Oral insulin
Nanolayer encapsulation of insulin- chitosan complexes improves efficiency of oral insulin delivery
... Current oral insulin formulations reported in the literature are often associated with an unpredictable burst release of insulin in the intestine, which may increase the risk for problematic ...of ...
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ORAL INSULIN: AN OVERVIEW
... an insulin preparation that is placed under the tongue or in between the cheek and gum, and is slowly ...an insulin spray (Oralin®) which can be delivered via the company's Rapid Mist ...subcutaneous ...
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COMPUTATIONAL DESIGN OF NOVEL ORAL INSULIN CONJUGATES FOR THE DEVELOPMENT OF SOLID ORAL INSULIN DOSAGE FORMS
... injection, oral insulin conjugates (OICs) has the potential to mimic the natural route of endogenous insulin secreted by the pancreas through the portal vein directly to the liver and then to the ...
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APPLICATION OF POLYMERIC NANOPARTICLE FOR ORAL DELIVERY OF INSULIN
... for insulin. Oral delivery is perhaps the most enticing alternative to parenteral delivery due to the general acceptance of orally administered ...However, oral delivery arguably represents the most ...
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A REVIEW ON NOVEL APPROACHES FOR ORAL DELIVERY OF INSULIN
... of insulin is done by insulin replacement therapy and current route of its administration is through subcutaneous injection having many ...with insulin injections novel approaches for insulin ...
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Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
... of oral insulin microspheres using chitosan (structure as shown in Figure S1) as carrier is ...loaded insulin showed sustained release, which could facilitate the investigation on the protective role ...
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DEVELOPMENT AND CHALLENGES FACING FOR INSULIN ORAL DELIVERY
... achieve oral insulin delivery using different ...that oral insulin drug delivery shows very poor absorption, less bioavailability, low stability and higher inter-patient ...
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OPTIMIZATION OF FORMULATION OF INSULIN MICROSPHERES FOR ORAL DELIVERY
... for oral insulin ...entrap insulin in microspheres, it is expected to protect insulin from degradation by gastric juice and allow it to be released in the region of the GIT of pH > 6 ...
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Insulin Inclusion into a Tragacanth Hydrogel: An Oral Delivery System for Insulin
... for oral insulin ...research, insulin particles were prepared by the inclusion of insulin into a tragacanth ...(SEM). Insulin–tragacanth interactions at varying pH ...that ...
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Nanotechnology based Oral Delivery of Insulin – A Retrospect
... effective oral insulin therapy to treat ...solid oral dosage form of insulin using different types of polymers in Nanotechnology ...Mellitus oral delivery is still a exciting job in ...
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Luteolin in the Management of Type 2 Diabetes Mellitus
... modifications, oral hypoglycaemic agents, insulin secretagogues, insulin sensitizers and ...these oral hyperglycemia drugs lose their efficacy in due course of ...
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2288.pdf
... Goudswaard AN, Stolk RP, ZuithoffP, deValk HW, Rutten GE. Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diab[r] ...
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Negative association of acetate with visceral adipose tissue and insulin levels
... Other limitations of this study include the small sample size and a relatively homogenous population, as all the subjects were obese women. Moreover, variables that alter acetate levels such as age, alcohol intake, and ...
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Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test
... TITLE: Effect of varying the dose of corn syrup on the insulin and glucose response to the oral sugar test... Title: Effect of varying the dose of corn syrup on the insulin and glucose[r] ...
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Concomitant therapy with pioglitazone and insulin for the treatment of type 2 diabetes
... analogue insulin is chosen for insulin treatment, management of postpran- dial hyperglycemia may be ...and insulin is beneficial to prevent glucose excursions and/or ...to insulin is also ...
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Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study
... It has been previously shown that hyperglycemia re- duces survival and impairs the function of EPCs in vitro [30] and that in patients with type 2 diabetes mellitus the levels of circulating EPCs are closely related to ...
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High fat diet-induced inflammation and oxidative stress are attenuated by N-acetylneuraminic acid in rats
... We demonstrated for the first time that dietary Neu5Ac supplementation attenuated HFD-induced weight gain, dyslipidemia, insulin resistance, inflammation and oxidative stress, partly through the transcriptional ...
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Phase 2 study evaluating intermittent and continuous linsitinib and weekly paclitaxel in patients with recurrent platinum resistant ovarian epithelial cancer.
... Linsitinib (OSI-906) is an orally active, dual IGF1R and insulin recep- tor (IR) inhibitor, with anti-proliferative effects in tumor cell lines and in vivo xenograft tumor models [18,19]. By inhibiting both IGF1R ...
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Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin
... free insulin 1 IU/kg was adminis- tered subcutaneously in the first ...free insulin 20 IU/kg, and saline were administered orally to the second group, the third group, and the fourth group, ...to ...
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Inhaled human insulin (Exubera<sup>®</sup>): clinical profile and patient considerations
... with oral antidiabetic agents can be effective at achieving glycemic control in type 2 diabetes, but as a chronic disease marked by a progressive course, most patients eventually require insulin therapy for ...
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