p-AKT
Expression and significance of CD44 and p AKT in pancreatic head cancer
... phosphorylated AKT (p-AKT) [5]. p-AKT phosphorylates multiple proteins implicated in cellular processes leading to induction of cell survival and inhibition of ...
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Original Article microRNA-218 promotes sensitivity of human pancreatic cancer cells to gemcitabine through HMGB1 and the PI3K/Akt pathway
... GEM was purchased from Eli Lilly and Company (USA and Canada). Quercetin was purchased from Sigma-Aldrich (San Diego, CA, USA). Wortmannin, an inhibitor of the phosphoinosit- ide 3-kinase (PI3K) pathway, was purchased ...
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Overexpression of <em>PI3K p110α</em> contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
... with p-MET, p-ERK1/2, p-AKT, p-S6, and PI3K p110 α , β , γ rabbit monoclonal antibodies and subsequently with goat anti-rabbit (horseradish peroxidase [HRP]) antibodies, and detected by ...
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Original Article Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer
... TGF-α, P-AKT and PTEN in the genesis of non-small cell lung cancer ...and P-AKT by the use of specific antibody through immunohistochemistry as directed by the manufacturer, and detected PTEN ...
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Phosphorylation and inactivation of PTEN at residues Ser380/ Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway
... anti- Akt (ab8805; 1:400), anti-p-Akt (Ser473) (ab66138; 1:400), anti-p-Akt (Thr308) (ab38449; 1:200), anti-Bad (ab32445; 1:1000), and anti-p-Bad (Ser136) (ab28824; 1:1000) ...
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Original Article Oxymatrine attenuates lipid accumulation in HepG2 cells by inducing autophagy
... SCD1, p-Akt/Akt, and mTOR were increased in the fructose ...SCD1, p-Akt/Akt, and mTOR were decreased, and the expression levels of LC3B, Beclin-1, and Atg7 were significantly ...
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Toxicity Induced by Madopar (l-DOPA) during Curing Parkinson’s Disease by Inhibiting Mitochondrial Function and AKT Pathway
... of AKT, the target path- way of insulin, and the activity targets of phosphor- ylation are 473 and 308, ...respectively. Akt also known as PKB, plays an important role in cell survival and apoptosis 14 ...
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The different radiosensitivity when combining erlotinib with radiation at different administration schedules might be related to activity variations in c-MET-PI3K-AKT signal transduction
... C-MET, p-C-MET, AKT, and p-AKT increased in all of the ...and AKT levels were correlated with those of p-C-MET and p-AKT (Figure ...and p-C-MET was ...
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The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... Moreover, at the beginning of anesthesia, the general anesthesia drugs widely distributed in the neural sites of brain, which may inhibit the brain functions of conscious, nervous motion, learning and memory and so on, ...
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<p>Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas</p>
... MAPK, AKT is another signaling pathway that plays a critical role in the progression of uterine leio- ...And p-AKT expression was signi fi cantly increased in uterine leiomyomas, and the cell ...
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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways
... of p-ERK, p-AKT, mTOR, p-mTOR, and p-P70S6K, and reduced expression of p-P38 and LC3-II (the marker of autophagy) in 231/Gem as compared to control ...and p-AMPK can be ...
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COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization
... proteins were degraded more rapidly in shCOL11A1 cells than in shcontrol cells (Fig. 5D). The results of a cycloheximide pulse-chase experiment indicated that the half-life of PDK1 protein was significantly lower in ...
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Original Article Evaluation of AKT phosphorylation and PTEN loss and their correlation with the resistance of rituximab in DLBCL
... [27]. AKT, a serine/threonine protein kinase, can regulate various down- stream reactions of PI3K in PI3K/AKT ...containing AKT, activation of AKT, and point mutations of PIK3CA [28, ...of ...
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Mitomycin C treatment induces resistance and enhanced migration via phosphorylated Akt in aggressive lung cancer cells
... the p-Akt plays a key factor in the chemotherapeutic agent-induced resistance in NSCLC ...Indeed, p-Akt activation is involved in the process of apoptosis inhibition in a variety of human ...
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PBX3 is associated with proliferation and poor prognosis in patients with cervical cancer
... Notes: (A) Western blotting analysis of PBX3, total aKT (t-aKT), and phosphorylated aKT (p-aKT), in hela and siha cells transfected with empty shrnavector and with PBX3silenced. gaPDh ...
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<p>NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling</p>
... Total protein from transfected cells was obtained using Whole Cell Lysis Assay (Keygen Biotech, China). Protein samples were subjected to SDS – PAGE and trans- ferred to PVDF membranes (Millipore, USA). After blocking ...
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Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... of Akt, is involved in the cell proliferation and apopto- sis induced by multiple growth factors and cyto- kines [40], and NF-κB expression has been found to promote cell growth and play a critical role in ...
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The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
... higher p-mTOR-positive rate than females (66% vs 27%, P = ...32%, P = 0.063) and p-AKT-positive rate (68% vs 37%, P = ...41%, P = 0.023) and lower p-mTOR-positive ...
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Original Article EBV-LMP1 regulating AKT/mTOR signaling pathway and WWOX in nasopharyngeal carcinoma
... and AKT/mTOR signaling pathway showed when CNE1-LMP1 was compared with CNE1 by the key protein of AKT, p-AKT, p70S6K and p-p70S6K, P values were ...of p-AKT, ...
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Original Article The protective effect of cardamonin on the factors involved in delayed cerebral vasospasm in a rat model of subarachnoid hemorrhage
... of p-AKT was ...of p-AKT (ser473) was significantly higher in the SAH rats (P < ...while p-AKT (ser473) in the SAH + cardamonin group was significant- ly lower compared ...
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