oncolytic viruses
Tune Up In Situ Autovaccination against Solid Tumors with Oncolytic Viruses
... Oncolytic viruses have also been engineered to encode antibodies against immune checkpoint ...the viruses were equally efficient as parental MV in oncolytic efficacy against human tumors ...an ...
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Non Linear Mathematical Model of the Interaction between Tumor and Oncolytic Viruses
... A mathematical modeling of tumor therapy with oncolytic viruses is discussed. The model consists of two coupled, de- terministic differential equations allowing for cell reproduction and death, and cell ...
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Mathematical modeling of tumor therapy with oncolytic viruses: effects of parametric heterogeneity on cell dynamics
... an oncolytic virus is the current mainstream ...of oncolytic virus infection on tumors can range from no apparent effect, to reduction and stabilization of the tumor load ...with oncolytic ...
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Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials
... of oncolytic viruses as another tool in the cancer therapeutics ...These viruses do not simply lyse cells to achieve their cancer-killing effects, but also cause dramatic changes in the tumor immune ...
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Dynamics of a mathematical model for cancer therapy with oncolytic viruses
... Abstract. Actually, cancer is considered one of the leading causes of death in the world. Various therapeutic strategies have been developed to combat this dangerous disease. This article investigates a promising ...
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New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
... Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor ...of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease ...
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Immune cells: more than simple carriers for systemic delivery of oncolytic viruses
... Abstract: Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat ...of ...
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Oncolytic viruses as immunotherapy: progress and remaining challenges
... Abstract: Oncolytic viruses (OVs) comprise an emerging cancer therapeutic modality whose activity involves both direct tumor cell lysis and the induction of immunogenic cell death ...
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The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses
... Abstract: Oncolytic viruses (OVs) are an emergent and unique therapy for cancer patients. Similar to chemo- and radiation therapy, OV can lyse (kill) cancer cell directly. In general, the advantages of OVs ...
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Combination Vascular Delivery of Herpes Simplex Oncolytic Viruses and Amplicon Mediated Cytokine Gene Transfer Is Effective Therapy for Experimental Liver Cancer
... competent oncolytic viruses that selectively infect and lyse tumor cells ...as oncolytic agents along with replication- incompetent HSV amplicons as gene transfer vehi- ...
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Potential of oncolytic viruses in the treatment of multiple myeloma
... of oncolytic viruses as a novel treatment option for ...these viruses has demonstrated that their infection can be highly specific for MM cells and results in impressive therapeutic efficacy in a ...
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Cell carriers for oncolytic viruses: current challenges and future directions
... of oncolytic viruses to ...several oncolytic virus platforms using a wide range of car- rier cell types (Table ...of oncolytic viruses, one must consider the susceptibility of the cell ...
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Perspectives on immunotherapy via oncolytic viruses
... Oncolytic viruses (OVs) are defined as viruses able to selectively replicate in and kill cancer cells ...manipulate viruses, hin- dered research in this ...
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Prospects for combined use of oncolytic viruses and CAR T-cells
... Oncolytic viruses may also induce direct or indirect effects on the tumour microvasculature such as enhanced vascular permeability that are expected to be synergistic with CAR T-cell ...effect. ...
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Oncolytic Viruses for the Treatment of Cancer (A review)
... some oncolytic viruses at a viral multiplicity of infection (MOI) of ...of oncolytic virus to number of ...and oncolytic virus development requires the fulfillment of the same principles of ...
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The ex vivo purge of cancer cells using oncolytic viruses: recent advances and clinical implications
... Better purging methods are required to reduce the tumor contamination of the graft in order to improve the outcome associated with autologous HSCT. Similarly, outcomes of allogeneic HSCT may be improved by selectively ...
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Oncolytic viruses: overcoming translational challenges
... the viruses through the fenestrated capillaries of the lung, spleen, and liver; and nonspecific ...an oncolytic VV revealed that those receiving the highest dose (10 9 PFUs) showed low amounts ...
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Oncoselectivity in Oncolytic Viruses against Colorectal Cancer
... native oncolytic capacity [64]. This native oncolytic ability makes them potentially very useful as RCOVs, but in the case of the VSIV that potential is undercut by a very broad host tropism ...
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Targeting Human Glioblastoma Cells: Comparison of Nine Viruses with Oncolytic Potential
... replication-competent viruses merits ...harnessing oncolytic viruses include the use of conditional promoters upon which viral replication is depen- dent, mutation of viral genes such as the M ...
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Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/E BRAF mutant melanoma depends on JNK and TNF-α signaling
... Oncolytic viruses have the remarkable biological property of being able to replicate selectively in cancer cells, thus mediating tumor-selective ...combining oncolytic virotherapy with ionizing ...
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