orphan receptor
Tie1: an orphan receptor provides context for angiopoietin 2/Tie2 signaling
... the orphan receptor Tie1, which has been implicated as both a positive and negative regulator of ANG1/Tie2 signaling, and ANG2, which can serve as both a Tie2 agonist and antagonist, depending on the ...
5
Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88
... the orphan receptor ...GPR88 receptor agonists, in theory, this calcium mobilization assay can be used to identify other ligands as well, including competitive and noncompeti- tive antagonists, ...
9
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
... we could not detect receptor protein. This raises the fascinating possibility that GPR37L1 is a previously undiscovered component of the CNS-cardiovascular axis. Widely expressed in astrocytes throughout the ...
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Orphan nuclear hormone receptor NR4A1 interacts with HPV16 E2 regulatory protein
... The orphan nuclear hormone receptors are believed to be able to interact with DNA in the absence of any ...This orphan receptor can bind DNA as a monomer to an estrogen receptor half-site ...
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The role of novel IL 1 family members in Inflammatory Bowel Disease
... This demonstrates that lL-36 signaling in vivo is regulated by the orphan receptor SIGIRR and may suggest that enhanced responsiveness to IL-36 signaling may play a role in the increased[r] ...
176
An orphan viral TNF receptor superfamily member identified in lymphocystis disease virus
... genotypes. As virus-host interactions are probably highly species dependent, the lack of binding partners for LDVICp016 under the tested conditions may reflect a strict species dependence of the sought interaction pair. ...
6
Identification and characterization of Ror2 as a tumor cancer cell specific kinase in renal cell carcinoma
... Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma.. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarc[r] ...
191
Human resistin and the RELM of Inflammation in diabesity
... Resistin-like molecule; ROR1: Receptor tyrosine kinase-like orphan receptor 1; SH3: Src Homology 3; SNP: Single nucleotide polymorphism; T2DM: Type 2 Diabetes mellitus; TGF: Transforming[r] ...
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Microcantilever based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor Ligand Interactions
... X receptor (PXR) is of vital importance in pharmaceutical and exogenous compound metabolism within the ...this orphan receptor’s activation by various pharma- ceuticals, xenobiotics, and endocrine ...
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Key regulator of cellular metabolism, estrogen-related receptor α, a new therapeutic target in endocrine-related gynecological tumor
... nuclear orphan receptor (OR) has been the focus of increasing interest and was named an OR because of its unique physiological effect and the inability to identify correspond- ing specific natural ...
9
Expression of ROR1 Gene in Patients with Acute Lymphoblastic Leukemia
... 18. Shabani M, Asgarian Omran H, Farsangi MH, Vossough P, Sharifian RA, Toughe GR, et al. Comparative expression profile of orphan receptor tyrosine kinase ROR1 in Iranian patients with lymphoid and myeloid ...
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Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management
... Although most GPCRs can activate more than a single G α subtype, they show a preference for one subtype over another. GPCR function is tightly regulated, and they become desensitized after prolonged exposure to its ...
9
6027.pdf
... soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) and tartrate- resistant acid phosphatase 5b (TRAP5b) along with decrease in serum osteoprotegerin (OPG) levels (Yan et ...
129
Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin
... The orphan nuclear receptor 4A2 (NR4A2/NURR1, nuclear receptor related-1) has recently emerged as a novel transcription factor with regulatory roles in in- flammatory arthritis ...nuclear ...
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Coronary disease is not associated with robust alterations in inflammatory gene expression in human epicardial fat
... Quantitative reverse transcription PCR and immunohistochemistry show that there is no difference in inflamma- tion between EAT of cases and controls. We performed quantitative reverse transcription (qRT-PCR) to verify ...
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The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon
... The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon The Pseudomonas aeruginosa Orphan Quorum Sens[.] ...
10
Orphanhood, informal orphan caregiving and the impact of community-based organizations in the context of HIV/AIDS, in Nyanza, Kenya.
... informal orphan caregivers ...informal orphan caregivers say in this study is contradictory and I can only offer possibilities as to the reasons why this ...informal orphan caregivers, the in-depth ...
141
Identification of Novel Transcription Start Sites and Distinct Proximal Promoter Regions for Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2
... The use of in vivo models to study CYP induction are very valuable, but sometimes in animal models, such as rodents, species specific differences do not allow for accurate assessment of the potential for a compound to ...
115
Incentives for orphan drug research and development in the United States
... for orphan drugs being evaluated for their therapeutic ...FDA-designated orphan drug indications ...the orphan market exclusivity period, the FDA cannot approve a NDA (new drug application) or a ...
7
Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita
... hormone receptor superfamily (12, 14, 15). DAX-1 is classi- fied as an orphan nuclear receptor because no specific ligand has been identified to date ...
8