Oncostatin M
STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
... Fig. 3. Effects of OSM, ERK inhibitor (U0126), and ERK siRNA on the protein expression of MMP-2 and MMP-9. Cells were pretreated with the ERK inhibi- tor U0126 (10 and 25 μM) for 1 h before treatment with or without OSM ...
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Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo controlled trials
... damage. Oncostatin M (OSM) is a member of the interleukin (IL)-6 family of secreted cytokines and is present in the inflamed synovium and blood of patients with RA ...
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Oncostatin M is a proinflammatory mediator In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules
... of oncostatin M have not yet been ...of oncostatin M under the control of nonspecific promoters is lethal (16), but expression using cell-specific promoters in lymphocytes of the early T cell ...
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Human rheumatoid arthritis tissue production of IL 17A drives matrix and cartilage degradation: synergy with tumour necrosis factor α, Oncostatin M and response to biologic therapies
... Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies Ell[r] ...
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Original Article The polymorphisms of oncostatin M receptor gene associated with increased risk of lung cancer
... Abstract: Oncostatin M receptor (OSMR) played an important role in tumorigenesis by inhibiting proliferation of tu- mor cells. But the relationship between OSMR polymorphism and lung cancer has not been ...
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Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity
... OSM, oncostatin M; OSMR, oncos- tatin M receptor; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PGE2, prostaglandin E2; PI, propidium iodide; PI3K, phosphatidylinositol 3-kinase; ...
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Detection of receptors for interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells
... (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF), all involve the signal transducer gp130: IL-6 and IL-11 induce homodimerization of gp130, while the rest heterodimerize gp130 with other ...
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A comparative study on oncostatin M secretion by transplantable melanoma cells with regard to their biological properties and progression
... 1. Bomirski A (1977) Biological properties of transplanta- ble melanomas in the Syrian hamster during 16 years maintenance by serial passages. Acta Med Ged, Gdańsk. 2. Bomirski A, Kozłowska K, Żurawska-Czupa B (1975) An ...
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Oncostatin M Promotes Breast Cancer Metastasis: Increased Expression of Pro-Angiogenic Factors, Inflammatory Cytokine Expression, and Circulating Tumor Cell Numbers
... Breast cancer is the most diagnosed cancer type in women and its resultant mortality is second only to lung cancer worldwide. While breast cancer is known to have many risk factors, inflammation remains an unquantifiable ...
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Oncostatin M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation
... Oncostatin M(OSM) is a member of the interleu- kin (IL)-6 family of cytokines, which includes IL-6, leukemia inhibitory factor (LIF), ciliary neurotrophic factor, cardiotrophin-1, IL-31, and ...
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Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells
... Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against ...
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Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings
... Oncostatin M (OSM) is linked with multiple biological responses including growth and differentiation. Previous reports showed inhibitory effects of OSM in tumor progression while others showed promoting ...
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Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
... cytokine oncostatin M has been shown to have proinflammatory ...cytometry. Oncostatin M expression was measured in the tissue sections by ...
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Original Article Effects of Oncostatin M on the neurological function of rats with spinal cord injury through STAT3 signal pathway
... Abstract: Objective: To investigate the effects and mechanisms of Oncostatin M (OSM) on spinal cord ischemia and reperfusion injury in rat model. Methods: Thirty healthy male Sprague-Dawley (SD) rats were ...
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Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice
... that oncostatin M (OSM) is produced by osteoblasts and osteocytes in mouse bone and that it has distinct effects when acting through 2 different receptors, OSM receptor (OSMR) and leukemia inhibitory factor ...
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Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications
... 8. Oncostatin M is expressed at sites of NHO following SCI in ...(A) Oncostatin M (Osm) mRNA expression is significantly increased in injured muscle after spinal cord injury ...
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Oncostatin M Contributes To Breast Tumor Metastasis
... receptor-positive (ER+) breast cancer cells are less aggressive and do not migrate until undergoing an epithelial-mesenchymal transition (EMT) induced by growth factors or cytokines. These studies examine the effect of ...
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OSTEOBLAST ONCOSTATIN M SIGNALING IN MODELED SPACEFLIGHT
... The bone remodeling cycle parallels wound healing, most obviously in the case of a gross fracture, but also on the microscale 45 . Like in wound healing, inflammatory cytokines are important signals in bone remodeling. ...
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Localization of Oncostatin-M Expression in Apical Periodontitis Lesions using Immunohistochemical Analysis
... that oncostatin M (OSM), a member of the interleukin-6 family, possesses cytostatic and pro-apoptotic effects in association with complex and poorly understood activities on osteoblast ...
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The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
... that oncostatin M (OSM) treatment induces HIF-1 α expression in hepato- cytes under normoxia, we first investigated whether the OSM-mediated upregulation of HIF-1α is a general effect for hepatocytes and ...
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