One-carbon metabolism
Concept mapping One-Carbon Metabolism to model future ontologies for nutrient–gene–phenotype interactions
... Presented here is a model for a novel form of data integration and visualization of nutrient–gene–phenotype relationships. The model highlights physiological and metabolic consequences, as well as potential alterations ...
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Polymorphism in one-carbon metabolism pathway affects survival of gastric cancer patients: Large and comprehensive study
... of one-carbon metabolism associated genes contribute to carcinogenesis via affecting DNA methylation, synthesis and repair ...[6]. One-carbon metabolism (OCM) pathway is a ...
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Prognosis of breast cancer is associated with one-carbon metabolism related nutrients among Korean women
... of one-carbon metabolism related nutrients intake and hormone specific breast cancer have been ...is one of the one-carbon metabolism related nutrients studies, was ...
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MTHFR C677T and postmenopausal breast cancer risk by intakes of one carbon metabolism nutrients: a nested case control study
... Cancer cohort [19]. Suzuki reported a significant 83% increased breast cancer risk among postmenopausal Japa- nese women with the TT genotype compared to wild-type [18]. Among 10 studies reporting estimates for ...
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One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond
... targeting one- carbon metabolism in both CSF and plasma, and to better understand its role in cognitive impairment and AD ...several one-carbon metabolites beyond Hcy as- sociated with ...
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Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One Carbon Metabolism Genes
... One-carbon metabolism (OCM) comprises a set of reactions involving folate coenzymes and is critical for essential processes including DNA methylation, cell proliferation, and the synthesis of nucleic ...
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Maternal one-carbon metabolism and infant DNA methylation between contrasting seasonal environments: A case study from The Gambia
... (29). One-carbon metabolism refers to the interlinking reactions of the folate, choline, methionine, ho- mocysteine, transsulfuration and transmethylation metabolic pathways (30, ...is one of ...
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In utero exposure to cigarette chemicals induces sex specific disruption of one carbon metabolism and DNA methylation in the human fetal liver
... The imprinted gene IGF2 has a major role in mediat- ing fetal growth [41] and altered DNA methylation at the IGF2 DMRs is known to be associated with human syndromic growth disorders, including Silver Russell and ...
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Maternal one-carbon metabolism and infant DNA methylation between contrasting seasonal environments: A case study from The Gambia
... interpretation can be difficult. However, our findings suggested the strongest loadings of each PC mapped onto different metabolic pathways. The major loadings for PC1 are involved in the folate metabolism cycle. ...
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Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism
... Only one study conducted among pregnant women has investigated the associations between MTR polymor- phism and SAM and SAH levels and reports no statistically significant association (Barbosa et ...
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Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia
... A number of studies have reported OCM alteration in SZ [1–4]. In the OCM cycle, methionine is synthe- sized by a chemical reaction between Hcy and a carbon atom provided by l-serine. Elevated peripheral l-serine ...
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The Many Flavors of Hyperhomocyst(e)inemia: Insights from Transgenic and Inhibitor Based Mouse Models of Disrupted One Carbon Metabolism
... Cobalamin-dependent methionine synthase catalyzes the next step in the regeneration of the methyl group of methionine (Fig. 3). In the course of this overall reaction, the methyl group of methyltetrahydrofolate is ...
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Index Catalog // Carolina Digital Repository
... Aberrant DNA methylation patterns are often associated with cancer; perhaps the genes whose expression is most prone to being affected by these changes are imprinted genes (for a review, see Falls 1999). Because of their ...
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PubMedCentral-PMC5180459.pdf
... regulating one-carbon metabolism with both arsenic metabolism and metabolic- related outcomes (13 – ...arsenic metabolism is well established ...The one-carbon ...
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Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism
... have one of the highest frequencies of the MTHFR 677T allele worldwide, above to that reported in some European and African populations (Wilcken et ...folate-mediated one-carbon metabolism ...
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Of Mouse And Methyl: An Investigation Of Methyl Donors, Methylation And Methyltransferases In The Pfc
... deficiency-related developmental disorders, autism and schizophrenia (Desai et al., 2016; Frye et al., 2016; Ramaekers et al., 2014). Exposure to FRα autoantibodies during gestation have been associated with increased ...
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CceR and AkgR Regulate Central Carbon and Energy Metabolism in Alphaproteobacteria
... Combinatorial regulation of central carbon and energy me- tabolism in alphaproteobacteria by a set of previously unchar- FIG 8 Conservation of CceR regulon across alphaproteobacteria. Predicted conservation of the ...
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Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes
... Again, PEGylated CNTs exhibit very good bio- compatibility. Schipper et al. reported that PEG-SWCNTs and PEG-PL/SWCNTs were nontoxic and biocompatible [22]. Although both SWCNTs re- tained in liver for more than 4 ...
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Regulatory Tasks of the Phosphoenolpyruvate Phosphotransferase System of Pseudomonas putida in Central Carbon Metabolism
... olized via the ED pathway to pyruvate, while the other ~4% of the sugar was channeled into the PP route (Fig. 3). Also as anticipated, no signs of glycolytic activity were detected, as P. putida lacks the ...
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Stoichiometric model of folate-dependent metabolism of one-carbon units in human placenta
... folate-dependent one- carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate ...
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