OPG/RANKL
Evaluating the effects of pine bark extract supplementation on bone turnover and the possible mechanisms of OPG/RANKL signaling in postmenopausal osteopenic women: a trial protocol
... Methods: This randomized double-blind clinical trial will be conducted on postmenopausal osteopenic women in Shariati Hospital of Tehran University of Medical Sciences, Tehran, Iran. A total of 44 postmenopausal women ...
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TNF Super Family Members OPG, RANKL, RANK and Osteoporosis: a link
... Receptor activator of nuclear factor kappa B (RANK), a member of the TNF receptor superfamily, is a type É transmembrane protein containing four cysteine-rich pseudorepeat domains in the extracellular region, a hallmark ...
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Osteoprotegerin, a new actor in vasculogenesis, stimulates endothelial colony-forming cells properties
... that OPG underlies a possible link between the osseous and vascular ...high OPG serum levels to the severity of cardiovascular diseases such as atherosclerosis and myocardial ischemia ...that OPG ...
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Association between low bone mass and the serum RANKL and OPG in patients with nephrolithiasis
... of OPG with BMD measurement, which high- lights the potential link between nephrolithiasis and reduced bone mass, but due to the cross-sectional na- ture of our study cautious the causal assumption be- tween them; ...
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Alpha-Calcitonin Gene-Related Peptide Can Reverse The Catabolic Influence Of UHMWPE Particles On RANKL Expression In Primary Human Osteoblasts
... in RANKL mRNA expres- sion and RANKL protein levels, as well as a decrease of AP ...High RANKL levels and low OPG le- vels lead to a stimulation of osteoclasts via the ...
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Original Article Effect of hypoxia on the expression of RANKL/OPG in human periodontal ligament cells in vitro
... (OPG). OPG is the soluble decoy receptor of ...between RANKL and RANK and further block their effects on osteoclastogenesis and bone resorp- ...Local OPG gene transfer to periodontal tis- sue ...
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Effect of low-level laser therapy on bisphosphonate-treated osteoblasts
... [15]. RANKL, OPG, and M-CSF are essential factors that are produced by the osteoblast/stromal cells for osteoclast-osteoblast in- ...teractions. RANKL is an important factor in protecting bone ...
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Serum levels of osteoprotegerin and receptor activator of nuclear factor -κB ligand in children with early juvenile idiopathic arthritis: a 2-year prospective controlled study
... of RANKL, a lower OPG/RANKL ratio, and comparable OPG levels compared to controls ...serum OPG levels and a higher OPG/ RANKL ratio in oligoarticular and polyarticular JIA ...
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Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL
... by RANKL, a cytokine member of the tumor necrosis factor (TNF) superfamily (TNFSF11) that binds to its receptor RANK at the surface of osteoclasts ...[14]. OPG (TNFRSF11B) is a soluble protein that acts as ...
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Original Article Berberine suppresses osteoclastogenesis and osteolysis in a mouse model
... The OPG/RANKL/RANK pathway has been found to play an important role in osteoclast biology in recent years, and the biological effects of wear particles induce imbalances in RANKL/OPG, ...
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Original Article The role of TNF-α and IFN-γ in the formation of osteoclasts and bone absorption in bone tuberculosis
... pathways. OPG is mainly secreted by osteo- blast and lymphocytes, and is one indispens- able molecule during the differentiation and activating regulation of ...osteoclast. OPG is one soluble receptor of ...
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Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma
... for OPG, RANKL and aSMA was performed as previously described (Khurram et al, 2010) using the avidin-biotin peroxidase complex (ABC) method (ethical approval ...
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Changes in RANKL during the first two years after cART initiation in HIV infected cART naïve adults
... soluble RANKL important for the accelerated bone loss may have taken place already before week 12, since it is well established that bone turnover, measured as increasing levels of C-terminal- ...
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The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis: The TRIO study
... TNFRII+. RANKL and OPG were measured to evaluate potential mediation of the bisphosphonate ...on RANKL and OPG throughout the study ...
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Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis
... Patients with COPD have evidence of systemic inflam- mation, which may be responsible for some comorbid- ities. Levels of inflammatory cytokines such as IL-1 b , IL- 6 and TNF- a are increased in the systemic circulation ...
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Vertebral fractures in patients with inflammatory bowel disease COMPARED with a healthy population: a prospective case-control study
... ng/ml). OPG and RANKL levels, although slightly higher in osteoporotic patients with IBD, were not related to bone mass, showing similar values in patients with osteopenia, osteoporosis, and normal bone ...
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Total glucosides of paeony prevents juxta articular bone loss in experimental arthritis
... Interleukin-17 (IL-17) plays a vital role in RANKL in- duction, osteoclastogenesis and bone erosion. IL-17 is produced mainly by pro-inflammatory T-helper subset (Th17) cells and both IL-17 and Th17 cells are ...
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TGF-β and Physiological Root Resorption of Deciduous Teeth
... TGF-β3, RANKL, RANK, TRAP/ACP5, calcitonin receptor (CALCR) and nuclear factor of activated T-cells 1 (NFATc1) representing odontoclast promotion and OPG representing odontoclast suppression (Figure ...
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Interpretation of Non-Genetic Oral and Maxillofacial Osteogenic Conditions in the Basis of New Findings in the Field of Osteoblastogenesis and Osteoclastogenesis
... The ratio of nuclear factor kB ligand (RANKL) to osteoprotegerin (OPG) is not the only tool to explore the interaction between osteoblasts and osteoclasts. Sphingosine 1-phosphate (S1P) and Sclerostin work ...
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Original Article Effect of TNF-α on osteoporosis by regulating the RANKL/OPG signaling pathway
... declined, RANKL protein enhanced, and OPG protein was attenuated in the OP group compared with sham group (P < ...attenuated RANKL protein expression, and enhanced OPG protein expression ...
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