
... wild-type receptor the removal of the N-terminus (in the mutant MOR 121-599) had no significant effect on the ability of the oestrogen receptor to stimulate transcription from pERE BLCAT whilst it ...
216
Oestrogen Receptor Status of Breast Tumour Biopsies in Malaysian Patients
... Oestrogen Receptor Status of Breast Tumour Biopsies in Malaysian Patients Med J Malaysia VoI 38 No 2 June 1983 STATUS OF BREAST MALAYSIAN PATIENTS OESTROGEN RECEPTOR TUMOUR BIOPSIES IN SHAHARUDDIN AZI[.] ...
5
Oestrogen receptor β (ERβ) regulates osteogenic differentiation of human dental pulp cells
... press oestrogen receptor (ER) isoforms ER , ER 1 and ER 2, as well as a 7-transmembrane G protein-coupled receptor, GPR30, that mediates rapid oestrogen signalling ...main receptor ...
24
Molecular mechanism of transcriptional activation by oestrogen receptor alpha
... mutant receptor respond to both Tamoxifen and Raloxifene as agonist suggesting that this may be one mechanism for the development o f Tam oxifen resistance in breast tumours (Levenson and Jordan, ...
253
The role of the oestrogen receptor in antioestrogen resistant breast cancer
... Chicken embryo fibroblasts were transfected and harvested as described in fig legend 5.7 This figure shows data from an experiment in which cells are incubated with bot[r] ...
203
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling
... activation of the EGFR [6] and downstream phosphory- lation of ERK [20]. We, therefore, measured activation of ERK signalling by ER and assessed the effect of the specific EGFR inhibitor gefitinib. Activation of ER sig- ...
12
Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
... on oestrogen for growth. In standard medium without added oestrogen, growth is strongly ...[16]. Oestrogen-induced cell proliferation is mediated by the transcription activation function of the ...of ...
11
Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1
... rapid oestrogen sig- nalling, and it is likely that further complexity in oestrogen- mediated GPCR signalling may occur as a result of coupling of different G protein heterodimers with the same ...II ...
10
Oestrogen receptor alpha in pulmonary hypertension
... that oestrogen may mediate proliferation of hPASMCs and may contribute to PAH ...that oestrogen can induce proliferation of hPASMCs via ERa ...the receptor that mediates estrogen- induced ...
11
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.
... (b) On the combined set from Phase I and Phase II the Ki67 level of poor responders was signi cantly higher for patients with mutated TP53 (mut) than wild-type TP53 (WT). This was not [r] ...
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Review: Predictive and Prognostic Features and Their Impact on Outcome for Early-stage Breast Cancer in Mid-Western Ireland
... In this paper, we herein report on the predictive and prognostic factors in female patients with EBC including: axillary nodal status, tumour size, tumour histological type/grade, age at presentation and oestrogen ...
16
Understanding the mechanisms of aromatase inhibitor resistance
... with oestrogen receptor (ER)-positive advanced breast cancer reported that patients who received the combination therapy experienced signifi - cantly longer progression-free survival (PFS) and an improvement ...
11