osteoclast precursors
Interleukin 17A upregulates receptor activator of NF κB on osteoclast precursors
... Forty osteoclast-related genes were evalu- ated by quantitative PCR to uncover the mechanism by which IL-17A synergizes with RANKL to induce osteo- ...of osteoclast precursors showing increased ...
11
The proliferative human monocyte subpopulation contains osteoclast precursors
... donors, osteoclast precursors reside predominantly in the PM population and could be detected even after proliferation in ...certain osteoclast markers (CTR, Cath K, and RANK) and an ability to ...
6
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function
... Erosive arthritis, generalized bone loss, and increased BM OCPs in SKG arthritis. (A–C) μCT analysis of female SKG mice with chronic arthritis (SKG-A) compared with healthy littermate controls (SKG-c) shows erosions and ...
15
Immortalization of osteoclast precursors by targeting Bcl XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice
... OCL precursors from these transgenic mice to apoptosis demonstrated that the increased numbers of OCL precursors in marrow from bcl-XL/Tag mice was due to their increased survival rather than ...
11
CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis
... OC precursors in HC and PsA patients, ...by osteoclast (OC) count after eight-day culture in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating ...
14
Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures
... AXII significantly increased OCL-like multinucleated cell formation. Time-course studies suggested that AXII acted on the proliferative stage of OCL precursors and that AXII increased thymidine incor- poration in ...
10
Water extract of the fruits of Alpinia oxyphylla inhibits osteoclast differentiation and bone loss
... in osteoclast differentiation ...in osteoclast-poor osteope- trosis, and NFATc1-deficient osteoclast precursors fails to differentiate into osteoclasts in vitro ...of osteoclast ...
9
Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
... increased osteoclast number and bone resorption in the clinic [53, 54] and mice with an osteoblast-specific deletion of Stat3 have an osteope- nic phenotype ...and osteoclast precursor cells to downregulate ...
16
Stauntonia hexaphylla (Lardizabalaceae) leaf methanol extract inhibits osteoclastogenesis and bone resorption activity via proteasome mediated degradation of c Fos protein and suppression of NFATc1 expression
... origin. Osteoclast differentiation is critically regulated by macrophage colony-stimulating factor (M-CSF) and re- ceptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL) [1, 8, ...of osteoclast ...
9
Bisphosphonates: mechanisms of action
... in osteoclast number can occur either through direct action on osteoclast precursors, or indirectly by stimulating the osteoblasts to produce an in- hibitor of osteoclast ...formation. ...
6
Therapeutic intervention of inflammatory/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway
... destruction Osteoclast precursors selectively express CX3CR1, whereas FKN is expressed on ...containing osteoclast precursors, whereas immobilized FKN mediates the firm adhesion of ...
5
Physiopathology of osteoclast in bone
... common precursors of osteoclasts and ...in osteoclast precursors, rendering them more responsive to RANKL ...in osteoclast formation and hence osteopetrotic ...
104
Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes
... in osteoclast precursors and augments the stimulatory effects of RANKL on osteoclast differentiation [28,29] thereby inducing bone resorption in vitro [30] and in vivo ...from osteoclast ...
9
6129.pdf
... the osteoclast lineage and acts as both an activating and survival factor for mature ...on osteoclast precursors and signals the survival and proliferation of the ...occur, osteoclast ...
65
Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
... [12]. Osteoclast differentiation is coordinated by the binding of macrophage colo- ny-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) to their respective recep- tors c-Fms and RANK on the ...
11
The molecular basis of osteoclast adhesion
... that osteoclast m aturation involves an interm ediate cell w ith features com m on to both osteoclasts and m ...the osteoclast precursors are derived from CFU- ...d osteoclast m arkers, to ...
348
Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling
... To investigate the effect of fangchinoline treatment (Figure 1A) on osteoclast formation, BMM cells were incubated with different concentrations of fangchinoline (0.125, 0.25, 0.5, 1 μM) and RANKL (50 ng/ml) for 5 ...
11
Effect of Bisphosphonate on Osteoclast of Bone
... excessive osteoclast-mediated bone resorption, such as hypercalcemia of ma- lignancy, local osteolytic hyperclacemia, Paget’s disease and postmenopausal osteoporosis [14] ...
7
Noncanonical G Protein Dependent Modulation of Osteoclast Differentiation and Bone Resorption Mediated by Pasteurella multocida Toxin
... Signaling cascades induced by PMT. Next we compared the effect of PMT with that of RANKL, which acts via RANK to induce the MAP kinase pathway and to activate gene transcription, re- sulting in differentiation of ...
9
Signaling crosstalk between RANKL and interferons in osteoclast differentiation
... It has recently been found that activated T cells promote osteoclastogenesis through expression of RANKL and regulate bone loss in autoimmune arthritis [18]. The results presented above revealed that activated T cells ...
6