Oncolytic Virus
Oncolytic virus immunotherapy: future prospects for oncology
... approved oncolytic viral ther- apy is talimogene laherparepvec (T-Vec or Imlygic) for use in metastatic melanoma, though there are numerous other viruses being developed pre-clinically and clinic- ...of ...
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Mathematical Modeling and Analysis of Tumor Therapy with Oncolytic Virus
... that oncolytic viruses enter tumor cells and ...with oncolytic viruses, further cause infection in other tumor ...cells. Oncolytic virus preferentially infects and lysis cancer cells both by ...
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Deficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1
... the oncolytic effects of M1 virus in ...M1 virus infection via induction of autophagy signaling, we predicted that blocking IRE1 ␣ -autophagy signaling would in- crease the viral protein load and the ...
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Ultrasound-mediated oncolytic virus delivery and uptake for increased therapeutic efficacy: state of art
... and oncolytic viruses. Oncolytic viruses can selectively replicate within and destroy a cancer cell, thus making them a powerful therapeutic in treating late-stage or metastatic ...in oncolytic ...
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<p>Virus–Receptor Interactions and Virus Neutralization: Insights for Oncolytic Virus Development</p>
... Most oncolytic viruses exert anti-tumor activity by penetrat- ing the tumor cells, establishing a lytic cycle and ultimately causing the activation of cell death ...for oncolytic viral entry are expressed ...
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<p>Virus–Receptor Interactions: Structural Insights For Oncolytic Virus Development</p>
... is released into the nucleus. 35 Evidence from various clinical studies points toward a direct relationship between the expres- sion of HSV receptors in tumors, cancer progression and prognosis. For instance, herpesvirus ...
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High-throughput screening to enhance oncolytic virus immunotherapy
... dent genome-wide screens with a siRNA library targeting 18,120 genes across three distinct tumor cell lines to identify host genes that mediated MRB virus-induced oncolysis. We observed 1,008 synthetic lethal hits ...
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Oncolytic Virus Therapy for the Treatment of Metastatic Ovarian Cancer
... Viral oncolytic therapy cannot be regarded as a universally efficacious treatment for cancer, but rather a broad strategic category of therapies that have vastly different impacts on the cells they infect, the ...
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Oncolytic virus delivery: from nano-pharmacodynamics to enhanced oncolytic effect
... Therapeutic safety of vectors is proportional to their tumor target selectiveness. Selective targeting using tumor-specific promoters ensures that viral replication will be restricted to cancerous tissues while healthy ...
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Oncolytic virus therapy for cancer
... Vaccinia virus is a member of the poxvirus family and exists as an enveloped viral particle that contains a linear double- stranded DNA ...the virus evade immune detection. Vaccinia virus naturally ...
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Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy.
... The anti-tumor effects associated with oncolytic virus therapy are mediated significantly 29.. through immune-mediated mechanisms which depends both on the type of v[r] ...
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Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
... stomatitis virus safety in the ...an oncolytic virus or as a vaccine vector against more dangerous viruses, including Ebola virus (34), HIV, and other pathogenic viruses, has been the con- ...
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The ex vivo purge of cancer cells using oncolytic viruses: recent advances and clinical implications
... involving oncolytic virus strains of adenovirus, herpes simplex virus type 1, myxoma virus, and reovirus as ex vivo purging agents for HSC grafts, as well as in vitro and in vivo experimental ...
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Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs
... Histone deacetylase inhibitors (HDIs) are a class of com- pounds that appear to benefit HSV oncolysis, possibly via suppression of innate immune responses. Histone deacety- lases (HDACs) have pleiotropic effects on cells ...
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Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
... measles virus have used the attenuated vaccine Edmonston strain, which is derived from the common wild-type measles virus and is observed to have minimal side ...Measles virus is chiefly based on the ...
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Coronavirus Genetically Redirected to the Epidermal Growth Factor Receptor Exhibits Effective Antitumor Activity against a Malignant Glioblastoma
... candidate oncolytic virus in ...the virus retained its ability to induce cell-cell fusion and produce progeny ...recombinant virus mediated efficient cell killing of the human glioblastoma ...
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A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1
... Oncolytic virotherapy is an emerging and promising treatment modality that uses replicating viruses as selective antitumor agents. Here, we report that a classical protein kinase A (PKA) inhibitor, H89, synergizes ...
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Advances in the design and development of oncolytic measles viruses
... successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding ...tissue. Oncolytic measles virus (MV) ...
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Proof-of-principle that a decoy virus protects oncolytic measles virus against neutralizing antibodies
... decoy virus in protecting oncolytic virus from neutralization leading to decreased viability of Jurkat cells was determined after 96 ...decoy virus given. However, the decoy virus, even ...
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<p>Oncolytic viro-chemotherapy exhibits antitumor effect in laryngeal squamous cell carcinoma cells and mouse xenografts</p>
... ZD55-EGFP virus infection, which is an oncolytic virus carrying EGFP ...of virus infection, it is necessary to evaluate the toxicity of ZD55-TRAIL and chemothera- peutic agent on normal ...
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