oncogenic pathways
Genome and transcriptome delineation of two major oncogenic pathways governing invasive ductal breast cancer development
... Several attempts have been made to identify the molecular mechanisms underlying the morphological characteristics of HG to improve its objectivity [1, 5, 6, 8, 17–19]. The continuous progressive model of tumor ...
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Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways
... aforementioned oncogenic pathways and generating cancer stem-like cells (as shown in our study) while generating M2 TAMs via increased M2-polarizing IL-4 and IL-13 cytokines into the stroma ...
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Whole-genome sequencing of multiple myeloma reveals oncogenic pathways are targeted somatically through multiple mechanisms.
... in oncogenic pathways, we extended our analysis identifying coding drivers in 40 genes, including 11 novel ...same pathways can be targeted by coding and non-coding mutations; exempli fi ed by IRF4 ...
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Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.
... the pathways that were exclusively affected by splicing ...for pathways involving cell surface and extracellular matrix genes, controlling cellular adhesion, cellular motility and ...key oncogenic ...
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Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN
... LIM-homeodomain transcription factor ISL1 is expressed in sympathetic neurons immediately after their differentiation and plays a crucial role in sympathetic neuron development [27]. ISL1 directly or indirectly regulates ...
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Cdh1 functions as an oncogene by inducing self-renewal of lung cancer stem-like cells via oncogenic pathways
... predict pathways likely mediating the oncogenic function of Cdh1 carries in lung adenocarcinoma (Figure ...the oncogenic receptor tyrosine kinase-MAPK and PI-3K signaling ...characterized ...
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Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma
... The study of survival outliers of glioblastoma can provide important clues on gliomagenesis as well as on the ways to alter clinical course of this almost uniformly lethal cancer type. However, there has been little ...
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Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model specific signalling networks and conserved oncogenic pathways
... for pathways associated with cytoskeletal organisation, in concordance with the observed mutational spectrum reported for triple-negative breast cancers ...
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Wnt/β catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
... known oncogenic pathway that plays a well-defined role in colon and skin cancer; however, its role in lung cancer is ...other oncogenic pathways in lung epithelium to produce a more aggressive tumor ...
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Identification of COX5B as a novel biomarker in high-grade glioma patients
... In this study, we used bioinformatics to detail the global program of gene expression in different-grade glioma tissues and to try to identify some genes associated with the tumorigenesis of gliomas. We found that 3,726 ...
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Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes
... signaling pathways for their impact on oncogenic properties, with a specific focus on drug ...signaling pathways that had been previously found to be frequent players in oncogenic processes ...
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Review Article Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions
... relevant oncogenic pathways has in turn led to the development of targeted therapies, including, recently, small molecules targeting key complexes involving the oncogenic fusion ...rent ...
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Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA- approved compounds
... of oncogenic signalling pathways represents the main goal of modern oncology: selective inhibitors of oncogenes such as mutated kinases have been identified mainly through traditional small molecule drug ...
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Splicing dysregulation as a driver of breast cancer.
... Gracio F, Burford B, Gazinska P, Mera A, Mohd Noor A, Marra P, Gillett C, Grigoriadis A, Pinder S, Tutt A, et al. 2017 Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and ...
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Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
... Identification of Slug as a key effector of cyclin D1b function provides a substantial advance in understanding aggressive cyclin D1b–induced tumor phenotypes and provides strong evidence linking 2 major oncogenic ...
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Oncogenic Human T-Cell Lymphotropic Virus Type 1 Tax Suppression of Primary Innate Immune Signaling Pathways
... TLR pathways, as well as RIG-I/ MDA5-dependent TLR-independent pathways and the recently discovered STING pathway essential for DNA-mediated innate signaling (35, ...B pathways were not suppressed ...
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CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc
... its oncogenic effect in part through the upregulation and activation of TERT and ...critical oncogenic roles of the CUDR in liver cancer stem cells, liver stem cells and supported the notion that CUDR may ...
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Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer
... Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral T[.] ...
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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras
... which oncogenic Ras-expressing cells acquire the nutrients necessary to support cell growth and survival ...that oncogenic Ras-expressing cells are highly sensitivity to nutrient deprivation ...harboring ...
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Modeling breast cancer progression to bone: how driver mutation order and metabolism matter
... of pathways involved in the production of cytomembrane proteins which induce new pro-oncogenic behaviours; they increase the capabil- ity of cancer cells to ...
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